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Research findings may help explain why drug treatments for addiction, depression are not always effective

New research may help explain why drug treatments for addiction and depression don't work for some patients. The conditions are linked to reward and aversion responses in the brain. Working in mice, researchers at Washington University School of Medicine in St. Louis have discovered brain pathways linked to reward and aversion behaviors are in such close proximity that they unintentionally could be activated at the same time.

3 Sep 2015

Imetelstat drug shows promise in treating patients with myelofibrosis

Imetelstat, a novel drug that targets telomerase, has demonstrated potential value in treating patients with myelofibrosis, according to the results of a study published today in the New England Journal of Medicine.

3 Sep 2015

Diabetes may be linked to buildup of brain tangles associated with Alzheimer’s disease

Diabetes may be linked to the buildup of tangles or tau in the brain, separate from Alzheimer's disease, according to a new study published in the September 2, 2015, online version of Neurology, the medical journal of the American Academy of Neurology.

3 Sep 2015

Novel approach to reduce 'bad' lipids in blood circulation

Xian-Cheng Jiang, PhD, professor of cell biology at SUNY Downstate Medical Center, has led a study identifying a new approach for lowering "bad" lipids in blood circulation, a critical means to combat devastating cardiovascular diseases such as atherosclerosis. The research was published in the online edition of Gastroenterology.

3 Sep 2015

Study reveals new epigenetic mechanism underlying progression of cancer tumors

Aggressive cancer growth and alterations in gene activity without changes in DNA sequence (epigenetics) are associated with mutant p53 proteins, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

3 Sep 2015

ISU researcher examines how supplements, resistance training improve muscle strength in older adults

The loss of muscle strength and function, what's known as sarcopenia, is a natural part of aging. It's also a growing public health concern because of the risk for falls, injury and decline in quality of life. That's why an Iowa State University researcher is working to slow or reverse the progression of sarcopenia.

3 Sep 2015

Researchers create method to watch activity of motor neurons in real time

When you're taking a walk around the block, your body is mostly on autopilot--you don't have to consciously think about alternating which leg you step with or which muscles it takes to lift a foot and put it back down. That's thanks to a set of cells in your spinal cord that help translate messages between your brain and your motor neurons, which control muscles.

3 Sep 2015

University of Basel scientists identify genes that play central role in development of Alzheimer's disease

Genes are not only important for regular memory performance, but also for the development of Alzheimer's disease. Researchers at the University of Basel now identified a specific group of genes that plays a central role in both processes. This group of molecules controls the concentration of calcium ions inside the cell.

3 Sep 2015

Exercise training improves quality of life for patients with pulmonary hypertension

Exercise training for patients with pulmonary hypertension was shown to be safe and to improve quality of life, according to an analysis by UT Southwestern Medical Center cardiologists of studies involving more than 400 participants.

3 Sep 2015

Scientists pinpoint neurons responsible for alcohol consumption

Scientists have pinpointed a population of neurons in the brain that influences whether one drink leads to two, which could ultimately lead to a cure for alcoholism and other addictions.

3 Sep 2015

Potential new treatment for sepsis and ARDS

Scientists at Queen's University Belfast are developing a potential revolutionary new treatment for Sepsis and Acute Respiratory Distress Syndrome (ARDS), which are among the leading causes of death in hospitalised patients in the UK.

3 Sep 2015

Tobacco-related cancer risks increase among men in China

In China, smoking now causes nearly a quarter of all cancers in adult males. The finding comes from a large study published early online in CANCER, a peer-reviewed journal of the American Cancer Society, as part of a Special Issue on Lung Cancer in China. High uptake rates of cigarette smoking in teenaged males and continued use in adulthood foreshadow even greater tobacco-related cancer risks for the nation.

3 Sep 2015

Inhalation exposure to PM2.5 pollution triggers liver fibrosis

A research team led by Kezhong Zhang, Ph.D., at the Wayne State University School of Medicine's Center for Molecular Medicine and Genetics, has discovered that exposure to air pollution has a direct adverse health effect on the liver and causes liver fibrosis, an illness associated with metabolic disease and liver cancer.

3 Sep 2015

TMIGD1 protein could be a novel target for restoring kidney function from kidney disease

A new discovery by Boston University School of Medicine (BUSM) researchers may change how kidney disease is treated in the future.

3 Sep 2015

Adaptimmune doses first patient in expanded Phase I/II trial of T-cell therapy for synovial sarcoma

Adaptimmune Therapeutics plc, a clinical stage biopharmaceutical company focused on the use of T-cell therapy to treat cancer, today announced that the first patient has been dosed in its expanded Phase I/II trial of its affinity enhanced T-cell receptor therapeutic targeting the NY-ESO-1 cancer antigen in synovial sarcoma patients.

3 Sep 2015

New study suggests potential use of targeted therapies for two subtypes of esophageal cancer

Nearly all advanced esophageal cancers harbor genetic mutations that can be targeted with emerging drug therapies, according to a new study published in The Oncologist on September 2, 2015.

3 Sep 2015

Researchers develop new method that can target drug delivery to the lung

Researchers from Columbia Engineering and Columbia University Medical Center have developed a new method that can target delivery of very small volumes of drugs into the lung.

3 Sep 2015

Study reveals presence of new genetic mutation in melanoma cancer cells

There is strong evidence that the protein complex APC/C may function as a tumor suppressor in multiple cancers including lymphoma, colorectal and breast cancer, and now melanoma. A new study has revealed that a genetic mutation leading to repression of a specific protein, Cdh1, which interacts with APC/C, is present in melanoma cancer cells.

3 Sep 2015

Amgen announces MAA submission to EMA for novel calcimimetic agent etelcalcetide

Amgen today announced the submission of a Marketing Authorization Application (MAA) to the European Medicines Agency via the centralized procedure for etelcalcetide (formerly AMG 416) for the treatment of secondary hyperparathyroidism (SHPT) in adult patients with chronic kidney disease (CKD) on hemodialysis therapy. If approved, etelcalcetide will be the first calcimimetic agent that can be administered intravenously.

3 Sep 2015

Boca Raton Regional Hospital introduces ultra-minimally invasive procedure for patients with atrial fibrillation

Boca Raton Regional Hospital's Richard G. Cartledge, MD, FACS, has begun performing ultra-minimally invasive left atrial appendage ligation for atrial fibrillation patients who are on anticoagulants such as Coumadin, Xarelto or Effient. Dr. Cartledge, who is Chief of Cardiothoracic Surgery at the Hospital, is one of a select group of surgeons nationally using this method, which involves making two microscopic incisions in order to seal off the left atrial appendage (LAA) in patients where anticoagulants are contraindicated or who refuse to be on such medications.

3 Sep 2015

Medical Condition News

Research findings may help explain why drug treatments for addiction, depression are not always effective

Imetelstat drug shows promise in treating patients with myelofibrosis

Diabetes may be linked to buildup of brain tangles associated with Alzheimer’s disease

Novel approach to reduce 'bad' lipids in blood circulation

Study reveals new epigenetic mechanism underlying progression of cancer tumors

ISU researcher examines how supplements, resistance training improve muscle strength in older adults

Researchers create method to watch activity of motor neurons in real time

University of Basel scientists identify genes that play central role in development of Alzheimer's disease

Exercise training improves quality of life for patients with pulmonary hypertension

Scientists pinpoint neurons responsible for alcohol consumption

Potential new treatment for sepsis and ARDS

Tobacco-related cancer risks increase among men in China

Inhalation exposure to PM2.5 pollution triggers liver fibrosis

TMIGD1 protein could be a novel target for restoring kidney function from kidney disease

Adaptimmune doses first patient in expanded Phase I/II trial of T-cell therapy for synovial sarcoma

New study suggests potential use of targeted therapies for two subtypes of esophageal cancer

Researchers develop new method that can target drug delivery to the lung

Study reveals presence of new genetic mutation in melanoma cancer cells

Amgen announces MAA submission to EMA for novel calcimimetic agent etelcalcetide

Boca Raton Regional Hospital introduces ultra-minimally invasive procedure for patients with atrial fibrillation

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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