Genomics

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Thermo Fisher Scientific to accelerate genomic profiling process in hematology and oncology labs

Clinical researchers who take a traditional sequential approach to analyze myeloid malignancies, a highly heterogeneous group of disorders, face a major hurdle: a laborious and time-consuming workflow.

From Thermo Fisher Scientific Inc. 9 Dec 2019

New tool can rapidly reveal unintended changes made by CRISPR-directed gene editing

Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a new study in the Nature journal Communications Biology describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process.

6 Dec 2019

Baylor researchers report creation of an 'epigenetic couch potato' mouse

Why is it that some people love to exercise, and others hate it? Most people would assume it's all due to genetics, but a new Baylor College of Medicine led study in mice shows for the first time that a different molecular level of regulation - epigenetics - plays a key role in determining one's innate drive to exercise.

4 Dec 2019

China raises ethical concern by recreating faces using DNA samples

Researchers in China are reportedly using blood samples taken from minority groups in an attempt to reconstruct faces from DNA.

4 Dec 2019

Using genomics to identify promising novel treatment for lymphatic filariasis

Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine Institute for Genome Sciences identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat.

3 Dec 2019

Unexpected versatility of an ancient DNA repair factor revealed

If a bone breaks or a tendon snaps, you know to seek treatment immediately. But your most fragile and precious cellular commodity, chromosomal DNA, breaks with astounding frequency- some estimate as many as 10,000 times a day per cell- usually without consequence.

2 Dec 2019

Link found between the gut microbiome, host genome, and RA in Japanese population

One of the most astounding discoveries of recent times is just how much influence gut bacteria have on our health and well-being.

2 Dec 2019

Scientists discover new principle for activation of cancer genes

Researchers have long known that some genes can cause cancer when overactive, but exactly what happens inside the cell nucleus when the cancer grows has so far remained enigmatic.

2 Dec 2019

Gene discovery in fruit flies could provide clues to counteract mitochondrial diseases

Scientists have identified a protein in fruit flies that can be targeted to reverse the effects of disease-causing mutations in mitochondrial genes. The discovery could provide clues about how to counteract human mitochondrial diseases, for which there is currently no cure.

28 Nov 2019

Potential new treatment for mitochondrial diseases discovered from fruit fly genes

Researchers have discovered a way to reverse the impact of disease-causing mitochondrial mutations by targeting fruit fly gene.

27 Nov 2019

Hibernators reveal genetic clues to better understand and treat obesity, metabolic disorders

Hibernation is one of nature's strangest quirks, inducing bears and other mammals to pack on massive weight- amounts that would be unhealthy for humans-;so they can survive months of slumber. Yet when these animals reemerge, they are as fit as ever.

27 Nov 2019

The success of clownfish families linked to high-quality habitats, not shared genes

In a study published today, scientists report that the long-term success of clownfish depends more on living in a good neighborhood than it does on good genes.

26 Nov 2019

New highly sensitive test for dengue virus developed using DNA star

Researchers have developed a new method for detecting and destroying the dengue virus that could be adapted for other viruses.

25 Nov 2019

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

One of the ways a cancer-causing gene works up enough power to turn a normal cell into a cancer cell is by copying itself over and over, like a Xerox machine.

21 Nov 2019

Circular DNA found in cancer cells supports their survival and resistance

A new study uncovers the role of the circular, 3D shape of extrachromosomal DNA in augmenting mutant oncogenes in cancer cells.

20 Nov 2019

Mining 'darkest' parts of the genome in cancer cells yields gold

Mining the rich uncharted territory of the genome or genetic material of a cancer cell has yielded gold for Princess Margaret scientists: new protein targets for drug development against prostate cancer.

15 Nov 2019

Leukemia type B cell can transform into a macrophage through epigenetic changes

All the tissues of our body have the same DNA, but they perform very different functions and have very different aspects.

13 Nov 2019

DNA data provides scientific knowledge on historical extra-pair paternity in Western Europe

These days it's easy to resolve questions about paternity with over-the-counter test kits. Now, researchers have put DNA evidence together with long-term genealogical data to explore similar questions of biological fatherhood on a broad scale among people living in parts of Western Europe over the last 500 years.

11 Nov 2019

Scientists discover origins of world’s deadliest strain of cereal rust disease

Scientists have uncovered the origins of the world’s deadliest strain of cereal rust disease which threatens global food security.

11 Nov 2019

Understanding Monoclonal Antibody Unfolding and Aggregation

A therapeutic monoclonal antibody and its Fab and Fc fragments were recently investigated using differential scanning fluorimetry, temperature-ramped dynamic light scattering, and turbidity measurements.

From Waters | Wyatt Technology 8 Nov 2019

Genomics

Thermo Fisher Scientific to accelerate genomic profiling process in hematology and oncology labs

New tool can rapidly reveal unintended changes made by CRISPR-directed gene editing

Baylor researchers report creation of an 'epigenetic couch potato' mouse

China raises ethical concern by recreating faces using DNA samples

Using genomics to identify promising novel treatment for lymphatic filariasis

Unexpected versatility of an ancient DNA repair factor revealed

Link found between the gut microbiome, host genome, and RA in Japanese population

Scientists discover new principle for activation of cancer genes

Gene discovery in fruit flies could provide clues to counteract mitochondrial diseases

Potential new treatment for mitochondrial diseases discovered from fruit fly genes

Hibernators reveal genetic clues to better understand and treat obesity, metabolic disorders

The success of clownfish families linked to high-quality habitats, not shared genes

New highly sensitive test for dengue virus developed using DNA star

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

Circular DNA found in cancer cells supports their survival and resistance

Mining 'darkest' parts of the genome in cancer cells yields gold

Leukemia type B cell can transform into a macrophage through epigenetic changes

DNA data provides scientific knowledge on historical extra-pair paternity in Western Europe

Scientists discover origins of world’s deadliest strain of cereal rust disease

Understanding Monoclonal Antibody Unfolding and Aggregation

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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