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Ketogenic diet restores menstrual cycles and boosts fertility in women with PCOS

A ketogenic diet restored menstrual cycles in all women with PCOS in a study, with over half of those desiring pregnancy achieving it. The diet could be a promising approach to enhance fertility.

15 Sep 2024

Early pregnancy HbA1c predicts gestational diabetes, reducing the need for complex tests

Early pregnancy HbA1c can predict gestational diabetes and reduce the need for oral glucose tolerance tests, improving screening accessibility in diverse populations.

15 Sep 2024

Antibody-drug conjugate shows promise in treating ovarian and endometrial cancers

Studies reported at ESMO 2024 reveal new groups of women with early-stage endometrial and cervical cancers who gain clinically meaningful benefit from adding immunotherapy to current standard treatments, while a first-in-human study found 'promising' antitumor activity with a novel antibody drug conjugate (ADC) targeting the protein claudin 6 in heavily pretreated patients with ovarian and endometrial cancers.

14 Sep 2024

Study reveals challenges of distinguishing autism from BPD

Conducted through interpretive phenomenological analysis, the study involved one-to-one, semi-structured interviews with 10 participants. Each participant recounted unnoticed autistic traits from childhood and described the pervasive impact of a BPD misdiagnosis. The study highlights the challenges of distinguishing between autism and BPD, especially among autistic women, who often face misdiagnosis.

14 Sep 2024

Key enzyme identified as potential target for cancer treatment

During every moment of any living organism's life, enzymes are at work. These crucial proteins support life through most biological processes, including metabolism, movement, respiration, and digestion.

14 Sep 2024

New cancer drug shows encouraging results in Phase I/II trial

The antibody-drug conjugate (ADC) puxitatug samrotecan (AZD8205) demonstrated a manageable safety profile consistent with similar ADCs and initial efficacy in heavily pretreated patients with advanced or metastatic solid tumors, according to interim data shared today at the 2024 European Society for Medical Oncology (ESMO) Congress by researchers from The University of Texas MD Anderson Cancer Center.

14 Sep 2024

Researchers seek early Alzheimer's detection with MRSI

University of Virginia professor Mathews Jacob has secured a $3.9 million grant to advance his innovative research on detecting Alzheimer's disease in its early stages. Jacob, who specializes in electrical and computer engineering, is teaming up with researchers from the University of Iowa and the University of California-San Francisco to push the boundaries of imaging technology that tracks the brain's metabolic changes - offering a fresh perspective on studying neurodegenerative disorders.

14 Sep 2024

Study identifies common misuses of spike-in normalization

Researchers at University of California San Diego have published new guidelines that could help scientists significantly improve their results when quantifying the interactions between DNA and proteins. Understanding these interactions is critical to our understanding of human biology in general, and can also help scientists develop new treatments for a wide range of diseases, including many cancers.

14 Sep 2024

Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

Mount Sinai researchers uncover genetic basis of fibromuscular dysplasia

Mount Sinai researchers have identified a key driver of a blood vessel disorder known as fibromuscular dysplasia (FMD) which affects up to five percent of the adult population and can lead to high blood pressure, heart attack, or stroke.

14 Sep 2024

Scientists develop selective therapy for tau tangles

Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer's disease, and improve symptoms of neurodegeneration in mice.

14 Sep 2024

New insight into the causes of autoimmune diseases

Autoimmune diseases are widespread and notoriously difficult to treat. In part, this is because why the immune system attacks its own tissues in patients with these conditions remains poorly understood.

14 Sep 2024

Real-world data reveals factors associated with long-term weight loss in obesity

A Cleveland Clinic study identified key factors that can impact the long-term weight loss of patients with obesity who were prescribed injectable semaglutide or liraglutide for the treatment of type 2 diabetes or obesity. The study was published in JAMA Network Open.

14 Sep 2024

Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells

Researchers from Weill Cornell Medicine have used a cutting-edge model system to uncover the mechanism by which SARS-CoV-2, the virus that causes COVID-19, induces new cases of diabetes, and worsens complications in people who already have it.

13 Sep 2024

Study sheds light on potential demand for psilocybin-assisted therapy for depression in the U.S.

In the wake of mounting evidence for the efficacy of psychedelic-assisted therapies, the U.S. Food and Drug Administration (FDA) is considering approving psilocybin, the active ingredient in "magic mushrooms," for treating depression in the near future.

13 Sep 2024

Huntsman Cancer Institute celebrates 25 years of innovations in cancer research and care

On September 13, 2024, Huntsman Cancer Institute at the University of Utah (the U), the National Cancer Institute-designated cancer center for the Mountain West, celebrates 25 years of groundbreaking cancer research, education, and patient care.

13 Sep 2024

Semaglutide and tirzepatide significantly improve weight loss and glycemic control in type 1 diabetes

Semaglutide and tirzepatide treatment lead to significant weight loss and improve blood sugar control in individuals with type 1 diabetes (T1D) who are living with overweight or obesity, new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September) has found.

13 Sep 2024