Genomics

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BGI discovery could pave the way for advances in organ regeneration and synthetic biology

In a world-first, scientists from BGI-Research, Chinese Academy of Sciences, and a group of partners published a study in Nature, announcing the discovery of a transgene-free, rapid, and controllable method to convert pluripotent stem-cells into bona fide 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology.

22 Mar 2022

Scientists find striking lane-like patterns in bacteria populations

It's well understood that populations of species don't distribute at random. Rather, as populations grow, individuals are organized around barriers in the landscape

22 Mar 2022

Experts highlight understated ethics, unclear utility of polygenic embryo testing

New technologies are expanding the reach and accessibility of preimplantation genetic testing of human embryos. But what these advances can deliver is still unclear, and a frank assessment of their profound ethical implications is urgently needed, concludes a commentary in Nature Medicine.

22 Mar 2022

New insight into genetic mechanisms that control appetite and energy metabolism early in life

Have you ever wondered why it is so different how quickly and how much small babies put on weight during the first years of life? Now researchers at the University of Bergen in Norway have found that this is largely controlled by our genes.

21 Mar 2022

Multiple inter-variant recombination events identified in Omicron subvariants

Newly emerging and circulating Omicron subvariants have originated partially through recombination with other variants.

20 Mar 2022

Cov2clusters: Novel method for producing stable genomic clusters of SARS-CoV-2 cases

Researchers present a novel method for producing stable genomic clustering of SARS-CoV-2 cases, Cov2clusters.

20 Mar 2022

Omicron BA.1.1 and BA.2 subvariants with new mutations in New Zealand and Hong Kong

A new study describes mutations found in the SARS-CoV-2 BA.1 variant in Hong Kong and New Zealand.

20 Mar 2022

A single gene can control brain cell growth in humans, research shows

Controlling how cells grow is fundamental to ensuring proper brain development and stopping aggressive brain tumors.

19 Mar 2022

A complete transcriptomic analysis of astrocytes in Alzheimer's disease

An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer's patients and in people without diagnosed dementia.

18 Mar 2022

New virus-based approach for measuring variations in gene regulatory elements

Tohoku University scientists in Japan have developed a virus-based approach for measuring variations in gene regulatory elements, called transcription factors, as conditions change in live organisms.

18 Mar 2022

Research demonstrates within-host seasonal immunity

Researchers investigate the association between seasonal flu changes and gene expression to determine the ‘within-host’ immunity concept.

17 Mar 2022

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off altogether.

17 Mar 2022

Mayo Clinic researchers report differences in genomic data quality among racial groups

Mayo Clinic researchers studied the differences in genomic data quality among racial groups in one of the largest and most widely used cancer research datasets, The Cancer Genome Atlas.

17 Mar 2022

Researchers identify a gene that could prevent Parkinson’s disease

Parkinson's disease is a neurodegenerative disorder characterized by the destruction of a specific population of neurons: the dopaminergic neurons.

17 Mar 2022

Tracking the mutating coronavirus variants

Viruses continuously and naturally evolve. To track coronavirus variants, we need to think like Darwin.

16 Mar 2022

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term.

16 Mar 2022

Study takes a new approach to looking at de novo genetic variants in autism

About 1 in 44 children in the U.S. are diagnosed with autism spectrum disorder (ASD) by the age of 8, according to the 2018 Centers for Disease Control and Prevention surveillance. How a child's DNA contributes to the development of ASD has been more of a mystery.

15 Mar 2022

First genetic rat model of Down syndrome offers better understanding of the condition

In pursuit of better ways to test new therapies and further explore the impacts of the unique genetics associated with Down syndrome, researchers at Johns Hopkins Medicine and Tottori University in Japan have genetically engineered and characterized what is believed to be the first rat model of Down syndrome.

14 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

UCI researchers reveal new details about a key enzyme that makes DNA sequencing possible

In a paper published today in Sciences Advances, researchers in the Department of Chemistry and the Department of Physics & Astronomy at the University of California, Irvine revealed new details about a key enzyme that makes DNA sequencing possible.

12 Mar 2022

Genomics

BGI discovery could pave the way for advances in organ regeneration and synthetic biology

Scientists find striking lane-like patterns in bacteria populations

Experts highlight understated ethics, unclear utility of polygenic embryo testing

New insight into genetic mechanisms that control appetite and energy metabolism early in life

Multiple inter-variant recombination events identified in Omicron subvariants

Cov2clusters: Novel method for producing stable genomic clusters of SARS-CoV-2 cases

Omicron BA.1.1 and BA.2 subvariants with new mutations in New Zealand and Hong Kong

A single gene can control brain cell growth in humans, research shows

A complete transcriptomic analysis of astrocytes in Alzheimer's disease

New virus-based approach for measuring variations in gene regulatory elements

Research demonstrates within-host seasonal immunity

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Mayo Clinic researchers report differences in genomic data quality among racial groups

Researchers identify a gene that could prevent Parkinson’s disease

Tracking the mutating coronavirus variants

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Study takes a new approach to looking at de novo genetic variants in autism

First genetic rat model of Down syndrome offers better understanding of the condition

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

UCI researchers reveal new details about a key enzyme that makes DNA sequencing possible

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

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