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New clinical trial to examine safety of checkpoint inhibitor in pediatric cancer patients

In an innovative, first-in-pediatrics study, available only at Children's Hospital Los Angeles, researchers will be enrolling children between 1 and 18 years of age who have certain types of relapsed or treatment-resistant cancer.

18 Aug 2016

BCL-2 inhibitor shows promise in AML patients

Patients whose acute myelogenous leukemia (AML) had relapsed or was resistant to chemotherapy and those who were deemed unable to tolerate chemotherapy experienced responses to the selective BCL-2 inhibitor venetoclax (Venclexta), with complete remissions in some, according to phase II clinical trial data.

12 Aug 2016

CTCA at Western begins clinical trial for novel antibody to treat patients with advanced tumors

Cancer Treatment Centers of America at Western Regional Medical Center has dosed its first three patients as part of the launch of a Phase I clinical trial using a novel antibody to treat patients with advanced solid tumors.

8 Aug 2016

Study demonstrates significant reduction in severity of exercise-induced asthma following B-GOS consumption

Clasado Biosciences Limited, the producers and suppliers of Bimuno(R) (B-GOS), a unique patented trans-galactooligosaccharide complex, today announces the publication of results for the latest clinical study using B-GOS.

5 Aug 2016

NIH launches clinical trial of experimental vaccine candidate for preventing Zika virus infection

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has launched a clinical trial of a vaccine candidate intended to prevent Zika virus infection.

3 Aug 2016

Combination therapy shows no better benefits than placebo for patients with knee osteoarthritis

Chondroitin sulfate (CS) plus glucosamine sulfate (GS) was no better than placebo for reducing pain and function impairment in a multicenter, randomized, double-blinded, placebo-controlled study of 164 patients with knee osteoarthritis.

2 Aug 2016

NIAID begins early-stage trial of experimental vaccine for preventing yellow fever virus

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has begun an early-stage clinical trial of an investigational vaccine designed to protect against yellow fever virus.

27 Jul 2016

Duke to lead early-stage clinical trials for promising new neurological therapies

Duke University could receive up to $19 million to lead early-stage clinical trials for new drugs to treat neurological conditions such as Alzheimer's disease and neuropathy.

22 Jul 2016

Pulmatrix announces positive results from Phase 1 study of novel dry powder formulation in COPD patients

Pulmatrix, Inc., today announced positive topline data from a Phase 1 pilot pharmacokinetic bioavailability trial of PUR0200. PUR0200 is a novel dry powder formulation of a currently marketed once daily bronchodilator, formulated in the company's proprietary iSPERSETM dry powder delivery technology.

22 Jul 2016

Adding new monoclonal antibody to chemotherapy improves survival in soft-tissue sarcoma patients

Adding a novel monoclonal antibody therapy to traditional chemotherapy increased median survival by nearly a year in patients with advanced sarcoma, a lethal soft-tissue cancer.

21 Jul 2016

Study highlights effectiveness of atypical antipsychotic drug in treating children with TD

A meta-analysis of clinical trials evaluating the effectiveness of aripiprazole for the treatment of Tourette's disorder (TD) in children and adolescents showed a significantly greater overall improvement in total tics and tic severity from pretreatment to post-treatment for the aripiprazole compared to the placebo group.

21 Jul 2016

Study reports BV therapy may be curative in some Hodgkin lymphoma patients

Five-year survival data published online today in Blood, the Journal of the American Society of Hematology, suggest that the targeted therapy brentuximab vedotin may have cured some Hodgkin lymphoma patients whose disease has persisted despite receiving previous therapies.

19 Jul 2016

Phase III clinical study of promising prostate cancer drug reveals surprising results

A recently published international clinical Phase III trial of a promising drug for treating advanced prostate cancer ended with surprising results: the new therapeutic agent failed to achieve any significant improvement in the overall survival of patients compared with the established standard treatment.

12 Jul 2016

Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson's disease or dementia with Lewy bodies.

12 Jul 2016

New data shows Sandoz biosimilar etanercept candidate has equivalent efficacy to originator product

Sandoz, a Novartis division, and the pioneer and global leader in biosimilars, today announced results from the EGALITY trial in which the primary endpoint of achieving equivalence in Psoriasis Area and Severity Index (PASI) 75 response rates at week 12 was met.

8 Jul 2016

Clinical trial to test low-dose heparin treatment for patients with ruptured brain aneurysm

A Louisville patient is the first to be enrolled in a national clinical trial to test a new treatment for patients who have suffered a ruptured brain aneurysm.

7 Jul 2016

Clinical trial to evaluate safety of palbociclib drug in African American women with breast cancer

The first clinical trial to test a newly approved breast cancer drug specifically in African American patients is now enrolling at Georgetown Lombardi Comprehensive Cancer Center and will begin soon at five other institutions in Washington, DC, Maryland, Alabama and New Jersey.

7 Jul 2016

European Commission approves extended indication for Amgen's Kyprolis (carfilzomib) for the treatment of relapsed multiple myeloma patients

Amgen has announced that the European Commission (EC) has approved a variation to the marketing authorization for Kyprolis® (carfilzomib) to include use in combination with dexamethasone alone for adult patients with multiple myeloma who have received at least one prior therapy. The extended indication marks the second approval for Kyprolis by the EC in less than a year.

6 Jul 2016

MorphoSys receives clinical milestone for start of Phase 1 trial in prevention of thrombosis with novel antibody

MorphoSys AG announced that it has received a milestone payment from Novartis in connection with the initiation of a clinical phase 1 trial with a novel HuCAL antibody. The antibody will be tested in the field of prevention of thrombosis. This is the twelfth therapeutic antibody based on MorphoSys's technologies that Novartis is evaluating in clinical trials. Financial details were not disclosed.

6 Jul 2016

Quantum Genomics initiates Phase IIa trial for heart failure

Quantum Genomics, a biopharmaceutical company with the mission of developing new therapies for unmet medical needs in the field of cardiovascular diseases, today announced the initiation of its Phase IIa multicentric clinical trial of GQC101, entitled QUID HF (QUantum Genomics Incremental Dosing in Heart Failure), for the treatment of patients with chronic heart failure. The first three clinical centres of the European trial have been opened in France and Norway.

6 Jul 2016

Drug Trial News

New clinical trial to examine safety of checkpoint inhibitor in pediatric cancer patients

BCL-2 inhibitor shows promise in AML patients

CTCA at Western begins clinical trial for novel antibody to treat patients with advanced tumors

Study demonstrates significant reduction in severity of exercise-induced asthma following B-GOS consumption

NIH launches clinical trial of experimental vaccine candidate for preventing Zika virus infection

Combination therapy shows no better benefits than placebo for patients with knee osteoarthritis

NIAID begins early-stage trial of experimental vaccine for preventing yellow fever virus

Duke to lead early-stage clinical trials for promising new neurological therapies

Pulmatrix announces positive results from Phase 1 study of novel dry powder formulation in COPD patients

Adding new monoclonal antibody to chemotherapy improves survival in soft-tissue sarcoma patients

Study highlights effectiveness of atypical antipsychotic drug in treating children with TD

Study reports BV therapy may be curative in some Hodgkin lymphoma patients

Phase III clinical study of promising prostate cancer drug reveals surprising results

Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

New data shows Sandoz biosimilar etanercept candidate has equivalent efficacy to originator product

Clinical trial to test low-dose heparin treatment for patients with ruptured brain aneurysm

Clinical trial to evaluate safety of palbociclib drug in African American women with breast cancer

European Commission approves extended indication for Amgen's Kyprolis (carfilzomib) for the treatment of relapsed multiple myeloma patients

MorphoSys receives clinical milestone for start of Phase 1 trial in prevention of thrombosis with novel antibody

Quantum Genomics initiates Phase IIa trial for heart failure

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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