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New culture system confirms amyloid theory, can revolutionize drug discovery for Alzheimer's disease

An innovative laboratory culture system has succeeded, for the first time, in reproducing the full course of events underlying the development of Alzheimer's disease.

13 Oct 2014

Study reveals inner workings of PKA switch that regulates cellular functions, contributes to deadly disorders

A University of Utah-led study using X-rays and neutron beams has revealed the inner workings of a master switch that regulates basic cellular functions, but that also, when mutated, contributes to cancer, cardiovascular disease and other deadly disorders.

13 Oct 2014

Men and women have different cardiovascular, psychological reactions to mental stress

Men and women have different cardiovascular and psychological reactions to mental stress, according to a study of men and women who were already being treated for heart disease.

13 Oct 2014

Findings show that blockade of OGF-OGFr interfacing influences diabetic wound healing

A major complication associated with diabetes is delayed cell replication in epithelium and skin. Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have reported the presence and function of the opioid growth factor (OGF) and its nuclear-associated receptor (OGFr) in skin.

13 Oct 2014

Study: People with PSP experience more severe cognitive impairments than those with PD

Researchers from the University of Melbourne have established how two diseases that present in similar ways are in fact quite different.

13 Oct 2014

Aesthetic procedures following bariatric surgeries may help improve long-term results

Patients who have plastic surgery to reshape their bodies after bariatric procedures are able to maintain "significantly greater" weight loss than those who do not have surgery, according to a new study by Henry Ford Hospital researchers.

13 Oct 2014

New study on global burden of venous thromboembolism

A study on the global burden of venous thromboembolism—when a dangerous clot forms in a blood vessel—found that annual incidences range from 0.75 to 2.69 per 1,000 individuals in the population.

13 Oct 2014

Obesity greatly accelerates aging of the liver

Using a recently developed biomarker of aging known as an epigenetic clock, UCLA researchers working closely with a German team of investigators have found for the first time that obesity greatly accelerates aging of the liver. This finding could explain the early onset of many age-related diseases, including liver cancer, in obese subjects

13 Oct 2014

Blocking STAT3 in immune system cells increases anti-tumour immunity

The STAT transcription factors are involved in the development of many forms of cancer. STAT3 is frequently activated in tumour cells, so drugs targeting STAT3 could be used in cancer therapy. However, STAT3 is also important in the development of the immune system. Dagmar Gotthardt and colleagues at the Vetmeduni Vienna now show that blocking STAT3 in cells of the immune system actually leads to increased anti-tumour immunity. Anti-STAT3 therapy may thus be highly promising.

13 Oct 2014

Hormone loss may cause colon cancer, say Thomas Jefferson University researchers

Some cancers, like breast and prostate cancer, are driven by hormones such as estrogen and testosterone, but to date, there are none that are driven by the lack of a hormone. New evidence suggests that human colon cells may become cancerous when they lose the ability to produce a hormone that helps the cells maintain normal biology. If verified by further studies, it suggests that treating patients at high risk for colon cancer by replacing the hormone guanylin could prevent the development of cancer.

12 Oct 2014

Champalimaud Foundation to establish cancer institute in Rajasthan, India

The Lisbon based Champalimaud Foundation has entered into a partnership with the Government of Rajasthan, India, to establish a state-of-the–art cancer institute with world-class facilities.

12 Oct 2014

Recent clinical study sheds light on potential approach to more personalized care for pancreatic cancer

Pancreatic cancer is one of the deadliest cancers. Even with aggressive treatment, the prognosis is poor, with various factors stacking the odds against successful treatment: early detection is uncommon, it tends to spread quickly and recurrence is likely. However, several newer approaches show promise in increasing the response rate to pancreatic cancer treatment.

10 Oct 2014

NCCN publishes 20th annual editions of NCCN Guidelines for Colon and Rectal Cancers

The National Comprehensive Cancer Network has published the 20th annual editions of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Colon and Rectal Cancers, two of the eight original NCCN Guidelines published in November 1996.

10 Oct 2014

New UCLA study reveals why people with autism experience neural stem cell overgrowth after birth

People with autism spectrum disorder often experience a period of accelerated brain growth after birth. No one knows why, or whether the change is linked to any specific behavioral changes.

10 Oct 2014

Grand Challenges Canada announces 11 seed grants to improve mental health in developing countries

On the day the world is collectively raising awareness on mental health issues, Grand Challenges Canada, funded by the Government of Canada, announced new funding for 11 novel ideas to improve mental health in developing countries, one of the biggest unmet needs of our time. Seed grants of up to $270,000 are awarded to 11 innovators from Canada and low- and middle-income countries, totalling $2.9 million CAD.

10 Oct 2014

Discovery may provide new therapeutic avenue to target autophagy in tumors

No matter what type of chemotherapy you attack a tumor with, many cancer cells resort to the same survival tactic: They start eating themselves.

10 Oct 2014

BIDMC scientists uncover new class of molecules that protects against diabetes

Scientists at the Salk Institute and Beth Israel Deaconess Medical Center in Boston have discovered a new class of molecules—produced in human and mouse fat—that protects against diabetes.

10 Oct 2014

TSRI research points toward new method for treating atherosclerosis

Scientists at The Scripps Research Institute have created a synthetic molecule that mimics "good" cholesterol and have shown it can reduce plaque buildup in the arteries of animal models. The molecule, taken orally, improved cholesterol in just two weeks.

10 Oct 2014

Researchers discover mechanism that leads to generation of new nerve cells after stroke

A previously unknown mechanism through which the brain produces new nerve cells after a stroke has been discovered at Lund University and Karolinska Institutet in Sweden. The findings have been published in the journal SCIENCE.

10 Oct 2014

Penn prediction tool increases sepsis identification and care, indicates fewer deaths

An automated early warning and response system for sepsis developed by Penn Medicine experts has resulted in a marked increase in sepsis identification and care, transfer to the ICU, and an indication of fewer deaths due to sepsis. A study assessing the tool is published online in the Journal of Hospital Medicine.

10 Oct 2014

Medical Condition News

New culture system confirms amyloid theory, can revolutionize drug discovery for Alzheimer's disease

Study reveals inner workings of PKA switch that regulates cellular functions, contributes to deadly disorders

Men and women have different cardiovascular, psychological reactions to mental stress

Findings show that blockade of OGF-OGFr interfacing influences diabetic wound healing

Study: People with PSP experience more severe cognitive impairments than those with PD

Aesthetic procedures following bariatric surgeries may help improve long-term results

New study on global burden of venous thromboembolism

Obesity greatly accelerates aging of the liver

Blocking STAT3 in immune system cells increases anti-tumour immunity

Hormone loss may cause colon cancer, say Thomas Jefferson University researchers

Champalimaud Foundation to establish cancer institute in Rajasthan, India

Recent clinical study sheds light on potential approach to more personalized care for pancreatic cancer

NCCN publishes 20th annual editions of NCCN Guidelines for Colon and Rectal Cancers

New UCLA study reveals why people with autism experience neural stem cell overgrowth after birth

Grand Challenges Canada announces 11 seed grants to improve mental health in developing countries

Discovery may provide new therapeutic avenue to target autophagy in tumors

BIDMC scientists uncover new class of molecules that protects against diabetes

TSRI research points toward new method for treating atherosclerosis

Researchers discover mechanism that leads to generation of new nerve cells after stroke

Penn prediction tool increases sepsis identification and care, indicates fewer deaths

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

Data management challenges in scientific research

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