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OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

OHSU scientists have discovered a naturally occurring disease in monkeys that mimics a deadly childhood neurodegenerative disorder in people - a finding that holds promise for developing new gene therapies to treat Batten disease.

27 Jul 2018

Genetic factors may play a role in progression of liver injury in Caucasians with hepatitis B infection

A new study has shown that genetic variation may increase the risk of severe liver damage in Caucasians with chronic hepatitis B infection.

27 Jul 2018

Portfolio diet reduces risk factors for cardiovascular disease

University of Toronto researchers have found that the portfolio diet, a plant-based way of eating previously shown to lower cholesterol levels, reduces other risk factors for cardiovascular disease including blood pressure, triglycerides and inflammation.

27 Jul 2018

Diet-induced obesity synchronizes opposing liver fat metabolic processes in mice

Mice fed a fattening diet develop new liver circadian rhythms that impact the way fat is accumulated and simultaneously burned, according to a new study published in Cell by researchers in the Perelman School of Medicine at the University of Pennsylvania.

27 Jul 2018

Cannabis appears to have no effect on breathlessness during exercise in advanced COPD patients

Inhaled vaporized cannabis does not appear to improve or worsen exercise performance and activity-related breathlessness in patients with advanced chronic obstructive pulmonary disease, according to a randomized controlled trial published online in the Annals of the American Thoracic Society.

27 Jul 2018

Researchers investigate how nephrologists should discuss treatment options with older patients

Kidney specialists differ in their approaches to treatment decision-making with older patients with kidney failure, with many nephrologists not describing conservative management and some limiting patients' role in decision-making, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology

27 Jul 2018

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Novartis today announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion recommending approval of Tafinlar® in combination with Mekinist® for the adjuvant treatment of adult patients with stage III melanoma with a BRAF V600 mutation, following complete resection.

27 Jul 2018

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that the Committee for Medicinal Products for Human Use has adopted a Positive Opinion recommending marketing authorization of patisiran for the treatment of hereditary transthyretin-mediated amyloidosis in adults with stage 1 or stage 2 polyneuropathy.

27 Jul 2018

Therapy with L-Glutamine reduces pain in patients with sickle cell disease

UCSF Benioff Children's Hospital Oakland clinical researchers, in conjunction with other sickle cell centers and scientists at Emmaus Life Sciences, Inc., have demonstrated that therapy with L-Glutamine reduced the frequency of pain episodes in both pediatric and adult patients with sickle cell disease.

27 Jul 2018

Targeting mossy cells may offer new strategy for treating brain disorders

A small population of brain cells deep in a memory-making region of the brain controls the production of new neurons and may have a role in common brain disorders, according to a study from scientists at the University of North Carolina School of Medicine.

27 Jul 2018

Newer version of ALS drug may effectively treat inherited form of the disease

NIH-funded researchers delayed signs of amyotrophic lateral sclerosis in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1.

27 Jul 2018

Brain scan can help select the right Parkinson’s patients for clinical trials

From today forward, researchers and drug companies have a new tool in the search for better treatments for Parkinson’s – a brain scan that can be used to select the right people for clinical trials.

27 Jul 2018

DePuy Synthes introduces new CONCORDE LIFT Implant to treat patients with degenerative disc disease

Johnson & Johnson Medical Devices Companies today announced that DePuy Synthes is launching the CONCORDE LIFT Expandable Interbody Device in the U.S.

From DePuy Synthes 27 Jul 2018

Bile acids from the gut may offer new treatment for cocaine abuse

Bile acids that aid fat digestion are also found to reduce the rewarding properties of cocaine use, according to a study publishing on July 26 in the open-access journal PLOS Biology by India Reddy, Nicholas Smith, and Robb Flynn of Vanderbilt University, Aurelio Galli of the University of Alabama at Birmingham, and colleagues.

27 Jul 2018

Qualification of first Parkinson's biomarker represents major milestone in clinical trials

The biomarker is used to determine the presence of dopamine transport deficiency in the brain, and has been qualified as an enrichment biomarker for clinical trials targeting early stages of Parkinson's, soon after diagnosis

27 Jul 2018

Researchers discover new protein that controls level of inflammation-inducing molecule

One of the major therapeutic targets for inflammatory diseases is the inflammation-inducing molecule TNF. However, excess levels of TNF cause side effects and can lead to diseases.

27 Jul 2018

Scientists take important step to understand mechanisms that cause Huntington's disease

The neuroscientist Dr David Vilchez and his team at CECAD, the University of Cologne's Cluster of Excellence for Aging Research, have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease.

27 Jul 2018

Researchers develop nano-carriers to specifically target senescent cells

Senescent cells are damaged cells that do not perform their normal roles anymore but that are not dead -hence they are commonly known as zombi cells.

27 Jul 2018

Brain's response to taste stimuli could play role in driving anorexia nervosa

Researchers at the University of Colorado Anschutz Medical Campus have found that the brain's response to taste stimuli is linked to high anxiety and a drive for thinness that could play a role in driving anorexia nervosa.

27 Jul 2018

Scientists identify brain cells that help zebrafishes to socialize

University of Oregon scientists have identified brain cells vital to how zebrafish socialize. When the neurons are disabled, their orientation to one another breaks down in ways similar to socialization problems seen in humans with autism spectrum disorders and schizophrenia.

27 Jul 2018

Medical Condition News

OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

Genetic factors may play a role in progression of liver injury in Caucasians with hepatitis B infection

Portfolio diet reduces risk factors for cardiovascular disease

Diet-induced obesity synchronizes opposing liver fat metabolic processes in mice

Cannabis appears to have no effect on breathlessness during exercise in advanced COPD patients

Researchers investigate how nephrologists should discuss treatment options with older patients

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Therapy with L-Glutamine reduces pain in patients with sickle cell disease

Targeting mossy cells may offer new strategy for treating brain disorders

Newer version of ALS drug may effectively treat inherited form of the disease

Brain scan can help select the right Parkinson’s patients for clinical trials

DePuy Synthes introduces new CONCORDE LIFT Implant to treat patients with degenerative disc disease

Bile acids from the gut may offer new treatment for cocaine abuse

Qualification of first Parkinson's biomarker represents major milestone in clinical trials

Researchers discover new protein that controls level of inflammation-inducing molecule

Scientists take important step to understand mechanisms that cause Huntington's disease

Researchers develop nano-carriers to specifically target senescent cells

Brain's response to taste stimuli could play role in driving anorexia nervosa

Scientists identify brain cells that help zebrafishes to socialize

Membrane proteins in focus: Turning high-risk targets into routine workflows

How metabolic phenotyping can detect viral infections in minutes

Directed enzyme evolution and the Nobel Prize: Making enzymes evolve in the lab

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