Drug Discovery & Pharmaceuticals

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Novel method can test the efficacy of antibacterial drugs on infectious microbes

A rapid and simple method for testing the efficacy of antibacterial drugs on infectious microbes has been developed and validated by a team of Penn State researchers.

21 Oct 2020

NMR Metabolomics as Novel Screening Tool for New-borns (For Research Only)

In this interview, Oscar Millet, group leader of the Precision Medicine and Metabolism group of the CIC bioGUNE, talked to News Medical about his research into the use of nuclear magnetic resonance spectroscopy (NMR) metabolomic analysis as a clinical screening tool. His team has used NMR to screen urine samples form new-borns for congenital metabolic disorders.

From Bruker BioSpin - NMR, EPR and Imaging 20 Oct 2020

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain could guide design of antiviral agents

The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continues to cause human infection and mortality worldwide. Currently, there are no specific viral protein-targeted therapeutics available.

20 Oct 2020

Researchers develop a molecular docking based webserver to predict drug targets

A highly effective drug therapy is urgently required to combat coronavirus disease 2019 (COVID-19). The authors of this article have developed a molecular docking based webserver, namely D3Targets-2019-nCoV, with two functions, one is for predicting drug targets for drugs or active compounds observed from clinic or in vitro/in vivo studies, the other is for identifying lead compounds against potential drug targets via docking.

20 Oct 2020

Researchers describe how to assess if an antibiotic has a new mechanism of action

The fight against bacterial infections, especially those caused by resistant pathogens, is in full swing with the search for new antibiotic agents.

19 Oct 2020

Combination of peptides and antibiotics could be key to eliminating Leishmania parasites

A combination of peptides and antibiotics could be key to eliminating the parasite causing leishmaniasis and avoiding the toxicity to people and animals caused by current drugs.

16 Oct 2020

Antispastic drug candidate could offer new hope for millions of patients suffering from spasticity

First-in-class antispastic drug candidate to reach clinical phase is published in the prestigious life science journal, Cell. Drug candidate MPH-220 could mean new hope for millions of patients suffering from spasticity.

16 Oct 2020

Bacterial toxin stimulates tissue regeneration

Normally they are among the many harmless organisms found in and on the human body: one in four people have millions of Staphylococcus aureus bacteria on their skin and on the mucous membranes of the upper respiratory tract, without being aware of it.

13 Oct 2020

Study examines the pharmacogenomics of opioid addiction

In one of the first studies of its kind, a University of Cincinnati researcher is using a grant from the Ohio attorney general's office to research the pharmacogenomics of opioid addiction.

13 Oct 2020

Powerful antimicrobial molecules engineered from toxic proteins in wasp venom

A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom.

12 Oct 2020

Chemists suggest a new domino reaction to produce organic compounds against cancers

A team of chemists from RUDN University suggested a new reaction to produce organic compounds in one vessel.

9 Oct 2020

New efficacies of Ganoderma lucidum as anti-inflammatory agent for the skin

Ganoderma lucidum, known as Yeongji mushroom in Korea, is called a modern-day elixir plant and has long been used medicinally in China, Japan and Korea.

7 Oct 2020

New deep learning-based technique could boost drug development

When you take a medication, you want to know precisely what it does. Pharmaceutical companies go through extensive testing to ensure that you do.

5 Oct 2020

Supporting Coronavirus Research with Liquid Chromatography

The RNA in viruses such as SARS-CoV-2 are an ideal research target. RNA purification with liquid chromatography is essential in the fight against SARS-CoV-2.

From KNAUER Wissenschaftliche Geräte GmbH 5 Oct 2020

Study offers explanation for why people's responses to the same drug vary widely

Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.

1 Oct 2020

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

The U.S. Food and Drug Administration has granted Fast Track designation to a novel "switchable" CAR-T cell therapy developed by Calibr, a division of Scripps Research, in a move to accelerate the drug development and review process.

1 Oct 2020

Compounds repurposed from malaria treatment can kill diarrheal pathogen

A class of compounds used for malaria treatment also kill the intestinal parasite Cryptosporidium, a leading cause of diarrheal disease and death in children that has no cure, a multi-institution collaboration of researchers found in a new study.

1 Oct 2020

Planaria flatworm can be used as reliable alternative for testing topical skin products

Tests for skin treatments could be screened using flatworms rather than other animals such as rabbits, according to new research.

1 Oct 2020

Researchers create drug-like compounds to destroy coronavirus' frameshifting element

Scripps Research chemist Matthew Disney, PhD, and colleagues have created drug-like compounds that, in human cell studies, bind and destroy the pandemic coronavirus' so-called "frameshifting element" to stop the virus from replicating.

30 Sep 2020

Naturally occurring enzyme holds potential as low-cost therapeutic to treat COVID-19

Researchers from UCLA and China have found that catalase, a naturally occurring enzyme, holds potential as a low-cost therapeutic drug to treat COVID-19 symptoms and suppress the replication of coronavirus inside the body.

29 Sep 2020

Drug Discovery & Pharmaceuticals

Novel method can test the efficacy of antibacterial drugs on infectious microbes

NMR Metabolomics as Novel Screening Tool for New-borns (For Research Only)

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain could guide design of antiviral agents

Researchers develop a molecular docking based webserver to predict drug targets

Researchers describe how to assess if an antibiotic has a new mechanism of action

Combination of peptides and antibiotics could be key to eliminating Leishmania parasites

Antispastic drug candidate could offer new hope for millions of patients suffering from spasticity

Bacterial toxin stimulates tissue regeneration

Study examines the pharmacogenomics of opioid addiction

Powerful antimicrobial molecules engineered from toxic proteins in wasp venom

Chemists suggest a new domino reaction to produce organic compounds against cancers

New efficacies of Ganoderma lucidum as anti-inflammatory agent for the skin

New deep learning-based technique could boost drug development

Supporting Coronavirus Research with Liquid Chromatography

Study offers explanation for why people's responses to the same drug vary widely

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

Compounds repurposed from malaria treatment can kill diarrheal pathogen

Planaria flatworm can be used as reliable alternative for testing topical skin products

Researchers create drug-like compounds to destroy coronavirus' frameshifting element

Naturally occurring enzyme holds potential as low-cost therapeutic to treat COVID-19

Leveraging the Radian ASAP in standard casework

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Latest Life Science News