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A comprehensive clinical and genetic model for predicting severe COVID-19 risk

While determining the risk of severe COVID-19, age, and gender are usually the only considerations. A recent preprint paper published in medRxiv, discusses how researchers from Genetic Technologies Limited, Australia, used the UK Biobank data to develop a comprehensive model that can predict severe COVID-19 risk by incorporating comorbidity risk factors, demographic information, and a set of genetic markers.

4 Oct 2020

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

A large group of researchers from the United States reported developing an amplification-free CRISPR-based mobile phone assay for direct detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from nasal swabs. Their state-of-the-art paper is currently available on the medRxiv* preprint server.

4 Oct 2020

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

In a new bioRxiv* preprint paper, researchers from the Imperial College London, King's College London, and the University of Bristol in the United Kingdom show that the furin cleavage site of SARS-CoV-2 spike glycoprotein represents a key determinant for transmission among humans, as it substantially facilitates replication in airway cells - opening the door for the development of novel therapeutics.

4 Oct 2020

Identifying cardiopulmonary processes involved in severe COVID-19

Researchers in the United States have identified cardiopulmonary processes that may partly explain why some individuals with coronavirus disease 2019 (COVID-19) develop respiratory failure.

4 Oct 2020

Modeling viral clades improves prediction of COVID-19 growth rates

A new study conducted by researchers at the University of Connecticut has revealed a correlation between the prevalence of particular clades of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the growth rate of the associated illness coronavirus disease 2019 (COVID-19).

4 Oct 2020

Shedding light on origin, transmission, spread of COVID-19 in Norfolk

Researchers in the UK have conducted a large-scale whole-genome sequencing study of clinical samples positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Norfolk area to shed light on the origins, genetic variation, transmission, and spread of the virus in the region.

4 Oct 2020

Anti-sense agents suppress SARS-CoV-2 virus

Researchers in the United States have conducted a study showing that anti-sense agents called peptide-conjugated morpholino oligomers (PPMOs) have the ability to specifically and potently suppress the growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

4 Oct 2020

Parkinson's disease is an independent risk factor for dying from COVID-19, study suggests

A new study of approximately 80,000 patients shows that people with Parkinson's disease (PD) have a 30% higher risk of dying from COVID-19 than people without the neurodegenerative condition.

1 Oct 2020

PATH wins grant to develop oral treatment option for soil-transmitted helminth infections

PATH announced today they received a grant from Japan's Global Health Innovative Technology Fund to develop a new oral treatment option for soil-transmitted helminth infections.

1 Oct 2020

New AGA report details effectiveness and safety of fecal microbiota transplantation

Today, the American Gastroenterological Association released the first results from the NIH-funded AGA Fecal Microbiota Transplantation National Registry, the largest real-world study on the safety and effectiveness of FMT.

1 Oct 2020

Combinational therapy with antibiotics and stem cells effectively treats bone infections

Bone infections caused by implants are difficult to treat and usually require a prolonged course of antibiotic treatment.

1 Oct 2020

New multiplexed test with a low-cost sensor may enable at-home COVID diagnosis

One feature of the COVID-19 virus that makes it so difficult to contain is that it can be easily spread to others by a person who has yet to show any signs of infection.

1 Oct 2020

Researchers develop AI algorithm to evaluate chest X-rays for COVID-19 diagnosis

A team of researchers at the University of Minnesota recently developed and validated an artificial intelligence algorithm that can evaluate chest X-rays to diagnose possible cases of COVID-19.

1 Oct 2020

Study provides in-depth analysis on VTE risk in COVID-19 patients

In a systematic review of the worldwide published data on "Venous thromboembolism (VTE) in COVID-19 patients", Cihan Ay, Stephan Nopp, and Florian Moik from the Department of Medicine I, Clinical Division of Haematology and Haemostaseology, now for the first time, provide an in-depth analysis on the risk of VTE in patients hospitalized for COVID-19.

1 Oct 2020

Biometric smartwatch data could accurately detect earliy signs of COVID-19

Certain changes in a person's heart and breathing rates could precede symptoms of COVID-19, an increasing number of studies suggests.

1 Oct 2020

New study investigates hospital cardiac arrest in people with COVID-19 infection

Even when a sudden cardiac arrest happens inside a top hospital, where a code blue team is readily available, most people won't survive.

1 Oct 2020

New commitments from governments and organizations support a unified approach to end pandemic

New commitments from governments, international organizations and the private sector support unified approach to end pandemic, backing a response of unprecedented scale, scope and speed - through the Access to COVID-19 Tools Accelerator - as pandemic claims more than 1 million lives

1 Oct 2020

Work bubbles can help reduce risk of company-wide COVID-19 outbreaks

Creating "work bubbles" during the COVID-19 pandemic can help reduce the risk of company-wide outbreaks while helping essential businesses continue to function, as the example of Bombardier Aviation demonstrates in an analysis published in CMAJ (Canadian Medical Association Journal).

1 Oct 2020

Children are active transmitters of COVID-19, shows study

A team of investigators from CDDEP, the Government of Tamil Nadu, and Andhra Pradesh studied disease transmission patterns in 575,071 individuals exposed to 84,965 confirmed cases of COVID-19.

1 Oct 2020

Long-term care system in British Columbia minimizes SARS-CoV-2 transmission

British Columbia found that BC was better prepared for the pandemic and responded in a more coordinated and decisive manner, leading to far fewer deaths than in Ontario.

1 Oct 2020

Disease/Infection News

A comprehensive clinical and genetic model for predicting severe COVID-19 risk

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

Identifying cardiopulmonary processes involved in severe COVID-19

Modeling viral clades improves prediction of COVID-19 growth rates

Shedding light on origin, transmission, spread of COVID-19 in Norfolk

Anti-sense agents suppress SARS-CoV-2 virus

Parkinson's disease is an independent risk factor for dying from COVID-19, study suggests

PATH wins grant to develop oral treatment option for soil-transmitted helminth infections

New AGA report details effectiveness and safety of fecal microbiota transplantation

Combinational therapy with antibiotics and stem cells effectively treats bone infections

New multiplexed test with a low-cost sensor may enable at-home COVID diagnosis

Researchers develop AI algorithm to evaluate chest X-rays for COVID-19 diagnosis

Study provides in-depth analysis on VTE risk in COVID-19 patients

Biometric smartwatch data could accurately detect earliy signs of COVID-19

New study investigates hospital cardiac arrest in people with COVID-19 infection

New commitments from governments and organizations support a unified approach to end pandemic

Work bubbles can help reduce risk of company-wide COVID-19 outbreaks

Children are active transmitters of COVID-19, shows study

Long-term care system in British Columbia minimizes SARS-CoV-2 transmission

Todd Bauman and Chris Povich

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

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