New cancer drug opportunities

NewsGuard 100/100 Score

An international study released this week in the prestigious journal Nature could revolutionise the way in which cancers are treated and potentially put an end to aggressive DNA damaging chemotherapies and radiotherapy treatments.

The study, entitled Single-strand DNA-binding protein hSSB1 is critical for genomic stability has identified and characterised a novel human single-stranded DNA binding protein (hSSB1). hSSB1 is an upstream sensor in the double-strand break response pathway - double strand DNA breaks are lethal if they are not repaired.

"Chemotherapy, which is highly toxic, is currently the only option for most cancer patients. Not only does chemotherapy kill off the cancerous cells, it also kills off healthy cells, leading to severe nausea, fatigue, hair loss and in some cases death," said co-author Dr Liza Cubeddu from the University of Sydney's School of Molecular and Microbial Biosciences.

hSSB1 is recruited to sites of DNA breaks where it co-localizes with other repair proteins. Cells depleted in hSSB1 are hypersensitive to ionizing radiation, which causes double-strand breaks that are not repaired efficiently.

"hSSB1 is a prerequisite for cancer cells to survive, normal cells can function without it," said Dr Cubeddu. "Developing a drug that can target the hSSB1 gene means that you can destroy cancerous cells while leaving healthy cells intact. This could revolutionise how cancers are treated and potentially put an end to aggressive DNA damaging chemotherapies and radiotherapy treatments," she said.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Plant-based diets reduce cancer and heart disease risks, study shows