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Eli Lilly starts trial of treatment of mild to moderate Alzheimer's disease

Eli Lilly and Company has announced the start of a Phase III clinical trial studying LY450139, an investigational gamma secretase inhibitor for the treatment of mild to moderate Alzheimer's disease.

1 Apr 2008

Disappointing resuts for pimecrolimus, investigational anti-restenosis drug

A new medication that researchers had hoped would reduce the risk of arterial renarrowing after stenting has turned in a disappointing performance in a multicenter clinical trial, but the multi-reservoir stent that was used to deliver the drug is still considered promising.

1 Apr 2008

Diabetics have same risk for heart attack, stroke or death from cardiovascular diseases

People with diabetes have the same high risk for heart attack or stroke or cardiovascular death as people who've already had a heart attack, researchers reported in Circulation: Journal of the American Heart Association.

1 Apr 2008

Childhood leukemia survivors struggle with long-term comorbidities

Survival rates of childhood cancers, especially leukemia, have improved greatly in the past three decades, but survivors of this disease still seem to face many health and lifestyle challenges as young adults.

1 Apr 2008

Cerebral microbleeds more common than previously thought

New research shows cerebral microbleeds, which are lesions in the brain, are more common in people over 60 than previously thought.

1 Apr 2008

Significant reductions in mortality shown using blood pressure-lowering treatment in very elderly

Lowering the blood pressure of elderly patients could cut their total mortality by a fifth and their rate of cardiovascular events by a third, according to a new study presented at the American College of Cardiology in Chicago and published simultaneously in the New England Journal of Medicine.

1 Apr 2008

New blood pressure drug Micardis (Telmisartan) good at reducing deaths from heart attacks

An international team of researchers have found that a new blood pressure medication is as effective in reducing cardiovascular death, with fewer side effects than the current treatments offered.

1 Apr 2008

Hypertension treatment for the elderly cuts the risk of heart disease and stroke

New research from Britain suggests that when the elderly are treated for hypertension (high blood pressure) the medication reduces their risk of heart disease, stroke and even death.

1 Apr 2008

Fasting could offer protection from chemotherapy effects

A new study is suggesting that short-term fasting could help protect cancer patients against the effects of chemotherapy.

1 Apr 2008

Study shows Actos prevented progression of atherosclerotic plaque volume in patients

New data from a clinical trial using intravascular ultrasound (IVUS) technology found that in patients living with type 2 diabetes, ACTOS (pioglitazone HCl) reduced the atherosclerotic burden in the coronary arteries compared to glimepiride, and prevented progression compared to baseline.

1 Apr 2008

New blood pressure drug telmisartan has fewer side effects

A major Canadian-led global study has found that a new blood pressure medication is effective in reducing cardiovascular death, with fewer side effects than the current standard of care.

1 Apr 2008

Lebanese study looks at mental disorders and their relation to exposure to war

In the first study in the Arab world to document mental illness and treatment on a national level, researchers from Lebanon have described the prevalence of mental disorders and their relation to exposure to war.

1 Apr 2008

Matrix registry probes adherence to clopidogrel at 1 year

A large community-based registry of patients treated with drug-eluting stents is providing important insight into how long patients with complex coronary artery disease typically stick to their doctors' orders to take clopidogrel, a drug that prevents unwanted blood clots; why they stop taking the drug; and the long-term consequences of that decision.

1 Apr 2008

Fatality rates increase with repeal of helmet laws

Since 1975, more than 100,000 motorcycle riders in America have died in crashes.

1 Apr 2008

Study looks at use of powerful anticoagulants to prevent pulmonary embolism

Current US guidelines for the prescription of potent anticoagulants by surgeons who perform joint replacement operations could be doing patients more harm than good, according to Dr. Nigel Sharrock and his team from the Hospital for Special Surgery in New York.

1 Apr 2008

Angina drug ranolazine shows promise for heart rhythm disorders

A recently approved angina drug may also represent a powerful new treatment for a rare hereditary syndrome that places teens at risk for sudden cardiac death, according to research presented at the 57th Annual Scientific Sessions of the American College of Cardiology (ACC) in Chicago.

1 Apr 2008

Fasting for two days protects healthy cells against chemotherapy

The chemotherapy worked as intended on cancer, extending the lifespan of mice injected with aggressive human tumors, reported a group led by Valter Longo of the University of Southern California.

1 Apr 2008

Two drug combo blood pressure therapy lowers cardiovascular risk

An international blood pressure study comparing two single-pill drug combinations has yielded results so significant that the study has been stopped early and the researchers say their findings might alter the way high blood pressure is treated worldwide.

1 Apr 2008

New genetic clues to diabetes

An international team that included scientists from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today reported it has identified six more genetic variants involved in type 2 diabetes, boosting to 16 the total number of genetic risk factors associated with increased risk of the disease.

31 Mar 2008

Largest ever analysis of DES data demonstrates safety, efficacy in on-and-off-label use

The Cardiovascular Research Foundation (CRF) will present results of the largest meta-analysis to date comparing mortality rates for drug-eluting stents (DES) versus bare metal stents (BMS) at the Drug-Eluting Stent Revolution VII meeting tomorrow evening in Chicago.

31 Mar 2008