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Trial reveals effectiveness of axi-cel as first-line treatment for high-risk lymphoma

Results from the ZUMA-12 trial led by researchers at The University of Texas MD Anderson Cancer Center showed that first-line treatment with axicabtagene ciloleucel (axi-cel), a chimeric antigen receptor (CAR) T cell therapy, achieved a high rate of complete response in patients with high-risk large B-cell lymphoma (LBCL).

21 Mar 2022

Trial shows safety and immunogenicity of immunotherapy with chemoradiation in cervical cancer patients

A Phase I/Ib trial conducted by the National Cancer Institute (NCI) National Clinical Trials Network (NCTN) group NRG Oncology, NRG-GY017, concluded that the addition of the immunotherapy drug atezolizumab prior to and concurrently given with chemoradiation (CRT) treatment was safe for women with node-positive, locally advanced cervical cancer.

19 Mar 2022

HRR mutational status associated with survival outcomes in recurrent platinum-sensitive ovarian cancer

Results of a biomarker analysis of the NRG Oncology NRG-GY004 trial were presented at a Seminal Session during the Society for Gynecologic Oncology's (SGO) Annual Meeting on Women's Cancer in March 2022.

19 Mar 2022

Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

A combination therapy that targets cancer cells from within and without caused tumors to shrink or stabilize in 75% of patients with recurrent or persistent estrogen receptor- (ER-) positive endometrial cancer, results from a recent clinical trial show.

19 Mar 2022

University of Kentucky begins world’s first clinical trial for LATE

The motivation driving the work of Pete Nelson, M.D., Ph.D., is personal. His grandmother, Sylvia Becker, died with Alzheimer's disease, and he says his mother then grew terrified of developing the disease.

17 Mar 2022

New trial finds signs of preventive cardiovascular effects for cocoa flavanols

The first large-scale trial to test the long-term effects of a cocoa flavanol supplement to prevent cardiovascular disease offers promising signals that cocoa flavanols could have protective cardiovascular effects.

16 Mar 2022

New Phase 1 clinical trial of mRNA HIV vaccine enrolls first participant

The first 12 study participants have been enrolled in a new Phase 1 clinical trial using the messenger ribonucleic acid (mRNA) vaccine technology developed by Moderna.

14 Mar 2022

NIH launches Phase 1 clinical trial evaluating three experimental mRNA HIV vaccines

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched a Phase 1 clinical trial evaluating three experimental HIV vaccines based on a messenger RNA (mRNA) platform—a technology used in several approved COVID-19 vaccines.

14 Mar 2022

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer

A study led by researchers from The University of Texas MD Anderson Cancer Center showed a significant overall survival benefit with ribociclib plus endocrine therapy for postmenopausal patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer.

10 Mar 2022

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

10 Mar 2022

Single dose of new drug nirsevimab provides safe protection against RSV in healthy infants

The new drug nirsevimab showed 74.5 percent efficacy against medically attended lower respiratory tract infections caused by respiratory syncytial virus (RSV) in healthy infants, according to an international, randomized, placebo-controlled phase 3 clinical trial published in the New England Journal of Medicine.

9 Mar 2022

Clinical trial of novel rabies vaccine in human volunteers begins in Tanzania

The University of Oxford and the Ifakara Health Institute today announced the vaccination of the first participants in a Phase Ib/II trial testing a novel rabies vaccine in human volunteers in Tanzania.

9 Mar 2022

What does the Future Look Like for Patient Centricity within Clinical Trials?

In this interview, we speak to Dr. Paresh Malhotra about what the future holds for patient centricity within clinical trials, and the benefits for this focus.

7 Mar 2022

Combination treatment could benefit smokers who also drink heavily

One in five people who smoke also drink heavily, but they show worse outcomes than non-heavy drinkers in quitting smoking and are often excluded from smoking cessation trials.

4 Mar 2022

Long-acting monoclonal antibody shows potential to offer RSV protection for all infants

Nirsevimab showed 74.5 percent efficacy against medically attended lower respiratory tract infections caused by respiratory syncytial virus (RSV) in healthy infants, according to an international, randomized, placebo-controlled Phase 3 clinical trial.

3 Mar 2022

Assessing the potential of IFNa subtypes in suppressing SARS-CoV-2

A recent study analyzes IFNa subtypes for their therapeutic potential against SARS-CoV-2 and identified the underlying immune signatures and mechanisms.

3 Mar 2022

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced positive top-line results from the Phase 2 part of the Phase 2/3 study of once-daily oral RHB-107 (upamostat) in non-hospitalized symptomatic COVID-19 patients, predominantly conducted in the U.S. (60/61 patients) as well as South Africa.

1 Mar 2022

Researchers launch a multi-center trial to investigate new treatment for pediatric type 1 diabetes

Researchers at Massachusetts General Hospital, in partnership with NYU Langone Health, have launched a multi-center clinical trial to investigate a new treatment for pediatric type 1 diabetes even in subjects with established disease.

1 Mar 2022

Intensive treatment for patients with Crohn's disease found to be safe

Intensive treatment for patients with Crohn's disease showed no safety differences compared to the current standard of care, according to a trial published in the journal Gastroenterology.

1 Mar 2022

U of U Health researchers lead a $22-million nationwide clinical trial for rare brain disorder

University of Utah Health researchers are leading a five-year, $22-million nationwide clinical trial for NMDA receptor encephalitis––a type of autoimmune encephalitis that prompts the immune system to mistakenly attack the brain, causing confusion, memory loss, seizures, and symptoms similar to bipolar disorder and other psychiatric conditions.

1 Mar 2022

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Drug Trial News

Trial reveals effectiveness of axi-cel as first-line treatment for high-risk lymphoma

Trial shows safety and immunogenicity of immunotherapy with chemoradiation in cervical cancer patients

HRR mutational status associated with survival outcomes in recurrent platinum-sensitive ovarian cancer

Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

University of Kentucky begins world’s first clinical trial for LATE

New trial finds signs of preventive cardiovascular effects for cocoa flavanols

New Phase 1 clinical trial of mRNA HIV vaccine enrolls first participant

NIH launches Phase 1 clinical trial evaluating three experimental mRNA HIV vaccines

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

Single dose of new drug nirsevimab provides safe protection against RSV in healthy infants

Clinical trial of novel rabies vaccine in human volunteers begins in Tanzania

What does the Future Look Like for Patient Centricity within Clinical Trials?

Combination treatment could benefit smokers who also drink heavily

Long-acting monoclonal antibody shows potential to offer RSV protection for all infants

Assessing the potential of IFNa subtypes in suppressing SARS-CoV-2

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

Researchers launch a multi-center trial to investigate new treatment for pediatric type 1 diabetes

Intensive treatment for patients with Crohn's disease found to be safe

U of U Health researchers lead a $22-million nationwide clinical trial for rare brain disorder

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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