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New approach to tackling chronic inflammatory diseases

An EU-funded project has developed new approaches to tackling chronic inflammatory diseases. These will be used to create precise and individualized treatment options, potentially leading to faster diagnosis, more effective treatments and even cures.

1 Mar 2019

New tool uncovers molecular causes of different diseases

Princeton University researchers are gaining new insights into the causes and characteristics of diseases by harnessing machine learning to analyze molecular patterns across hundreds of diseases simultaneously.

1 Mar 2019

New multi-year affiliation announced to establish global center for rare diseases

The University of Oxford and University Hospitals in Cleveland, Ohio, today announced a multi-year affiliation to establish a global center for rare diseases.

1 Mar 2019

Johns Hopkins study sheds light on resistance to radiation treatment

A new Johns Hopkins study offers promise towards someday being able to non-invasively examine changes in cancerous tumors to determine whether they'll respond to radiation treatment, before treatment even begins.

1 Mar 2019

CHLA awarded $1.36 million grant to adapt patient-driven model of diabetes care

Children's Hospital Los Angeles has been awarded a $1.36M grant from The Leona M. and Harry B. Helmsley Charitable Trust to adapt a patient-driven model of care that Clinical Diabetes Director, Jennifer Raymond, MD, MCR, developed to increase treatment compliance among difficult to reach populations.

1 Mar 2019

Lipid-filled particle plays role in immune function and metabolism

Researchers have discovered that fat tissue releases a lipid-filled particle that has a role in immune function and metabolism. The study, in mice, was published online in the journal Science.

1 Mar 2019

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines.

1 Mar 2019

Engineer to develop drug-filled hydrogel to repair the damaged heart

After a heart attack, the cells in the heart muscle cannot get enough nutrients and oxygen to survive, so they die. A structural support network in the heart's wall can help those cells regenerate, however, two enzymes that break down the network are naturally increased after a heart attack, leaving the heart in a fight for its life.

28 Feb 2019

Protein content of tumors correlates with treatment response and survival in glioma patients

Brain tumors vary widely in how they respond to treatment. However, early assessment of therapy response is essential in order to choose the best possible treatment for the patient.

28 Feb 2019

Research reveals how metabolites can be used to inhibit epigenetic mechanisms and treat MS

Understanding and mitigating the role of epigenetics (environmental influences that trigger changes in gene expression) in disease development is a major goal of researchers.

28 Feb 2019

Pesticides, other environmental pollutants advance progression of ALS

While exact causes of amyotrophic lateral sclerosis (ALS) remain unknown, new research shows pesticides and other environmental pollutants advance the progression of the neurodegenerative disease.

28 Feb 2019

Prenatal vitamins may reduce the risk of autism in high-risk families

Researchers have found that mothers of children with autism may be able to reduce the risk of autism in further offspring by taking prenatal vitamins.

28 Feb 2019

Researchers reveal promising biomarker for vascular disease relapse

Researchers at Okayama University report in the journal Arthritis & Rheumatology that monitoring a particular antigen can be used for predicting relapse of the vascular disease AAV.

28 Feb 2019

Infants born with heart defects more likely to develop heart problems later in life

An infant born with a relatively simple heart defect is far more likely to develop heart problems as an adult, researchers at the Stanford University School of Medicine have discovered.

28 Feb 2019

Listening to older patients who want to stop dialysis

Dr. Susan Wong sat down with an 84-year-old patient in the hospital, where he'd been admitted with a flare-up of a serious autoimmune condition and deteriorating kidney function.

28 Feb 2019

Study elucidates mechanism behind development of steroid diabetes

Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout the body, how these adverse effects are caused and by which organ are not well understood.

28 Feb 2019

Personalized therapy for aggressive brain cancer shows potential

Advances in genetics and genomics have taught us that every single tumor is different, and yet most standard therapies treat them all in the same way, limiting the effectiveness of treatments offered to many cancer patients.

28 Feb 2019

Researchers are developing and testing novel gene therapy to cure Crigler-Najjar syndrome

Crigler-Najjar syndrome affects about one in a million people at birth. Because of a defective gene, these individuals lack an essential enzyme in their liver to eliminate bilirubin, a toxic bile pigment that accumulates in all body tissues causing jaundice and potentially leading to irreversible and lethal neurological damage.

28 Feb 2019

Johns Hopkins researchers find genetic cause of olfactory neuroblastoma

By sequencing the entire genomes of tumor cells from six people with a rare cancer of the nose and sinus cavity, Johns Hopkins researchers report they unexpectedly found the same genetic change¾one in a gene involved in muscle formation¾in five of the tumors.

28 Feb 2019

Newly discovered drug targets could pave way for esophageal cancer therapeutics

Blocking two molecular pathways that send signals inside cancer cells could stave off esophageal adenocarcinoma, the most common esophageal malignancy in the United States, according to new research out of Case Western Reserve University School of Medicine.

28 Feb 2019