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Key proteins and pathways drive the success of CAR-T cell therapy

A study conducted by researchers at the Center for Cell-Based Therapy (CTC) highlights key proteins and signaling pathways involved in the efficacy of immunotherapy based on CAR-T cells (lymphocytes modified in the laboratory to fight cancer).

4 Jun 2025

PCSK9 protein controls how pancreatic cancer cells spread to the lung or liver

A protein called PCSK9 determines how pancreatic cancer cells metastasize to different parts of the body.

4 Jun 2025

Two patients faced chemo. The one who survived demanded a test to see if it was safe.

JoEllen Zembruski-Ruple, while in the care of New York City's renowned Memorial Sloan Kettering Cancer Center, swallowed the first three chemotherapy pills to treat her squamous cell carcinoma on Jan. 29, her family members said. They didn't realize the drug could kill her.

4 Jun 2025

SWOG S2302 Pragmatica-Lung study demonstrates value of streamlined clinical trials in real world settings

The SWOG S2302 Pragmatica-Lung trial, which broke new ground with its streamlined pragmatic design, unusually broad eligibility criteria, and reduced data collection, has quickly answered its primary question, finding that the investigational combination it tested did not significantly extend overall survival compared to standard of care treatments.

4 Jun 2025

Does lithium offer hope for long COVID brain fog and fatigue? New trial gives mixed results

A randomized clinical trial found that low-dose lithium aspartate did not improve cognitive dysfunction or fatigue in long COVID patients. Higher doses showed possible benefits in a small exploratory substudy, but larger trials are needed.

4 Jun 2025

ADHD linked to higher risk of irritable bowel syndrome, global study reveals

A global meta-analysis found that people with ADHD are significantly more likely to have irritable bowel syndrome (IBS), while the overall risk for other intestinal disorders is not increased. The findings highlight the importance of gut-brain interactions in ADHD and call for further research on microbiome-based therapies.

3 Jun 2025

AI spots future breast cancer risk in mammograms years before diagnosis

In a large Norwegian study, a commercial AI tool analyzed routine mammograms and identified women at elevated risk of developing breast cancer up to 4–6 years before diagnosis. These AI-generated risk scores may help personalize breast cancer screening and facilitate earlier interventions.

3 Jun 2025

Navigating the dual role of B cells in tumor immunity

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

3 Jun 2025

Early camizestrant therapy keeps advanced breast cancer in check

Switching to camizestrant, a next-generation oral SERD, significantly prolongs progression-free survival and maintains quality of life in patients with ESR1-mutated, hormone receptor-positive advanced breast cancer. The proactive, biomarker-guided approach allows earlier intervention and may redefine standard care.

3 Jun 2025

Whole-class mental health sessions in schools help reduce depression and anxiety

Whole-class mental health sessions in schools have a small but significant effect in reducing depression and anxiety symptoms, according to new analysis led by researchers at UCL (University College London) and Anna Freud.

3 Jun 2025

UC Irvine researchers uncover altered RNA processing in ALS

UC Irvine researchers conducted a study to better understand the molecular basis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder in which patients lose the ability to move, becoming weak and wheelchair bound before dying because they can no longer breathe.

3 Jun 2025

Exercise after chemo key for colon cancer survival, study finds

Post-chemotherapy exercise significantly boosts disease-free survival in colon cancer patients, underscoring the importance of structured physical activity.

3 Jun 2025

Plant-based portfolio diet linked to fewer heart-related deaths

The portfolio diet significantly lowers heart disease risk, with long-term benefits for cardiovascular health and all-cause mortality in diverse populations.

3 Jun 2025

Japanese study shows c-sections do not raise allergy risk in children

A Japanese study reveals cesarean births do not increase childhood allergy risk, contradicting earlier findings and highlighting the need for further research.

3 Jun 2025

Daily bean consumption linked to improved heart and metabolic health

A new study suggests that regularly eating a cup of beans a day may offer measurable benefits for heart and metabolic health.

3 Jun 2025

Carotid plaques may quietly become more dangerous over time

Using data from the Rotterdam Study in the Netherlands, researchers have uncovered that carotid artery plaques can undergo potentially dangerous changes over time in patients without symptoms, according to a study was published today in Radiology, a journal of the Radiological Society of North America.

3 Jun 2025