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High-dose CIMT produces longer lasting improvements in children with hemiparetic cerebral palsy

Children with hemiparetic cerebral palsy, a movement disorder that affects use of one side of the body, showed improved use of the arm and hand after receiving a high dose of Constraint-Induced Movement Therapy (CIMT) in a clinical trial funded by the National Institutes of Health.

14 Oct 2021

Inactivated polio vaccine induces antibodies that block SARS-CoV-2 RNA synthesis

A new study introduces the possibility that the inactivated polio vaccine can elicit antibodies that inhibit SARS-CoV-2 nucleic acid synthesis.

10 Oct 2021

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

The results of Phase I clinical trials for two new COVID-19 vaccine candidates based on recombinant RDB proteins are reported.

10 Oct 2021

COVID-19 vaccine clinical trial for children is underway in St. Louis

A pediatric COVID-19 vaccine clinical trial is underway in St. Louis. Led by Washington University School of Medicine, about 140 area children will receive the two-shot Moderna vaccine or placebo at St. Louis Children's Hospital as part of a clinical trial involving about 100 medical institutions in the U.S. and Canada.

6 Oct 2021

AstraZeneca COVID-19 vaccine safe and effective in phase 3 U.S., Chile, and Peru trial

A new study reports on the results of phase III clinical trial on the safety and efficacy of the AstraZeneca-Oxford COVID-19 vaccine.

5 Oct 2021

Convalescent plasma is "futile" as COVID-19 treatment for critically ill patients, trial shows

In the earliest days of the COVID-19 pandemic, the medical community turned to a century-old treatment: Take blood from recovered patients and give it to the sick.

4 Oct 2021

J&J vaccine prevents SARS-CoV-2-induced thrombosis and inflammation in hamsters

In a recent study, researchers performed bulk RNA-Seq transcriptomic profiling of lungs from vaccinated and unvaccinated hamsters with the Janssen vaccine.

4 Oct 2021

Researchers launch new study of COVID-19 vaccination schedules in 12-to-16-year-olds

Researchers running the University of Oxford-led Com-COV programme have launched a new study of COVID-19 vaccination schedules in young people aged 12 to 16.

4 Oct 2021

REGEN-COV shown to reduce risk of COVID-19–related hospitalization or death from any cause

The phase 1-2 clinical trials conducted using REGEN-COV had shown promising therapeutic benefits in COVID-19 outpatients. Its effect was further investigated in the present phase 3 clinical trial, the findings of which have been published in the "The New England Journal of Medicine".

3 Oct 2021

Researchers publish new datasets to better train machine learning models for drug discovery

Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions.

2 Oct 2021

Moderna vaccine reduced viral load and protected against SARS-CoV-2 variants in new phase 3 trial

Coronavirus research has shown that higher viral loads are associated with severe COVID-19 infection. But new results from the phase III Coronavirus Efficacy (COVE) clinical trial find the Moderna vaccine reduces severe acute respiratory coronavirus 2 (SARS-CoV-2) viral load and viral shedding.

30 Sep 2021

How effective are COVID-19 vaccines against SARS-CoV-2 variants of concern?

The authors from this paper performed a systematic review and meta-analysis evaluating vaccine effectiveness from RCTs and observational studies.

29 Sep 2021

Clinical study tests novel topical corneal epithelial stem cell-derived product for treating dry eye disease

Several studies conducted over the last decade have concluded that dry eye disease (DED) affects up to 50% of the U.S. population, creating a liability for the nation's health care system that is estimated to exceed $50 billion annually.

28 Sep 2021

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that SAB-185, a novel polyclonal antibody therapy, has demonstrated safety and efficacy in phase 2 that meet the criteria for graduation to phase 3 in the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial (ACTG A5401).

28 Sep 2021

Trial of Sanofi/GSK SARS-CoV-2 vaccine boosters against variants in non-human primates

New research discusses the development of soluble prefusion-stabilized spike trimers (CoV2 preS dTM) comprising adjuvant AS03.

27 Sep 2021

B cell activating anti-CD73 antibody for the immunotherapy of COVID-19

Despite the advent of numerous vaccines and the discovery of passive monoclonal antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there remains an urgent need for definitive therapies for coronavirus disease-2019 (COVID-19) patients.

27 Sep 2021

Promising data from early clinical trials of new anticancer therapies presented at ESMO Congress 2021

Data from early clinical trials presented at the ESMO Congress 2021 suggest that new anticancer treatments are on the horizon, with a clear emphasis on precision medicine.

24 Sep 2021

Research reveals underperformance of many Phase III oncology trials

New research in the September 2021 issue of JNCCN - Journal of the National Comprehensive Cancer Network finds that more than 80% of therapies tested in Phase III oncology trials did not achieve meaningful clinical benefit in prolonging survival.

24 Sep 2021

Novel anti-hormonal therapy may be a new treatment option for early-stage breast cancer

Early results from a UCLA-led clinical trial found treating women with estrogen receptor (ER)-positive and human epidermal growth factor receptor-2 (HER2)-negative early breast cancers with a novel type of anti-hormonal therapy, called an oral selective estrogen receptor degrader (SERD), led to clinically meaningful reductions in tumor activity prior to surgery.

21 Sep 2021

Sunitinib extends progression-free survival in patients with rare neuroendocrine tumor, study shows

The first randomized study in malignant pheochromocytoma and paraganglioma (MPP) has found that sunitinib prolongs progression-free survival (PFS) by more than five months.

20 Sep 2021

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Drug Trial News

High-dose CIMT produces longer lasting improvements in children with hemiparetic cerebral palsy

Inactivated polio vaccine induces antibodies that block SARS-CoV-2 RNA synthesis

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

COVID-19 vaccine clinical trial for children is underway in St. Louis

AstraZeneca COVID-19 vaccine safe and effective in phase 3 U.S., Chile, and Peru trial

Convalescent plasma is "futile" as COVID-19 treatment for critically ill patients, trial shows

J&J vaccine prevents SARS-CoV-2-induced thrombosis and inflammation in hamsters

Researchers launch new study of COVID-19 vaccination schedules in 12-to-16-year-olds

REGEN-COV shown to reduce risk of COVID-19–related hospitalization or death from any cause

Researchers publish new datasets to better train machine learning models for drug discovery

Moderna vaccine reduced viral load and protected against SARS-CoV-2 variants in new phase 3 trial

How effective are COVID-19 vaccines against SARS-CoV-2 variants of concern?

Clinical study tests novel topical corneal epithelial stem cell-derived product for treating dry eye disease

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

Trial of Sanofi/GSK SARS-CoV-2 vaccine boosters against variants in non-human primates

B cell activating anti-CD73 antibody for the immunotherapy of COVID-19

Promising data from early clinical trials of new anticancer therapies presented at ESMO Congress 2021

Research reveals underperformance of many Phase III oncology trials

Novel anti-hormonal therapy may be a new treatment option for early-stage breast cancer

Sunitinib extends progression-free survival in patients with rare neuroendocrine tumor, study shows

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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