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New clinical trial initiated on experimental vaccine to stop the spread of glioblastoma

Rush University Medical Center is part of a new clinical trial testing whether an experimental vaccine can help patients' immune systems stop the spread of glioblastoma -- an aggressive form of brain cancer with veryhttps://www.rush.edu/news/press-releases/rush-testing-new-brain-cancer-vaccine few current treatment options.

14 Sep 2018

Clinical trial begins to find better treatment for chronic cases of PKDL in Africa

A clinical trial to find a better treatment for severe or chronic cases of post kala-azar dermal leishmaniasis (PKDL) in Africa has begun in Dooka, Sudan.

12 Sep 2018

Mycovia initiates two Phase 3 clinical trials to evaluate VT-1161 in patients with RVVC

Mycovia Pharmaceuticals, making its official debut as a company developing therapies in women's health and dermatology, today announced the initiation of two Phase 3 clinical trials called VIOLET to evaluate the safety and efficacy of its lead candidate, VT-1161, in patients with recurrent vulvovaginal candidiasis

6 Sep 2018

Verastem doses first patient in Phase I/II clinical trial of duvelisib in combination with venetoclax

Verastem, Inc., operating as Verastem Oncology, a biopharmaceutical company focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced dosing of the first patient in a multicenter Phase I/II clinical trial at the Dana-Farber/Harvard Cancer Center of duvelisib in combination with venetoclax in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

6 Sep 2018

Phase 1 clinical trial examining topical cream plus influenza vaccine is underway

A Phase 1 clinical trial examining whether a topical cream can enhance the immune response conferred by a "pre-pandemic" influenza vaccine is underway at Baylor College of Medicine in Houston.

6 Sep 2018

Phase 2 clinical study reports best outcomes to date for older Hodgkin lymphoma patients

Recently published results of a phase 2 clinical trial have shown the best outcomes to date for newly diagnosed older Hodgkin lymphoma patients treated with brentuximab vedotin given before and after doxorubicin, vinblastine and dacarbazine chemotherapy, which is the standard of care.

5 Sep 2018

Arrowhead completes dosing of ARO-AAT Phase 1 study to treat rare genetic liver disease

Arrowhead Pharmaceuticals Inc. today announced that it has completed dosing of a Phase 1 clinical study of ARO-AAT, the company's second generation subcutaneously administered RNA interference therapeutic being developed as a treatment for a rare genetic liver disease associated with alpha-1 antitrypsin deficiency.

31 Aug 2018

Almost half of total funding for publication of clinical trials is not disclosed, finds research

A substantial proportion of pharmaceutical industry payments to authors of oncology clinical trials published in major scientific journals are not disclosed, new research shows. The publications focused on clinical trials that tested new cancer drugs.

31 Aug 2018

Leukogene receives STTR grant to optimize compound for treatment-resistant multiple myeloma

A $2 million phase 2 Small Business Technology Transfer grant to optimize a promising new compound that has shown efficacy in preclinical studies against treatment-resistant multiple myeloma has been awarded to a Medical University of South Carolina startup company, Leukogene Therapeutics, Inc., in collaboration with MUSC researcher and company founder, Nathan G. Dolloff, Ph.D. Dolloff is an assistant professor in the Department of Cell and Molecular Pharmacology & Experimental Therapeutics at MUSC and a member of MUSC Hollings Cancer Center.

31 Aug 2018

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Pfizer Inc. announced today that it is terminating two ongoing clinical studies evaluating domagrozumab (PF-06252616) for the treatment of Duchenne muscular dystrophy (DMD): a Phase 2 safety and efficacy study (B5161002) and an open-label extension study (B5161004).

30 Aug 2018

Eagle Pharmaceuticals completes enrollment of second clinical study to evaluate safety, efficacy of RYANODEX

Eagle Pharmaceuticals, Inc. today announced completion of enrollment of the Company's second clinical study to further evaluate the safety and efficacy of RYANODEX® (dantrolene sodium for injectable suspension) for the treatment of exertional heat stroke, an investigational new indication for the product.

30 Aug 2018

Clinical trial: Promising drug slows brain shrinkage in progressive MS patients

A promising drug slowed brain shrinkage in progressive multiple sclerosis (MS) by nearly half, according to new research led by Cleveland Clinic. Very limited therapies are currently available for this disabling form of the disease.

30 Aug 2018

TB Alliance initiates SimpliciTB to test if new four-drug regimen can treat most types of tuberculosis

TB Alliance has initiated a pivotal clinical trial, SimpliciTB, that will evaluate whether a new four-drug regimen can treat most types of tuberculosis including multidrug-resistant TB more quickly and effectively than currently-available treatments.

28 Aug 2018

Researchers launch clinical trial to assess new drug combination against metastatic breast cancers

Researchers at University of California San Diego School of Medicine have launched a phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or locally advanced breast cancer that cannot be surgically removed.

28 Aug 2018

Study demonstrates cardiovascular safety of weight loss drug

A weight loss drug does not increase cardiovascular events, according to late breaking results from the CAMELLIA-TIMI 61 trial presented today in a Hot Line Session at ESC Congress and published in the New England Journal of Medicine.

27 Aug 2018

Forbius receives $18.75 million grant from CPRIT for Phase 2a development of AVID100

Forbius announced today that it has been awarded a Product Development grant totaling $18.75 million from the Cancer Prevention and Research Institute of Texas.

25 Aug 2018

UAB receives NIH grant to continue evaluation of new medication for IPF

The University of Alabama at Birmingham has received a grant from the National Institutes of Health totaling $8.9 million to fund a multiyear program evaluating the role of a new medication in a clinical trial for patients suffering from idiopathic pulmonary fibrosis

24 Aug 2018

Researchers complete testing a new drug to treat rheumatoid arthritis

An international research group led by Charité - Universitätsmedizin Berlin has completed testing a new drug to treat rheumatoid arthritis.

23 Aug 2018

Immunotherapy combination shrinks melanoma that has spread to the brain

Combination immunotherapy shrank melanoma that has spread to the brain in more than half of the patients in a clinical trial reported in the New England Journal of Medicine led by an investigator at The University of Texas MD Anderson Cancer Center.

23 Aug 2018

Scientists publish study results of AAV therapy product for treatment of RHO-adRP

Ophthotech Corporation announced today that scientists at the University of Pennsylvania and University of Florida published proof-of-concept study results on an adeno-associated virus gene therapy product candidate for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa licensed by Ophthotech.

22 Aug 2018

Drug Trial News

New clinical trial initiated on experimental vaccine to stop the spread of glioblastoma

Clinical trial begins to find better treatment for chronic cases of PKDL in Africa

Mycovia initiates two Phase 3 clinical trials to evaluate VT-1161 in patients with RVVC

Verastem doses first patient in Phase I/II clinical trial of duvelisib in combination with venetoclax

Phase 1 clinical trial examining topical cream plus influenza vaccine is underway

Phase 2 clinical study reports best outcomes to date for older Hodgkin lymphoma patients

Arrowhead completes dosing of ARO-AAT Phase 1 study to treat rare genetic liver disease

Almost half of total funding for publication of clinical trials is not disclosed, finds research

Leukogene receives STTR grant to optimize compound for treatment-resistant multiple myeloma

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Eagle Pharmaceuticals completes enrollment of second clinical study to evaluate safety, efficacy of RYANODEX

Clinical trial: Promising drug slows brain shrinkage in progressive MS patients

TB Alliance initiates SimpliciTB to test if new four-drug regimen can treat most types of tuberculosis

Researchers launch clinical trial to assess new drug combination against metastatic breast cancers

Study demonstrates cardiovascular safety of weight loss drug

Forbius receives $18.75 million grant from CPRIT for Phase 2a development of AVID100

UAB receives NIH grant to continue evaluation of new medication for IPF

Researchers complete testing a new drug to treat rheumatoid arthritis

Immunotherapy combination shrinks melanoma that has spread to the brain

Scientists publish study results of AAV therapy product for treatment of RHO-adRP

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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