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NIH clinical trial to test a combination treatment regimen for COVID-19

A clinical trial to test the safety, tolerability and efficacy of a combination treatment regimen for coronavirus disease 2019 (COVID-19) consisting of the antiviral remdesivir plus a highly concentrated solution of antibodies that neutralize SARS-CoV-2, the virus that causes COVID-19, has begun.

8 Oct 2020

FDA awards six clinical trial research grants to enhance development of therapies for rare diseases

Today, the U.S. Food and Drug Administration announced that it has awarded six new clinical trial research grants to principal investigators from academia and industry totaling over $16 million over the next four years.

8 Oct 2020

Experimental Chinese SARS-CoV-2 vaccine appears safe in early trials

A new study published on the preprint server medRxiv in October 2020 reports the findings of a phase I trial of an inactivated SARS-CoV-2 vaccine, demonstrating that it can elicit a potent immune response without significant adverse reactions.

7 Oct 2020

Multi-center Phase I study of anti-VISTA opens for patient enrollment

Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center will serve as one of the lead institutions for a new multi-center clinical trial of anti-VISTA, now open and recruiting for patient enrollment.

7 Oct 2020

CODA trial shows antibiotics may be a good choice for certain patients with appendicitis

Antibiotics may be a good choice for some, but not all, patients with appendicitis, according to results from the Comparing Outcomes of antibiotic Drugs and Appendectomy (CODA) Trial reported today in the New England Journal of Medicine.

6 Oct 2020

Antibiotic treatment is as good as appendectomy for a majority of adults with appendicitis

Seven of 10 adults with appendicitis can safely avoid surgical removal of their appendix (appendectomy) for at least several months by receiving a course of antibiotics, according to early results of a U.S. study that is the largest to compare use of these drugs alone versus an operation for appendicitis treatment.

6 Oct 2020

Eli Lilly's LY-CoV555 antibody shows potential as COVID-19 treatment

Researchers in the United States and Canada have discovered a monoclonal antibody that potently neutralizes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

5 Oct 2020

Two phase II clinical trials suggest potential new treatment options for metastatic cervical cancer

Preliminary results from two independent, phase II clinical trials investigating a new PD-1 (programmed cell death protein 1)-based immune therapy for metastatic cervical cancer suggest potential new treatment options for a disease that currently has limited effective options and disproportionately impacts younger women.

5 Oct 2020

Trial examines prehospital administration of blood-clotting agent in severely injured trauma patients

Severely injured trauma patients who received a blood-clotting drug before arriving at the hospital had a better chance of surviving than those who didn't, according to new research from the University of Pittsburgh School of Medicine.

5 Oct 2020

Investigational mRNA vaccine to prevent SARS-CoV-2 shows promise in older adults

A Phase 1 trial of an investigational mRNA vaccine to prevent SARS-CoV-2 infection has shown that the vaccine is well-tolerated and generates a strong immune response in older adults.

30 Sep 2020

New trial to evaluate anti-TNF drug as a treatment for COVID-19 patients begins

Researchers at the University of Oxford are starting a new study to explore the effectiveness of the anti-tumour necrosis factor (anti-TNF) drug adalimumab as a treatment for patients with COVID-19 in the community, especially care homes.

30 Sep 2020

Australian scientists develop a nasal spray that could stop SARS-CoV-2 infection

The novel product, called INNA-051, is being developed by Ena Respiratory, and laboratory experiments have shown that it reduced viral replication by as much as 96 percent in the animal study. Spearheaded by Public Health England’s (PHE) Deputy Director, Professor Miles Carroll, the new study described the potential treatment and has been published in the open-source preprint server bioRxiv*.

29 Sep 2020

Dartmouth TB vaccine moves one step closer to a full Phase 3 efficacy trial

Results from the Phase 2 trial of the DAR-901 tuberculosis (TB) vaccine were announced today by investigators at Dartmouth's Geisel School of Medicine and published in the journal Vaccine.

29 Sep 2020

Phase 1 trial of new class of drugs shows promise in range of advanced cancers

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial - highlighting the potential of a new class of drugs known as ATR inhibitors.

29 Sep 2020

J&J's COVID-19 vaccine shows potent immune response in phase 2 human trial

A multicenter phase 1/2a randomized, double-blinded, placebo-controlled clinical trial has been conducted recently to evaluate the safety, reactogenicity, and immunogenicity of a non-replicating adenovirus-based vaccine, namely Ad26.COV2.S against severe acute respiratory coronavirus 2 (SARS-CoV-2) infection.

28 Sep 2020

Targeted therapy found to be effective at shrinking tumors in patients with nonsmall-cell lung cancer

An international team of researchers has found that selpercatinib, a drug that precisely targets cancers driven by mutations or alterations in the gene RET, was effective at shrinking tumours in patients with nonsmall cell lung cancer (NSCLC), with a majority of patients living for more than a year without disease progression.

28 Sep 2020

Study reveals underrepresentation of older people in COVID-19 trials

A study published today in the Journal of the American Medical Association Internal Medicine revealed that older persons are highly likely to be excluded from the majority of COVID-19 trials that seek to establish effective treatments, as well as find a preventive vaccine.

28 Sep 2020

Clover Biopharma's new trimeric subunit vaccine candidate prevents COVID-19 in monkeys

The vaccine candidate produced a high level of neutralizing antibodies in animal models. Rhesus macaques immunized with the vaccine candidate showed reduced viral loads in the lungs. The research is published on the preprint server bioRxiv.

28 Sep 2020

Special formulation of inhaled niclosamide may be effective against SARS-CoV-2

Now in new research published on the preprint server bioRxix*, a novel formulation of the drug Niclosamide (NIC) is observed to be effective against SARS-CoV-2 and MERS-CoV in mouse models; it also protects against methicillin-resistance Staphylococcus aureus pneumonia and inflammatory lung damage.

28 Sep 2020

New drug offers hope for young boys with Duchenne muscular dystrophy

A new drug offers hope for young boys with the progressive neuromuscular disease Duchenne muscular dystrophy (DMD) by potentially offering an alternative to high-dose glucocorticoids that have significant side effects.

25 Sep 2020

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Drug Trial News

NIH clinical trial to test a combination treatment regimen for COVID-19

FDA awards six clinical trial research grants to enhance development of therapies for rare diseases

Experimental Chinese SARS-CoV-2 vaccine appears safe in early trials

Multi-center Phase I study of anti-VISTA opens for patient enrollment

CODA trial shows antibiotics may be a good choice for certain patients with appendicitis

Antibiotic treatment is as good as appendectomy for a majority of adults with appendicitis

Eli Lilly's LY-CoV555 antibody shows potential as COVID-19 treatment

Two phase II clinical trials suggest potential new treatment options for metastatic cervical cancer

Trial examines prehospital administration of blood-clotting agent in severely injured trauma patients

Investigational mRNA vaccine to prevent SARS-CoV-2 shows promise in older adults

New trial to evaluate anti-TNF drug as a treatment for COVID-19 patients begins

Australian scientists develop a nasal spray that could stop SARS-CoV-2 infection

Dartmouth TB vaccine moves one step closer to a full Phase 3 efficacy trial

Phase 1 trial of new class of drugs shows promise in range of advanced cancers

J&J's COVID-19 vaccine shows potent immune response in phase 2 human trial

Targeted therapy found to be effective at shrinking tumors in patients with nonsmall-cell lung cancer

Study reveals underrepresentation of older people in COVID-19 trials

Clover Biopharma's new trimeric subunit vaccine candidate prevents COVID-19 in monkeys

Special formulation of inhaled niclosamide may be effective against SARS-CoV-2

New drug offers hope for young boys with Duchenne muscular dystrophy

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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