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Failures and findings from randomized clinical trials in COVID-19 convalescent plasma

Researchers complete an extensive search on previously published studies to understand the efficacy of convalescent plasma in treating COVID-19.

20 Sep 2021

Immunotherapy treatment may be appropriate for patients with earlier stages of melanoma

An immunotherapy called pembrolizumab reduced cancer recurrence after surgery in patients with stage IIb and IIc melanoma, according to the results of an international, randomized phase III clinical trial led by UPMC Hillman Cancer Center.

20 Sep 2021

A new synthetic multiantigen MVA vaccine COH04S1 effective against SARS-CoV-2

A new study utilized MVA to develop vaccine candidates that were subsequently evaluated in animal models of congenital cytomegalovirus disease.

19 Sep 2021

New data shows benefit of drug combination for metastatic castration resistant prostate cancer

New findings by researchers at Yale Cancer Center show the drug combination of nivolumab and rucaparib shows clinical activity for patients with chemotherapy-naïve, metastatic castration resistant prostate cancer (mCRPC).

18 Sep 2021

Novel drug combinations improve progression-free survival for patients with advanced NSCLC

New findings from a large study led by researchers at Yale Cancer Center shows the addition of the drugs oleclumab or monalizumab to durvalumab improved progression-free survival for patients with locally advanced non-small cell lung cancer (NSCLC).

18 Sep 2021

UW Medicine enrolls volunteers for COVID-19 booster vaccine trial

Researchers at the University of Washington School of Medicine are enrolling volunteers for a COVID-19 booster vaccine trial.

18 Sep 2021

Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

For the last seven years, researchers at the Lewis Katz School of Medicine at Temple University have been developing and refining CRISPR-based gene-editing technology for the treatment of human immunodeficiency virus type 1 (HIV) infection.

17 Sep 2021

Single dose of typhoid conjugate vaccine found to be safe and effective in Malawian kids

A new study, published today in the New England Journal of Medicine, finds a single dose of typhoid conjugate vaccine (TCV) – the only typhoid vaccine licensed for children as young as 6 months – is safe and 84 percent effective in protecting against typhoid in Blantyre, Malawi.

16 Sep 2021

Phase I trial investigates using antiparasitic nitazoxanide for treatment of COVID-19

In a recent study, researchers investigate the possibility of using the thiazolide antiparasitic nitazoxanide for the treatment of COVID-19.

15 Sep 2021

A review of mesenchymal stem cell therapy for severe COVID-19

Researchers find that MSC treatment is highly tolerated and effective in reducing lung damage in COVID-19 patients and improving their chances of recovery.

13 Sep 2021

Results from Phase 0/1 trial of ribociclib plus everolimus in patients with high-grade glioma announced

The Ivy Brain Tumor Center at Barrow Neurological Institute, the largest early-phase drug development program for brain cancer in the world, announced results from their Phase 0/1 clinical trial of ribociclib plus everolimus in patients with high-grade glioma (HGG).

13 Sep 2021

Scientists develop a novel and potent SARS-CoV-2 RBD-homodimer vaccine

A recent report published in the journal Cell Discovery has described the immunogenicity and protective efficacy of a novel coronavirus disease 2019 (COVID-19) subunit vaccine candidate. The vaccine induces robust immune responses in rodents and non-human primates and protects the animals against severe disease.

12 Sep 2021

Neoadjuvant CPA followed by surgical resection and maintenance atezolizumab meets safety criteria

Neoadjuvant cisplatin and pemetrexed plus atezolizumab followed by surgical resection and maintenance atezolizumab met safety criteria, according to research presented today in OA13: Topics in Pleural Mesothelioma at the IASLC 2021 World Conference on Lung Cancer.

12 Sep 2021

High-dose chemotherapy followed by immunotherapy benefits patients with acute myeloid leukemia

A clinical trial conducted at UNC Lineberger Comprehensive Cancer Center and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center found that high-dose cytarabine followed by subsequent immunotherapy treatment with pembrolizumab benefited patients with resistant or relapsed acute myeloid leukemia (AML), a highly aggressive cancer.

12 Sep 2021

Combination of chemotherapy and immune checkpoint inhibitors shows promise in NSCLC patients with untreated brain metastases

Treatment with atezolizumab plus carboplatin and pemetrexed was safe and yielded promising brain progression-free survival in patients with nonsquamous non-small cell lung cancer with untreated and asymptomatic brain metastases.

12 Sep 2021

New Columbia-Pfizer Clinical Trials Diversity Initiative aims to reduce health disparities

Columbia University Irving Medical Center, its Herbert Irving Comprehensive Cancer Center, and Pfizer Inc. have established the Columbia-Pfizer Clinical Trials Diversity Initiative, with the aim of reducing health disparities by increasing the participation of underrepresented minorities in clinical trials and enhancing the diversity of clinical researchers.

9 Sep 2021

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

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Drug Trial News

Failures and findings from randomized clinical trials in COVID-19 convalescent plasma

Immunotherapy treatment may be appropriate for patients with earlier stages of melanoma

A new synthetic multiantigen MVA vaccine COH04S1 effective against SARS-CoV-2

New data shows benefit of drug combination for metastatic castration resistant prostate cancer

Novel drug combinations improve progression-free survival for patients with advanced NSCLC

UW Medicine enrolls volunteers for COVID-19 booster vaccine trial

Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

Single dose of typhoid conjugate vaccine found to be safe and effective in Malawian kids

Phase I trial investigates using antiparasitic nitazoxanide for treatment of COVID-19

A review of mesenchymal stem cell therapy for severe COVID-19

Results from Phase 0/1 trial of ribociclib plus everolimus in patients with high-grade glioma announced

Scientists develop a novel and potent SARS-CoV-2 RBD-homodimer vaccine

Neoadjuvant CPA followed by surgical resection and maintenance atezolizumab meets safety criteria

High-dose chemotherapy followed by immunotherapy benefits patients with acute myeloid leukemia

Combination of chemotherapy and immune checkpoint inhibitors shows promise in NSCLC patients with untreated brain metastases

New Columbia-Pfizer Clinical Trials Diversity Initiative aims to reduce health disparities

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

Vesicular stomatitis virus-based COVID vaccines demonstrate potent antiviral efficacy against SARS-CoV-2 variants

HIV vaccine candidate trialed in Sub-Saharan Africa falls short

Trial tests effectiveness of two prospective stroke therapies over standard of care

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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