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New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Little is known about the molecular basis of aberrant protein glycosylation, a complex enzymatic process that is a hallmark of many human cancers including colorectal cancers (CRC), and how it may contribute to tumor progression. In a new study published in Scientific Reports, an online journal of the Nature Publishing Group, scientists at Case Western Reserve University School of Medicine have successfully characterized the mutational landscapes of glycosylation-associated genes in colon cancer, identifying three glycosyltransferases as significant mutational targets in CRC.

4 Apr 2016

Society of Interventional Radiology honors outstanding achievers with annual awards

Renan Uflacker, M.D., FSIR, was honored posthumously on April 3 with the Society of Interventional Radiology Foundation Leaders in Innovation Award. The award was announced during the Society of Interventional Radiology's Annual Scientific Meeting in Vancouver, British Columbia.

4 Apr 2016

Evolocumab could be more effective than ezetimibe in lowering cholesterol in statin-intolerant patients

In the first major trial of its kind, Cleveland Clinic researchers used a blinded rechallenge with atorvastatin or placebo to objectively confirm the presence of muscle-related symptoms in patients with a history of intolerance to multiple statins and found that evolocumab (a PCSK9 inhibitor) was a more effective option to lower cholesterol than ezetimibe in these patients.

4 Apr 2016

MedUni Vienna researchers identify reason for chemoresistance in small cell lung cancer

Small cell lung cancer is not usually detected until it is at an advanced stage, when metastases have already formed. Chemotherapy is very effective initially but, within a year, cancer recurs and this time does not respond to a course of chemotherapy. The research group headed by Gerhard Hamilton, University Department of Surgery at MedUni Vienna, has now managed to identify the reason for this chemoresistance.

4 Apr 2016

Intravenous beta blockers offer no clinical benefit to patients with STEMI

Giving intravenous beta blockers before performing a coronary angioplasty in patients who had experienced the deadliest form of heart attack—ST-segment elevation myocardial infarction (STEMI)—was safe but did not reduce heart attack severity or improve blood flow from the heart's main pumping chamber, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Bariatric arterial embolization safe, effective in sustaining weight loss in severely obese people

Findings from the early phase of a clinical trial led by Johns Hopkins investigators indicates that a new, minimally invasive weight loss treatment known as bariatric arterial embolization is safe and effective in sustaining weight loss in severely obese people.

4 Apr 2016

Increased consumption of antibiotics in childhood may lead to adolescent prediabetes

Young children who take antibiotics may disrupt their gut's microbial ecosystem and be more likely to develop prediabetes in adolescence, new research from Greece reports. The study results will be presented in a poster Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

4 Apr 2016

Oral Salmonella-based vaccine could prevent Type 1 diabetes

A combined vaccine therapy including live Salmonella is a safe and effective way to prevent diabetes in mice and may point to future human therapies, a new study finds. The results will be on Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

4 Apr 2016

Blast-related concussions result in hormone changes that lead to poor quality of life among veterans

A study in military veterans finds that explosive blast-related concussions frequently result in hormone changes leading to problems such as sleep disturbances, fatigue, depression and poor quality of life. The research, to be presented Saturday at the Endocrine Society's 98th annual meeting in Boston, evaluated hormone levels in 41 male veterans who had been deployed to Iraq or Afghanistan.

4 Apr 2016

Innovative activity toolkit aims to bring benefits to people living with dementia

The University of Stirling is supporting the development of an innovative activity toolkit to encourage creative activities among people living with dementia.

4 Apr 2016

Article provides specific nursing considerations related to caring for patients experiencing prolonged seizure

Time is of the essence when a patient experiences a prolonged seizure, and immediate action is required to prevent long-term neurological damage, according to an article in the April issue of Critical Care Nurse.

4 Apr 2016

New promising therapy may improve curative potential of islet transplant for Type 1 diabetes

New research suggests pretreating cells with a peptide hormone may improve the success rate of pancreatic islet cell transplants, a procedure that holds great promise for curing Type 1 diabetes. The results will be presented Saturday, April 2, at the Endocrine Society's annual meeting, ENDO 2016, in Boston.

4 Apr 2016

Brominated fire retardants overstimulate aldosterone in a way that may lead to cardiovascular disease

Brominated fire retardants, used in many consumer products and known to cause hormonal irregularities, overstimulates an adrenal gland hormone in a way that may lead to the development of cardiovascular disease, new research in human cells finds. Researchers will present their study results Saturday at the Endocrine Society's 98th annual meeting in Boston.

4 Apr 2016

Patient-oriented tool helps shared decision-making between patients and physicians for chest pain

Patients who arrive at the emergency department with low-risk chest pain and talk through treatment options with a physician show improved knowledge of their health status and follow-up options, compared with patients who received standard counseling from a physician, according to Mayo Clinic research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Deferred stent implantation fails to show benefit in STEMI patients

Delayed or deferred stent implantation in patients experiencing the deadliest form of heart attack--ST-segment elevation myocardial infarction (STEMI)—failed to reduce death from any cause, hospitalization for heart failure, subsequent heart attacks or the need for a repeat procedure to restore blood flow to the heart, researchers reported at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Only a small fraction of people with very high cholesterol can attribute their condition to a genetic mutation related to familial hypercholesterolemia, but individuals with these mutations face a high risk of developing early-onset coronary artery disease, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Technology-based virtual race helps participants lose weight, exercise more

A competition that used technology to encourage and track physical activity was effective at helping participants lose weight and exercise more in both developed and developing countries, according to a study presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Researchers compare lipid-lowering efficacy for two nonstatin therapies in statin-intolerant patients

Steven E. Nissen, M.D., of the Cleveland Clinic, and colleagues identified patients with muscle-related adverse effects from statins and compared lipid-lowering efficacy for two nonstatin therapies, ezetimibe and evolocumab. The study was published online by JAMA, and is being released to coincide with its presentation at the American College of Cardiology's 65th Annual Scientific Session & Expo.

4 Apr 2016

Bariatric arterial embolization could offer viable, safe alternative to surgical weight-loss treatments

A safe, new, minimally invasive treatment, developed by interventional radiologists, led to sustained weight loss in severely obese people, according to research presented at the Society of Interventional Radiology's 2016 Annual Scientific Meeting. Researchers said the treatment--bariatric arterial embolization (BAE)--could offer individuals a viable, safe alternative to surgical weight-loss treatments.

4 Apr 2016

Heart disease patients who experience mental stress ischemia tend to have higher levels of troponin

Some people with heart disease experience a restriction of blood flow to the heart in response to psychological stress. Usually silent (not painful), the temporary restriction in blood flow, called ischemia, is an indicator of greater mortality risk.

4 Apr 2016

Medical Condition News

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Society of Interventional Radiology honors outstanding achievers with annual awards

Evolocumab could be more effective than ezetimibe in lowering cholesterol in statin-intolerant patients

MedUni Vienna researchers identify reason for chemoresistance in small cell lung cancer

Intravenous beta blockers offer no clinical benefit to patients with STEMI

Bariatric arterial embolization safe, effective in sustaining weight loss in severely obese people

Increased consumption of antibiotics in childhood may lead to adolescent prediabetes

Oral Salmonella-based vaccine could prevent Type 1 diabetes

Blast-related concussions result in hormone changes that lead to poor quality of life among veterans

Innovative activity toolkit aims to bring benefits to people living with dementia

Article provides specific nursing considerations related to caring for patients experiencing prolonged seizure

New promising therapy may improve curative potential of islet transplant for Type 1 diabetes

Brominated fire retardants overstimulate aldosterone in a way that may lead to cardiovascular disease

Patient-oriented tool helps shared decision-making between patients and physicians for chest pain

Deferred stent implantation fails to show benefit in STEMI patients

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Technology-based virtual race helps participants lose weight, exercise more

Researchers compare lipid-lowering efficacy for two nonstatin therapies in statin-intolerant patients

Bariatric arterial embolization could offer viable, safe alternative to surgical weight-loss treatments

Heart disease patients who experience mental stress ischemia tend to have higher levels of troponin

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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