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Moderna COVID-19 vaccine safe and efficacious in adolescents according to a new study

The safety, immunogenicity, and efficacy of the vaccines in adolescents are largely unknown. Now, a new study published in the New England Journal of Medicine evaluates the safety and efficacy of the mRNA-1273 vaccine in adolescents (12-17 years of age).

16 Aug 2021

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Combining a histone deacetylase inhibitor drug with immunotherapy agents is safe, and may benefit some patients with advanced cancers that have not responded to traditional therapy, according to results of a phase 1 clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center, Bloomberg~Kimmel Institute for Cancer Immunotherapy and several other centers including University of Pittsburgh Cancer Institute, Yale Cancer Center and City of Hope in Los Angeles, which participated in study enrollment, and the University of Southern California and University College Cork in Ireland, which collaborated on analysis of the data.

16 Aug 2021

World-first trial of third dose COVID-19 booster vaccine shows improved protection in transplant patients

Scientists with the Ajmera Transplant Centre at UHN have conducted a first-in-the-world randomized placebo-controlled trial of third dose COVID-19 booster vaccine for transplant patients that shows substantially improved protection.

14 Aug 2021

Study helps to clarify the post-clinical trial needs of cancer patients

Cancer clinical trials (CCTs) provide patients an opportunity to receive experimental drugs, tests, and/or procedures that can lead to remissions. For some, a CCT may seem like their only option. Yet little is known about the experiences of patient participants who withdraw from CCTs.

14 Aug 2021

UC Davis joins with Pfizer for COVID-19 booster vaccine trial

As COVID-19 booster shots begin for those with compromised immune systems, researchers at the UC Davis School of Medicine continue to collect data from clinical trial participants.

13 Aug 2021

Study finds durable responses to immunotherapy in rare angiosarcomas

In a small study of 16 patients with the rare cancer angiosarcoma, tumors in four patients partially or completely responded to treatment with a combination of the immunotherapy drugs ipilimumab and nivolumab.

13 Aug 2021

Camelid nanobody anti-SARS-CoV-2 drug candidates

In a research paper recently published in the journal eLife, researchers from several US institutions have developed a nanobody-based candidate drug that effectively prevents and suppresses severe SARS-CoV-2 infection in animals.

12 Aug 2021

Small NIH clinical trial shows that new monoclonal antibody can prevent malaria

One dose of a new monoclonal antibody discovered and developed at the National Institutes of Health safely prevented malaria for up to nine months in people who were exposed to the malaria parasite.

11 Aug 2021

A new promising target for broad-spectrum therapeutics against coronaviruses

A recent study by Canadian and US researchers demonstrates how frameshift signals of coronaviruses represent a viable target for developing novel therapeutics with broad-spectrum activity – not only against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also other constituents of the coronavirus family. The study is currently available on the bioRxiv* preprint server while it undergoes peer review.

11 Aug 2021

Flavonoid-based inhibitors targeting SARS-CoV 3CL protease for the treatment of SARS-CoV-2 infection

A new study has explored a series of potential flavonoid inhibitors targeting 3CL protease of SARS-CoV.

9 Aug 2021

Study of antibody responses to COVID-19 mRNA vaccine in convalescent individuals

In addition to clinical trials conducted to determine the safety and efficacy of the mRNA vaccines, additional studies began describing the serological response to the vaccines under "real-world" conditions, especially with the onset of the SARS-CoV-2 variants and case reports of vaccine escape.

9 Aug 2021

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

A new study describes the structure of a crucial enzyme present in SARS-CoV-2.

8 Aug 2021

Oral drug found to be effective, safe for treating anemia in patients with chronic kidney disease

Pooled results from recent clinical trials indicate that an oral drug called roxadustat is an effective treatment for anemia in patients with chronic kidney disease.

6 Aug 2021

Topical cream shows signs of clinical efficacy in patients with basal cell carcinoma

Remetinostat, a topical cream and first-in-class inhibitor of histone deacetylation, showed signs of clinical efficacy in patients with basal cell carcinoma.

6 Aug 2021

Review highlights barriers to recruiting women into cardiovascular trials and offers solutions

Women must be equally represented in heart disease research to ensure that treatment recommendations meet their specific health needs, according to a report published today in European Heart Journal, a journal of the European Society of Cardiology (ESC).

6 Aug 2021

Common weight-loss drug successfully targets fat in adults with obesity at high cardiovascular risk

Researchers at UT Southwestern announced successful results of a clinical trial for a commonly prescribed weight-loss drug called liraglutide.

4 Aug 2021

Inhibition of SARS-CoV-2 replication in vitro by Losartan

A new study explores the use of Losartan to provide protection against COVID-19 pathogenesis.

3 Aug 2021

Nasal version of AstraZeneca SARS-CoV-2 vaccine prevents infection in animal models

Scientists evaluate the use of ChAdOx1 nCoV-19 as a potential intranasal (IN) vaccine candidate in hamster and rhesus macaque models.

3 Aug 2021

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

The Republic of Belarus Ministry of Health has approved expanding the ongoing clinical trial of CureLab Oncology's Elenagen, an experimental DNA therapy, to include two new arms: 1) hormone-resistant breast cancer; and 2) hormone-resistant metastatic prostate cancer.

3 Aug 2021

Pfizer moves towards an oral anti-COVID-19 therapy

Researchers in the United States have described a novel antiviral agent against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently being evaluated in clinical trials as a treatment for coronavirus disease 2019 (COVID-19).

2 Aug 2021

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Drug Trial News

Moderna COVID-19 vaccine safe and efficacious in adolescents according to a new study

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

World-first trial of third dose COVID-19 booster vaccine shows improved protection in transplant patients

Study helps to clarify the post-clinical trial needs of cancer patients

UC Davis joins with Pfizer for COVID-19 booster vaccine trial

Study finds durable responses to immunotherapy in rare angiosarcomas

Camelid nanobody anti-SARS-CoV-2 drug candidates

Small NIH clinical trial shows that new monoclonal antibody can prevent malaria

A new promising target for broad-spectrum therapeutics against coronaviruses

Flavonoid-based inhibitors targeting SARS-CoV 3CL protease for the treatment of SARS-CoV-2 infection

Study of antibody responses to COVID-19 mRNA vaccine in convalescent individuals

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

Oral drug found to be effective, safe for treating anemia in patients with chronic kidney disease

Topical cream shows signs of clinical efficacy in patients with basal cell carcinoma

Review highlights barriers to recruiting women into cardiovascular trials and offers solutions

Common weight-loss drug successfully targets fat in adults with obesity at high cardiovascular risk

Inhibition of SARS-CoV-2 replication in vitro by Losartan

Nasal version of AstraZeneca SARS-CoV-2 vaccine prevents infection in animal models

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

Pfizer moves towards an oral anti-COVID-19 therapy

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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