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New first line combination therapy shows promising results in patients with advanced NSCLC

A new combination therapy for the first line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) improves progression-free survival (PFS), according to results of phase III IMpower150 trial presented at the ESMO Immuno Oncology Congress 2017.

7 Dec 2017

Investigational ZPIV vaccine found to be safe and immunogenic in trial participants

The investigational Zika purified inactivated virus (ZPIV) vaccine was well-tolerated and induced an immune response in participants, according to initial results from three Phase 1 clinical trials.

5 Dec 2017

New drugs Erenumab and Fremanezumab show promise for migraine

Migraine headaches affect thousands of Americans and millions worldwide. There are several medications that are being prescribed for migraines and for many these do not work well.

30 Nov 2017

New immunotherapy study shows positive results in chronic migraine sufferers

A new study of fremanezumab, an immunotherapy that counteracts one of the molecules released during migraine, was found successful in reducing the number of days that chronic migraine sufferers experienced headaches.

30 Nov 2017

Synthetic cannabis-like drug found to be safe and effective in treating sleep apnea

A synthetic cannabis-like drug in a pill was safe and effective in treating obstructive sleep apnea in the first large multi-site study of a drug for apnea funded by the National Institutes of Health. The study was conducted at Northwestern Medicine and the University of Illinois at Chicago.

28 Nov 2017

New cancer drug begins clinical trial in human patients with rare brain tumor

A drug that spurs cancer cells to self-destruct has been cleared for use in a clinical trial of patients with anaplastic astrocytoma, a rare malignant brain tumor, and glioblastoma multiforme, an aggressive late-stage cancer of the brain.

28 Nov 2017

New study tests pain treatment in humans

Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family, and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain.

27 Nov 2017

Researchers question exclusion of people with prior cancer history from clinical trials

A quarter of newly diagnosed cancer patients 65 or older are survivors who had a prior cancer – often preventing them from participating in clinical trials, researchers from UT Southwestern's Simmons Cancer Center have found.

22 Nov 2017

Trial shows apple allergen as effective treatment option for birch pollen-related apple allergy

The food allergy, which is related to birch pollen, is a very common attendant phenomenon associated with birch pollen allergy - indeed around 70% of those with a birch pollen allergy are also allergic to apples. That amounts to around 280,000 people in Austria.

20 Nov 2017

Study: Alectinib 600 mg more effective than standard therapy in Asian ALK positive NSCLC patients

A subanalysis of the phase III ALEX study has shown that alectinib 600 mg twice daily is more effective than standard of care crizotinib in Asian patients with anaplastic lymphoma kinase (ALK) positive non-small-cell lung cancer (NSCLC), researchers report at the ESMO Asia 2017 Congress.

20 Nov 2017

Osimertinib provides progression-free survival benefit to Asian patients with EGFR-mutated NSCLC

Osimertinib improves progression-free survival compared to standard first line therapy in Asian patients with EGFR-mutated non-small-cell lung cancer (NSCLC), according to the Asian subset analysis of the FLAURA trial presented at the ESMO Asia 2017 Congress, sumultaneously published in The New England Journal of Medicine.

20 Nov 2017

Study confirms safety and efficacy of new second line treatment for metastatic colorectal cancer

A randomized trial in 650 patients has confirmed the safety and efficacy of a new second line treatment for metastatic colorectal cancer, researchers report at the ESMO Asia 2017 Congress.

20 Nov 2017

Machine learning could detect therapeutic effects with greater sensitivity than conventional tests

Machine learning could improve our ability to determine whether a new drug works in the brain, potentially enabling researchers to detect drug effects that would be missed entirely by conventional statistical tests, finds a new UCL study published in Brain.

15 Nov 2017

PCSK9 inhibitor offers clinical benefit to patients with peripheral artery disease

Patients with peripheral artery disease (PAD) are at high risk of heart attack, stroke and cardiovascular death. In addition, PAD patients can suffer major adverse limb events, such as acute limb ischemia - the equivalent of a heart attack in the leg - that can lead to limb loss.

14 Nov 2017

New drug offers hope for osteoarthritis patients suffering from debilitating hand pain

Osteoarthritis is the most prevalent arthritis worldwide and is characterized by chronic pain and impaired physical function.

13 Nov 2017

Ozanimod effective against multiple sclerosis, enters New Drug Approval process with FDA

Celgene Corporation recently announced results from two phase 3 trials evaluating the efficacy and safety of the drug ozanimod.

10 Nov 2017

New gene therapy trial for X-linked myotubular myopathy offers hope to children

Ann & Robert H. Lurie Children's Hospital of Chicago is one of the few centers participating in ASPIRO, an international Phase 1/2 clinical trial of a gene therapy product called AT132 for X-linked myotubular myopathy – a rare disease characterized by severe muscle weakness, breathing difficulty and early death.

8 Nov 2017

New category of immunotherapy appears safe to use in patients with both cancer and HIV

A new category of immunotherapies called checkpoint inhibitors that has been highly effective against many different cancers appears safe to use in patients with both advanced malignancies and HIV, a population excluded from earlier trials of such therapies, according to an early-phase trial.

7 Nov 2017

FDA approves first targeted cancer treatment based on basket study

The US Food and Drug Administration has announced that it has approved the drug vemurafenib for the treatment of patients with BRAF V600-mutant Erdheim-Chester disease (ECD).

7 Nov 2017

Drug can safely and effectively help infants with SMA gain muscle function, study shows

More than half of the babies with infantile-onset spinal muscular atrophy (SMA) who were treated with nusinersen (Spinraza) gained motor milestones, compared to none of the babies in the control group. Infants treated with the drug also had 63 percent lower risk of death.

6 Nov 2017

Drug Trial News

New first line combination therapy shows promising results in patients with advanced NSCLC

Investigational ZPIV vaccine found to be safe and immunogenic in trial participants

New drugs Erenumab and Fremanezumab show promise for migraine

New immunotherapy study shows positive results in chronic migraine sufferers

Synthetic cannabis-like drug found to be safe and effective in treating sleep apnea

New cancer drug begins clinical trial in human patients with rare brain tumor

New study tests pain treatment in humans

Researchers question exclusion of people with prior cancer history from clinical trials

Trial shows apple allergen as effective treatment option for birch pollen-related apple allergy

Study: Alectinib 600 mg more effective than standard therapy in Asian ALK positive NSCLC patients

Osimertinib provides progression-free survival benefit to Asian patients with EGFR-mutated NSCLC

Study confirms safety and efficacy of new second line treatment for metastatic colorectal cancer

Machine learning could detect therapeutic effects with greater sensitivity than conventional tests

PCSK9 inhibitor offers clinical benefit to patients with peripheral artery disease

New drug offers hope for osteoarthritis patients suffering from debilitating hand pain

Ozanimod effective against multiple sclerosis, enters New Drug Approval process with FDA

New gene therapy trial for X-linked myotubular myopathy offers hope to children

New category of immunotherapy appears safe to use in patients with both cancer and HIV

FDA approves first targeted cancer treatment based on basket study

Drug can safely and effectively help infants with SMA gain muscle function, study shows

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