Disease/Infection News

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FAU researchers develop simplified, rapid SARS-CoV-2 detection protocol

To properly monitor and help curb the spread of COVID-19, several millions of diagnostic tests are required daily in just the United States alone.

13 Jan 2021

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

DiosCURE SE announced a publication in Science describing its core technology of multivalent single-chain antibodies with a unique molecular mode-of-action to inactivate SARS-CoV-2 virions. An international team led by scientists at the University of Bonn developed and characterized the lead candidates, which are exclusively licensed by DiosCURE.

13 Jan 2021

Study shows how neurons can become a target of SARS-CoV-2 infection

Using both mouse and human brain tissue, researchers at Yale School of Medicine have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus's effects on brain cells.

13 Jan 2021

Cardiovascular deaths unrelated to COVID-19 increased during the pandemic, study finds

As the number of COVID-19 infections continues to rise nationwide, more than 360,000 Americans have already died from the potentially deadly viral infection.

13 Jan 2021

Open-faced helmet contains pathogen-bearing droplets, reduces transmission to medical specialists

The risk of infection of COVID-19 is high for medical specialists who come in contact with symptomatic or asymptomatic patients.

13 Jan 2021

Study: Testing policies should vary based on demand to catch the most COVID-19 cases

With months to go in the mass rollout of COVID-19 vaccines, testing is still critical to control the surging pandemic.

13 Jan 2021

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

A short paper that appeared recently on the preprint bioRxiv server pointed to a link between specific characteristics of anti-SARS-CoV-2 antibodies associated with the severity of COVID-19.

12 Jan 2021

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

A new preprint that appeared on the bioRxiv server reports that intranasal vaccination with the D614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus monkeys reduces viral shedding. This is an experiment in non-human primates (NHP), and its extrapolation to humans is unclear as yet.

12 Jan 2021

Structure of SARS-CoV-2 cytoplasmic tail uncovered

The virus's cytosolic tail also interacts with the host cell to promote its entry into the endoplasmic reticulum (ER). A new study appearing on the bioRxiv preprint server elucidates the conformation of this region of the virus, which will help understand how its form is related to its function in viral entry.

12 Jan 2021

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization.

12 Jan 2021

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the pathogen responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Approximately 20-55% of hospitalized COVID-19 patients are reported to have deranged hemostatic laboratory parameters, which suggests coagulopathy.

12 Jan 2021

Antigenic "supersite" could improve design of COVID-19 vaccines

Researchers in the United States have defined an antigenic “supersite” within the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could have important implications for the design of vaccines to protect against coronavirus disease 2019 (COVID-19).

12 Jan 2021

Study reveals rising risk of mental health problems among COVID-19 health care professionals

The daily toll of COVID-19, as measured by new cases and the growing number of deaths, overlooks a shadowy set of casualties: the rising risk of mental health problems among health care professionals working on the frontlines of the pandemic.

12 Jan 2021

Hypoxia signaling pathway could lead to COVID-19 treatments

Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19).

12 Jan 2021

K-State medical director contributes to research on SARS-CoV-2 transmission and quarantine periods

Kyle Goerl, the medical director of Kansas State University's Lafene Health Center, is part of a collaborative team that is providing research-based guidance during the COVID-19 pandemic.

12 Jan 2021

Leading pediatric hospital reveals top AI models in COVID-19 Grand Challenge

The top 10 results have been unveiled in the first-of-its-kind COVID-19 Lung CT Lesion Segmentation Grand Challenge, a groundbreaking research competition focused on developing artificial intelligence (AI) models to help in the visualization and measurement of COVID specific lesions in the lungs of infected patients, potentially facilitating to more timely and patient-specific medical interventions.

12 Jan 2021

Poor gut health may adversely affect COVID-19 prognosis

People infected with COVID-19 experience a wide range of symptoms and severities, the most commonly reported including high fevers and respiratory problems.

12 Jan 2021

Atmospheric particulate matter may influence the transmission and evolution of SARS-CoV-2

A recent study conducted at the University of Malta Medical School, Malta, has revealed that a drop in the level of particulate matter 2.5 (PM2.5), which are airborne pollutant particles with a diameter of 2.5 micrometer, in the atmosphere due to lockdown is associated with the arrival of a newer variant of SARS-CoV-2, which has eventually displaced the original virus after lockdown.

12 Jan 2021

Endothelial tissue injury significantly contributes to ARDS in COVID-19 patients, finds study

A recent study conducted by scientists from the Yokohama City University, Japan, has revealed that elevated alveolar endothelial injury markers in coronavirus disease 2019 (COVID-19) patients with acute respiratory distress syndrome (ARDS) are the main causative factors for alveolar barrier disruption. In COVID-19 patients with ARDS, endothelial injury persists for a longer time than epithelial injury.

12 Jan 2021

Will the Pfizer–BioNTech vaccine be effective against the new N501Y SARS-CoV-2 variant?

Researchers from Pfizer and the University of Texas, USA, have presented evidence showing that people in a previously reported trial of the mRNA-based COVID-19 vaccine, BNT162b2 – commonly known as the Pfizer-BioNTech COVID-19 vaccine – had equivalent neutralizing titers to the N501 and Y501 viruses.

12 Jan 2021

Disease/Infection News

FAU researchers develop simplified, rapid SARS-CoV-2 detection protocol

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

Study shows how neurons can become a target of SARS-CoV-2 infection

Cardiovascular deaths unrelated to COVID-19 increased during the pandemic, study finds

Open-faced helmet contains pathogen-bearing droplets, reduces transmission to medical specialists

Study: Testing policies should vary based on demand to catch the most COVID-19 cases

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

Structure of SARS-CoV-2 cytoplasmic tail uncovered

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

Antigenic "supersite" could improve design of COVID-19 vaccines

Study reveals rising risk of mental health problems among COVID-19 health care professionals

Hypoxia signaling pathway could lead to COVID-19 treatments

K-State medical director contributes to research on SARS-CoV-2 transmission and quarantine periods

Leading pediatric hospital reveals top AI models in COVID-19 Grand Challenge

Poor gut health may adversely affect COVID-19 prognosis

Atmospheric particulate matter may influence the transmission and evolution of SARS-CoV-2

Endothelial tissue injury significantly contributes to ARDS in COVID-19 patients, finds study

Will the Pfizer–BioNTech vaccine be effective against the new N501Y SARS-CoV-2 variant?

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich

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