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Researchers develop saliva testing method for SARS-CoV-2 using robotic RNA extraction

Researchers have developed an automated method of RNA extraction from saliva samples to allow faster processing times and high test sensitivity. Saliva testing could be used as an alternative to swab testing for coronavirus disease 2019 (COVID-19) surveillance.

12 Jan 2021

Could Vitamin D be an effective adjuvant to help mitigate the COVID-19 pandemic?

As the coronavirus pandemic continues to wreak havoc across the globe, there is a dire need for effective and safe therapeutics and vaccines. Overall, the pandemic has infected more than 90.87 million people and taken more 1.94 million lives.

12 Jan 2021

Headache as COVID-19 symptom could indicate milder disease, study finds

Researchers at the Hospital Universitario de La Princes in Madrid, Spain, found that patients with COVID-19 who developed headaches as an early symptom of infection had a milder illness and less risk of death.

12 Jan 2021

Study shows a 25% increase in food insufficiency during COVID-19 pandemic

A new study published in the American Journal of Preventive Medicine found a 25% increase in food insufficiency during the COVID-19 pandemic. Food insufficiency, the most extreme form of food insecurity, occurs when families do not have enough food to eat.

12 Jan 2021

ADC histogram analysis can predict tumor proliferation, survival in immunocompetent patients with PCNSL

The cover for issue 45 of Oncotarget features Figure 3, "Representative images of whole tumor volume segmentation of the co-registered T1 post-contrast sequence and apparent diffusion coefficient (ADC) map, yielding the corresponding ADC histogram distribution utilized for data analysis," recently published in "Diffusion-weighted MR imaging histogram analysis in HIV positive and negative patients with primary central nervous system lymphoma as a predictor of outcome and tumor proliferation" by Khan, et al.

12 Jan 2021

Wearable heart monitors and deep learning can provide early warning of SARS-CoV-2 infection

A recent study, appearing as a preprint on the medRxiv* server, reveals the possibility of early prediction of SARS-CoV-2 infection using data on the resting heart rate in the presymptomatic period.

12 Jan 2021

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

A shadow over the promising inhaled interferon beta COVID-19 therapy has been cleared with the discovery that although it appears to increase levels of ACE2 protein - coronavirus' key entry point into nose and lung cells - it predominantly increases levels of a short version of that protein, which the virus cannot bind to.

12 Jan 2021

Study shows COVID-19 pneumonia is different from typical pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung over the course of hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body's immune system within the first few days of the illness.

12 Jan 2021

Researchers study the behavior of regulatory T cells to understand periodontal disease

In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone?

12 Jan 2021

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Now, a new preprint research paper published on the bioRxiv server shows how closely the antibodies formed in exposed humans resemble the germline antibody molecules. This could lead to the development of novel therapeutics to counter the pandemic.

12 Jan 2021

Patient with hypertension or cardiovascular diseases experienced critical disease progression with COVID-19

COVID-19 patients who also suffer from high blood pressure are more likely to fall severely ill with the disease, which also leaves them at greater risk of death.

11 Jan 2021

COVID-19 taking a disproportionate toll on female healthcare workers

Women in the healthcare workforce seem to be suffering stress and burnout in the current pandemic situation, disproportionately when compared to men, suggests a new preprint research paper published on the medRxiv server.

11 Jan 2021

SARS-CoV-2 exposure in England could be double reported seroprevalence

A new study that recently appeared on the preprint server medRxiv* makes use of a combined method to estimate population exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), taking into account the fact that patients who recover from the infection often do not have circulating antibodies against the virus.

11 Jan 2021

The mystery of Giglio island’s resistance to COVID-19

An intriguing new study explores the mechanisms by which an Italian island called Giglio remained resistant to coronavirus disease 2019 (COVID-19) even after much exposure.

11 Jan 2021

Study supports continuing phase 3 trials of Ad26.COV2.S SARS-CoV-2 vaccine

An international team of researchers has provided further evidence to confirm the immunogenicity and efficacy of a recombinant adenovirus vaccine currently being tested in phase 3 trials for its ability to protect against infection with severe acute respiratory coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

11 Jan 2021

Extract of medicinal plant Artemisia annua interferes with replication of SARS-CoV-2 in vitro

Researchers in the United States have shown that extracts of an aromatic herb called Artemisia annua inhibit the replication of severe acute respiratory coronavirus (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

11 Jan 2021

Study aims to halt further isolation of people aging with HIV during COVID-19 pandemic

The School of Medicine at the University of California, Riverside, has received a grant aimed at halting further isolation of people aging with HIV during the COVID-19 pandemic.

11 Jan 2021

Antibody recognition of linear SARS-CoV-2 epitopes preserved in mutated B.1.1.7 strain

In a recent medRxiv research paper, the US scientists examined the effects of non-synonymous mutations in the circulating B.1.1.7 strain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on linear antibody epitope signal for viral spike glycoprotein and nucleoprotein – and demonstrated that mutations should not result in immune evasion.

11 Jan 2021

Infectious disease early warning system compensates for existing gaps in surveillance

Researchers at Columbia University Mailman School of Public Health developed an infectious disease early warning system that includes areas lacking health clinics participating in infectious disease surveillance.

11 Jan 2021

Study finds association between severity of COVID-19 and shorter telomeres

Patients with severe COVID-19 disease have significantly shorter telomeres, according to a study conducted by researchers at the Spanish National Cancer Research Centre in collaboration with the COVID-IFEMA Field Hospital, published in the journal Aging.

11 Jan 2021

Disease/Infection News

Researchers develop saliva testing method for SARS-CoV-2 using robotic RNA extraction

Could Vitamin D be an effective adjuvant to help mitigate the COVID-19 pandemic?

Headache as COVID-19 symptom could indicate milder disease, study finds

Study shows a 25% increase in food insufficiency during COVID-19 pandemic

ADC histogram analysis can predict tumor proliferation, survival in immunocompetent patients with PCNSL

Wearable heart monitors and deep learning can provide early warning of SARS-CoV-2 infection

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

Study shows COVID-19 pneumonia is different from typical pneumonia

Researchers study the behavior of regulatory T cells to understand periodontal disease

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Patient with hypertension or cardiovascular diseases experienced critical disease progression with COVID-19

COVID-19 taking a disproportionate toll on female healthcare workers

SARS-CoV-2 exposure in England could be double reported seroprevalence

The mystery of Giglio island’s resistance to COVID-19

Study supports continuing phase 3 trials of Ad26.COV2.S SARS-CoV-2 vaccine

Extract of medicinal plant Artemisia annua interferes with replication of SARS-CoV-2 in vitro

Study aims to halt further isolation of people aging with HIV during COVID-19 pandemic

Antibody recognition of linear SARS-CoV-2 epitopes preserved in mutated B.1.1.7 strain

Infectious disease early warning system compensates for existing gaps in surveillance

Study finds association between severity of COVID-19 and shorter telomeres

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich

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