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Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

A new study published on the medRxiv* preprint server analyzed the trajectories of anti-SARS-CoV-2 antibodies in patients from the RituxiVac study were compared to healthy volunteers. In addition, they investigated the immunogenicity of a third vaccine dose in previously non-responding patients.

23 Nov 2021

CDC study finds Pfizer-BioNTech COVID vaccine provides high protection against hospitalization in adolescents

New research from the Centers for Disease Control & Prevention (CDC) suggest vaccines are highly protective against severe acute respiratory coronavirus 2 (SARS-CoV-2). Two doses of the Pfizer-BioNTech vaccine showed a 93% effectiveness against hospitalization. The findings add to a previous clinical trial that found vaccinated adolescents with 100% protection against SARS-CoV-2 infections.

23 Nov 2021

Higher antibody level correlates with greater vaccine protection against COVID-19

By measuring antibodies against the SARS-CoV-2 spike protein in participants in a phase 3 trial of the Moderna COVID-19 vaccine, researchers found that the higher the antibody level, the greater the vaccine protection against COVID-19.

23 Nov 2021

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A new study, published on the bioRxiv* preprint server, has discovered a class of new immunostimulatory RNAs while studying influenza infection-associated host genes in human lung epithelial cells using small interfering RNAs (siRNAs). Scientists revealed that these short duplex RNAs could induce type I and type III interferons (IFN-I/III) in a wide variety of cells.

23 Nov 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

Mouthwash containing an antiviral phthalocyanine derivative shortens hospitalizations due to COVID-19

In a study published in the journal Scientific Reports, a research group from Brazil showed how antiviral anionic phthalocyanine derivative used in a mouthwash protocol may not only reduce the symptoms of coronavirus disease (COVID-19), but also hamper the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

23 Nov 2021

Anti-inflammatory drug used to treat gout does not reduce the risk of COVID-19 mortality

Colchicine, a cheap anti-inflammatory drug normally used to treat gout, doesn't lessen COVID-19 severity or stave off the risk of death from the infection in hospital patients, finds a pooled analysis of the available evidence, published in the open access journal RMD Open.

23 Nov 2021

Disease/Infection News

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

CDC study finds Pfizer-BioNTech COVID vaccine provides high protection against hospitalization in adolescents

Higher antibody level correlates with greater vaccine protection against COVID-19

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

Mouthwash containing an antiviral phthalocyanine derivative shortens hospitalizations due to COVID-19

Anti-inflammatory drug used to treat gout does not reduce the risk of COVID-19 mortality

Time of starting antiretroviral therapy can influence tumor development In HIV patients

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

Study shows risk of MIS-C post mRNA vaccination against COVID-19 in children with autoimmune complications

Strong antibody responses against harmless coronaviruses may protect against SARS-CoV-2

SARS-CoV-2 moves between permissive cells and non-permissive neuronal cells via tunneling nanotubes (TNT)

Two-meter COVID-19 rule is not a concrete measurement of safety, say researchers

Study reveals extra burden of COVID-19 adverse events in end-stage kidney disease patients

Antigenic cocktail produced in Nicotiana benthamian plant as a potential COVID-19 vaccine candidate

Tobacco mosaic virus nanoparticle-based novel COVID-19 vaccine candidate

Inactivated virion-based vaccine confers robust cell-mediated immunity against major SARS-CoV-2 variants

Systematic review finds COVID-19 vaccine efficacy remains high for at least six months

An increase in the half-life of remdesivir for COVID-19 treatment

What does the future look like for bleeding disorders?

How agentic AI is reshaping laboratory workflows

Fourier 80: bringing benchtop NMR systems to the laboratory

How industrial hygiene flow calibration supports defensible exposure data

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