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Genotype-guided warfarin dosing linked to reduced risk of adverse events

Using genetic testing to help personalize doses of warfarin therapy given to patients undergoing elective orthopedic surgery appears to lower the risk of combined adverse events compared with clinically guided dosing, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.

21 Mar 2017

Mouse study provides target for development of faster-acting antidepressant medications

Standard antidepressant medications don't work for everyone, and even when they do they are slow to kick in. In an effort to find better depression treatments, researchers at University of California San Diego School of Medicine discovered that inhibiting an enzyme called Glyoxalase 1 (GLO1) relieves signs of depression in mice.

21 Mar 2017

Research findings suggest potential strategies to combat IBMPFD and other degenerative diseases

UCLA researchers have discovered the molecular basis of, and identified potential treatment for, an incurable disease known as inclusion body myopathy, Paget disease with frontotemporal dementia, or IBMPFD.

21 Mar 2017

Tsimane indigenous South Americans have lowest prevalence of coronary atherosclerosis of any population yet studied

The Tsimane people – a forager-horticulturalist population of the Bolivian Amazon – have the lowest reported levels of vascular ageing for any population, with coronary atherosclerosis (hardening of the arteries) being five times less common than in the US, according to a study published in The Lancet and being presented at the American College of Cardiology conference.

21 Mar 2017

New stenting tool found to be less painful and cheaper than current methods

A new tool for assessing the narrowing of the heart's arteries was found to be as effective as current methods and less painful for patients.

21 Mar 2017

New gene-silencing drugs cut cholesterol levels by half in early research

The first in a new class of gene-silencing drugs, known as inclisiran, has been shown to halve cholesterol levels in patients at risk of cardiovascular disease.

21 Mar 2017

Salk scientists develop new way to find responders to lithium therapy

For roughly one-third of people diagnosed with bipolar disorder, lithium is a miracle drug, effectively treating both their mania and depression. But once someone is diagnosed, it can take up to a year to learn whether that person will be among the 30 percent who respond to lithium or the 70 percent who do not.

21 Mar 2017

Researchers develop new way of visualizing distribution of cholesterol in cells, tissues

Researchers from UCLA and the University of Western Australia have developed a new way of visualizing the distribution of cholesterol in cells and tissues.

21 Mar 2017

Researchers develop new method that uses gene editing to find cancer's weak spots

Genetic mutations that cause cancer also weaken cancer cells, creating an opportunity for researchers to develop drugs that will selectively kill them, while sparing normal cells.

20 Mar 2017

Simple fix could eliminate unnecessary coronary stenting procedures

Physician researchers at Thomas Jefferson University suspect that some cases of coronary artery spasm go unrecognized and are incorrectly treated with stents.

20 Mar 2017

New intervention may improve hearing aid wear time among older adults

More than half of older adults have some form of hearing loss, impacting everyday life and significantly affecting their health and safety if left untreated.

20 Mar 2017

Modern guidelines may miss some African-Americans eligible for statin therapy

African Americans experience a disproportionately high risk of cardiovascular disease, and statin treatment can be an important tool to lower the risk of plaque building up in the arteries.

20 Mar 2017

Novel technology enables systematic analysis of linear ubiquitination targets

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many different forms, either as single molecule or in the form of distinct ubiquitin chains, leading to diverse conformations and varying cellular outcomes.

20 Mar 2017

Study shows potential way to prevent formation of scar tissue around medical implants

Medical devices implanted in the body for drug delivery, sensing, or tissue regeneration usually come under fire from the host's immune system.

20 Mar 2017

Single-cell transcriptomic analysis uncovers subgroups of colorectal tumors

Combining single-cell genomics and computational techniques, a research team including Paul Robson, Ph.D., director of single-cell biology at The Jackson Laboratory, has defined cell-type composition of cancerous cells from 11 colorectal tumors, as well as adjacent noncancerous cells, a key to more targeted diagnosis and treatment.

20 Mar 2017

Supplemental use of vitamin E and selenium did not forestall dementia, study finds

Antioxidant supplements vitamin E and selenium - taken alone or in combination - did not prevent dementia in asymptomatic older men, according to a study published online by JAMA Neurology.

20 Mar 2017

Study finds little clinical benefit in placing nasogastric tube for treating upper GI bleeds

For many of the millions of patients treated annually in hospitals for upper gastrointestinal (GI) bleeding, there is little value in placing a nasogastric (NG) tube in patients to determine the source of that bleeding or size of a lesion, report investigators in an article published online ahead of print on January 9, 2017 by the Journal of Investigative Medicine.

20 Mar 2017

MIT researchers devise new strategy to make tumor cells more susceptible to cancer treatment

MIT researchers have devised a way to make tumor cells more susceptible to certain types of cancer treatment by coating the cells with nanoparticles before delivering drugs.

20 Mar 2017

People with family history of alcoholism more likely to hold onto painful memory of hangovers

People with a family history of alcoholism are already known to be at a greater risk of developing a drinking problem, but new research led by Psychologist Dr Richard Stephens at Keele University has found they are also more likely to hold onto the painful memory of hangovers.

20 Mar 2017

Early treatment with stem cells can safely help recovery in stroke patients, study shows

A multicenter trial looking at whether a single dose of millions of adult, bone-marrow-derived stem cells can aid stroke recovery indicates it's safe and well-tolerated by patients but may not significantly improve their recovery within the first three months, researchers report.

20 Mar 2017

Medical Condition News

Genotype-guided warfarin dosing linked to reduced risk of adverse events

Mouse study provides target for development of faster-acting antidepressant medications

Research findings suggest potential strategies to combat IBMPFD and other degenerative diseases

Tsimane indigenous South Americans have lowest prevalence of coronary atherosclerosis of any population yet studied

New stenting tool found to be less painful and cheaper than current methods

New gene-silencing drugs cut cholesterol levels by half in early research

Salk scientists develop new way to find responders to lithium therapy

Researchers develop new way of visualizing distribution of cholesterol in cells, tissues

Researchers develop new method that uses gene editing to find cancer's weak spots

Simple fix could eliminate unnecessary coronary stenting procedures

New intervention may improve hearing aid wear time among older adults

Modern guidelines may miss some African-Americans eligible for statin therapy

Novel technology enables systematic analysis of linear ubiquitination targets

Study shows potential way to prevent formation of scar tissue around medical implants

Single-cell transcriptomic analysis uncovers subgroups of colorectal tumors

Supplemental use of vitamin E and selenium did not forestall dementia, study finds

Study finds little clinical benefit in placing nasogastric tube for treating upper GI bleeds

MIT researchers devise new strategy to make tumor cells more susceptible to cancer treatment

People with family history of alcoholism more likely to hold onto painful memory of hangovers

Early treatment with stem cells can safely help recovery in stroke patients, study shows

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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