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Researchers design more effective version of FDA-approved epilepsy drug with fewer side effects

Researchers at the University of Pittsburgh School of Medicine and Arts & Sciences have designed a more effective version of an FDA-approved epilepsy drug with the potential for fewer side effects, according to a study published on March 22 in Molecular Pharmacology. The experimental agent also could prove to be a treatment for tinnitus and other disorders caused by volatile neural signaling.

31 Mar 2016

Penn researchers discover molecular mechanism that underlies common cerebrovascular disease

Cerebral cavernous malformations (CCMs) are clusters of dilated, thin-walled blood vessels in the brain that can cause stroke and seizures, yet exactly how they form is somewhat of a mystery. Now, a team from the Perelman School of Medicine at the University of Pennsylvania has discovered the molecular mechanism that underlies this common cerebrovascular disease. They published their results this week online ahead of print in Nature.

31 Mar 2016

Scientists develop mouse model to gain new insights into genetic mechanisms underlying AML

A novel mouse model of a highly lethal form of acute myeloid leukemia (AML) offers a new tool for scientists working to better understand this disease and research new therapeutic targets.

31 Mar 2016

Baricitinib drug shows significant success in treatment of rheumatoid arthritis

In a clinical phase-3-study, an international research cooperation of MedUni Vienna and Stanford University has achieved significant success with the drug Baricitinib for the treatment of rheumatoid arthritis. The test persons exhibited significantly less symptoms of the disorder. The results are now published in the top scientific journal "New England Journal of Medicine".

31 Mar 2016

Two recently discovered compounds show promise for treating Ewing sarcoma in children

Two recently discovered compounds have shown promise in preclinical studies for treating Ewing sarcoma, a rare cancer that predominantly affects children and adolescents.

31 Mar 2016

Patients undergoing mini-MVR have similar outcomes compared with conventional surgery

Patients undergoing minimally invasive mitral valve repair or replacement (mini-MVR) have similar outcomes as patients undergoing conventional surgery and also experience shorter hospital stays and fewer blood transfusions, according to an article posted online today by The Annals of Thoracic Surgery.

31 Mar 2016

Psychedelic compounds could treat patients with mental health issues

Psychedelic compounds have had a colorful past. Although initially investigated for medical uses, they were banned after cultural and political times changed in the 1960s and 1970s. Now, the compounds are getting another chance in the mainstream, according to the cover story of Chemical & Engineering News, the weekly news magazine of the American Chemical Society.

31 Mar 2016

Naltrexone injections could reduce risk of relapse among opioid dependent individuals

In a multicenter, randomized clinical trial, ex-prisoners who received six monthly injections of naltrexone--a long-acting medication that blocks opioid receptors in the brain--were significantly less likely to resume opioid use than those who received counseling and referrals to community treatment centers without naltrexone.

31 Mar 2016

New Rutgers study links protein that helps fight infection to heart and liver disease

A protein that should help fight infection and keep us healthy may be targeted for treating devastating illnesses like heart and liver disease, according to a new Rutgers study.

31 Mar 2016

Blood test to determine risk of heart disease may benefit middle-aged black women

Middle-aged black women have higher levels of a protein in their blood associated with a predictor of heart disease than their white counterparts, even after other factors, such as obesity, are taken into consideration, according to a study conducted by the University of Pittsburgh Graduate School of Public Health and School of Medicine.

31 Mar 2016

Seizure-free childhood epilepsy could lead to suboptimal social, educational outcomes in young adults

Learning difficulties and behavioral problems during childhood can lead to suboptimal social and educational outcomes among young adults with childhood epilepsy even when their seizures are well under control and their disease in remission, according to findings from a study led by researchers at Ann & Robert H. Lurie Children's Hospital of Chicago.

31 Mar 2016

Key opinions leaders to discuss role of cyclophosphamide in the field of HSCT

Key opinions leaders in the field of haematopoetic stem cell transplantation (HSCT) will address the role of Cyclophosphamide, an anti-cancer chemotherapy drug, during the 42nd Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT) that will welcome more than 4,500 delegates in the host city of Valencia, Spain from the 3rd to the 6th of April 2016.

31 Mar 2016

Opioids could be dangerous, deadly at high doses

Most people know that heroin is a dangerous drug, but its cousins, the legal, pharmaceutical opioids, such as codeine or hydrocodone, must be safe, right?Not so fast.Opioids—which include the illegal drug heroin as well as prescription medications, including hydrocodone (such as Vicodin), oxycodone (such as OxyContin and Percocet), morphine and codeine—can be dangerous, even deadly, at high doses.

31 Mar 2016

UCJC study reveals excessive electrolyte loss may lead to hyponatraemia

Spanish researchers have analysed how the sodium lost through sweat during a marathon influences the maintenance of stable and physiologically sound conditions that allow the body to carry out its functions. Excessive electrolyte loss may lead to a medical problem known as hyponatraemia.

31 Mar 2016

Measuring brain signal variability could help identify patients at higher risk of dementia

Dementia will develop in about 80% of patients with Parkinson's disease, and a new study has found significant variability in brain signaling that could serve as a predictive marker for identifying which patients are at highest risk of dementia.

31 Mar 2016

BodyGuard wearable patch product shows superiority to common NSAID treatments in restoring joint function

Perth skin science technology company OBJ Limited is set to revolutionise treatment of joint injuries and osteoarthritis after its BodyGuard wearable patch product proved its superiority to the world-leading non-steroidal anti-inflammatory drug product Voltaren.

31 Mar 2016

European Medicines Agency approves first-ever treatment for hereditary factor X deficiency

Bio Products Laboratory, Limited (BPL) today announced that the European Medicines Agency has granted marketing authorisation for Coagadex.

31 Mar 2016

New tool may help clinicians provide more personalized treatment strategies following coronary stent procedures

Nearly 1 million people in the United States receive coronary artery stents each year. Nearly all stent patients are expected to take dual antiplatelet therapy (DAPT) using the combination of aspirin and a second antiplatelet medication to prevent the formation of blood clots. Exactly how long patients should receive DAPT has been debatable.

30 Mar 2016

Memory training with unpredictability more effective in enhancing episodic memory

Memory training with unpredictable components could be more effective in enhancing episodic memory than training with predictable elements, according to new findings from UT Dallas researchers published in the journal Frontiers in Psychology.

30 Mar 2016

Study reveals adaptive IGRT for bladder preservation has good oncological outcomes

A prospective study examining a trimodality treatment approach in localized bladder cancer cases using adaptive image-guided, intensity-modulated radiation therapy (IG-IMRT) found that the bladder preservation rate at three years was 83 percent.

30 Mar 2016

Medical Condition News

Researchers design more effective version of FDA-approved epilepsy drug with fewer side effects

Penn researchers discover molecular mechanism that underlies common cerebrovascular disease

Scientists develop mouse model to gain new insights into genetic mechanisms underlying AML

Baricitinib drug shows significant success in treatment of rheumatoid arthritis

Two recently discovered compounds show promise for treating Ewing sarcoma in children

Patients undergoing mini-MVR have similar outcomes compared with conventional surgery

Psychedelic compounds could treat patients with mental health issues

Naltrexone injections could reduce risk of relapse among opioid dependent individuals

New Rutgers study links protein that helps fight infection to heart and liver disease

Blood test to determine risk of heart disease may benefit middle-aged black women

Seizure-free childhood epilepsy could lead to suboptimal social, educational outcomes in young adults

Key opinions leaders to discuss role of cyclophosphamide in the field of HSCT

Opioids could be dangerous, deadly at high doses

UCJC study reveals excessive electrolyte loss may lead to hyponatraemia

Measuring brain signal variability could help identify patients at higher risk of dementia

BodyGuard wearable patch product shows superiority to common NSAID treatments in restoring joint function

European Medicines Agency approves first-ever treatment for hereditary factor X deficiency

New tool may help clinicians provide more personalized treatment strategies following coronary stent procedures

Memory training with unpredictability more effective in enhancing episodic memory

Study reveals adaptive IGRT for bladder preservation has good oncological outcomes

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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