Genomics

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Genetic cause of lupus identified

An international team of researchers has identified DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments.

27 Apr 2022

Gut virome may warn of a serious and often fatal disease in preterm infants

Immediately after birth, human infants begin to develop a complex, interwoven fabric of microbes in their gut.

26 Apr 2022

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

Age-related changes in strength and mobility may depend on genetic variations in a critical mitochondrial enzyme, suggests a study published today in eLife.

26 Apr 2022

Researchers develop new platform capable of mitochondrial DNA editing

Researchers from the Center for Genome Engineering within the Institute for Basic Science developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED.

25 Apr 2022

DNA analysis of tumors uncovers a 'treasure trove' of clues about the causes of cancer

DNA analysis of thousands of tumors from NHS patients has found a 'treasure trove' of clues about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.

21 Apr 2022

Researchers discover more needles in the haystack in the quest to unravel Alzheimer’s disease

21 million. That's the number of genetic variations in the human genome that researchers are sifting to identify patterns predisposing people to Alzheimer's disease.

20 Apr 2022

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Alzheimer's disease is marked by a loss of functional neurons in the brain. But what causes this loss? Through single-cell genome sequencing, researchers at Boston Children's Hospital, Brigham and Women's Hospital, and the Broad Institute show that people with Alzheimer's have an abundance of newly acquired mutations in their neurons - more than people of the same age without Alzheimer's, and enough to disable genes important to brain function.

20 Apr 2022

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Small genetic differences can affect the ability to utilize energy of various nutrients, study finds

Carbohydrates, proteins and fats are essential nutrients to all animals. Yet dietary variation between species, populations and individuals can vary dramatically.

19 Apr 2022

Researchers develop and validate polygenic risk scores for six common diseases

A person's risk of developing diseases such as type 2 diabetes or breast cancer may be influenced by thousands of genetic differences.

18 Apr 2022

Research shines light on the effects of genomic variation on gut microbiome function

New research from Cornell scientists is exploring how human genetics impacts functions of the gut microbiome, and is expanding awareness of the role human genetics plays in shaping the microbiome.

18 Apr 2022

Two strains of TB bacterium attack the lungs in completely different fashion, study finds

Two strains of the bacterium causing tuberculosis have only minor genetic differences but attack the lungs in completely different fashion, according to Rutgers researchers.

18 Apr 2022

RNA interference triggers that target SARS-CoV-2 genome

Researchers screened ribonucleic acid interference against SARS-CoV-2.

18 Apr 2022

Manipulating a specific gene from yeast could lead a new approach to combatting drug resistance

A recent study that shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance when treating microbial infections or cancer.

18 Apr 2022

Yale research demonstrates the cancer relevance of known human genes

Following an analysis of over 12,000 human genes, research from Yale Cancer Center indicates there is cancer-relevant importance in a much larger proportion of human genes than current cancer research models suggest.

14 Apr 2022

Bioprinting for bone repair enhanced with two growth factor encoding genes

Given enough time and energy, the body will heal, but when doctors or engineers intervene, the processes do not always proceed as planned because chemicals that control and facilitate the healing process are missing.

13 Apr 2022

Researchers construct first single-cell atlas of postnatal lung development in humans and mice

How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? To help answer these questions, scientists have constructed the first single-cell atlas of postnatal lung development in humans and mice.

12 Apr 2022

Genomics

Genetic cause of lupus identified

Gut virome may warn of a serious and often fatal disease in preterm infants

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

Researchers develop new platform capable of mitochondrial DNA editing

DNA analysis of tumors uncovers a 'treasure trove' of clues about the causes of cancer

Researchers discover more needles in the haystack in the quest to unravel Alzheimer’s disease

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

Small genetic differences can affect the ability to utilize energy of various nutrients, study finds

Researchers develop and validate polygenic risk scores for six common diseases

Research shines light on the effects of genomic variation on gut microbiome function

Two strains of TB bacterium attack the lungs in completely different fashion, study finds

RNA interference triggers that target SARS-CoV-2 genome

Manipulating a specific gene from yeast could lead a new approach to combatting drug resistance

Yale research demonstrates the cancer relevance of known human genes

Bioprinting for bone repair enhanced with two growth factor encoding genes

Researchers construct first single-cell atlas of postnatal lung development in humans and mice

Vaccine-induced blood clots may be the result of genetics, study finds

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

MOFs could help improve the delivery of genetic cargo into target cells

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

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