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Cognitive behavioral therapy enhances the mental well-being and life quality of cancer patients

The impact of cognitive-behavioral treatment on the mental health and quality of life of cancer patients.

23 Aug 2024

Risankizumab outperforms ustekinumab in treating moderate-to-severe Crohn’s disease

Researchers compare the therapeutic efficacy of risakizumab and ustekinumab for the treatment of moderate-to-severe Crohn’s disease.

23 Aug 2024

Maternal smoking increases risk of severe neonatal morbidity, even at low intensity

Researchers explore the association between severe neonatal morbidity and maternal smoking before or during pregnancy.

23 Aug 2024

Multimodal therapy shows promise for cancer treatment

Cancer remains one of the most challenging diseases to treat due to its complexity and tendency to metastasize (spread into or invade, nearby tissues or distant places in the body to form new tumors). Traditional therapies, such as chemotherapy and radiation, often face limitations like non-specific targeting and severe side effects. In response, researchers are turning to innovative approaches that combine multiple therapeutic modalities to address these issues. This study explores a cutting-edge solution involving CNHs to create a multimodal cancer phototheranostic platform integrating photothermal therapy (PTT), immunotherapy, and chemotherapy.

23 Aug 2024

New analytical method for identifying cancer cell targets

What are the characteristics of a cancer cell that are recognized by the immune system? Knowledge of the potential target structures for the immune cells is a basic prerequisite for the development of personalized cancer immunotherapies. Scientists from the German Cancer Research Center (DKFZ) and the NCT Heidelberg are publishing a highly sensitive method based on mass spectroscopy to identify such tumor-specific "neoepitopes". The analytical method is designed to detect these low-abundance protein fragments and requires minimal amounts of sample material.

23 Aug 2024

Novel screening method for blood-brain barrier penetration

Scientists at Southwest Research Institute have developed a new screening method to identify drug formulations that can penetrate the blood-brain barrier (BBB), to facilitate treatment of brain diseases and conditions.

23 Aug 2024

Olaparib effective against BRCA2-mutated prostate cancer

The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2, according to results of a phase II clinical trial of 51 patients conducted at the Johns Hopkins Kimmel Cancer Center and three other sites.

23 Aug 2024

FDA-approved drug could revolutionize organ transplantation

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University report that they were able to successfully put tadpoles of Xenopus laevis frogs into a hibernation-like torpor state using donepezil (DNP), a drug approved by the FDA to treat Alzheimer's. The team had previously used another drug, SNC80, to achieve similar results in tadpoles and enhance the survival of whole mammalian hearts for transplants, but SNC80 is not approved for clinical use in humans because it can cause seizures. By contrast, DNP is already being used in the clinic, meaning it potentially could be rapidly repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital.

23 Aug 2024

Immune cells' two-pronged approach to maintaining acetyl-CoA reserves

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.

23 Aug 2024

Promising new approach to treating type 2 diabetes

An estimated 462 million people around the world suffer from Type 2 diabetes, a chronic disease in which the body has problems using sugar as a fuel, leading to a buildup of sugar in the blood and chronic health issues.

23 Aug 2024

Rising IBD incidence highlights need for non-invasive biomarkers in diagnosis

The global burden of inflammatory bowel diseases (IBD), primarily Crohn's disease (CD) and ulcerative colitis (UC), continues to rise. Recent data show incidence rates of up to 17.8 cases per 100,000 person-years for CD and even higher for UC, reaching 28.4 per 100,000 person-years. These diseases primarily affect older populations and vary geographically, with higher prevalence rates in highly developed countries.

23 Aug 2024

Experts release revised lung cancer testing guidelines

The College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) announced today the open comment period for the revised 2018 evidence-based guideline, "Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors."

23 Aug 2024

Redlined communities face higher mental health risks from air pollution

Air pollution is bad for mental health. That much is clear. Now, new research shows the impact may be even worse in neighborhoods that were historically redlined.

23 Aug 2024

Kynurenine pathway blockade shows promise for restoring brain metabolism in Alzheimer's

Among the many ways neuroscientists think Alzheimer's disease may strip away brain function is by disrupting the glucose metabolism needed to fuel the healthy brain.

22 Aug 2024

Anti-obesity medication may help to prevent heart attacks and other major cardiac events

The anti-obesity medication semaglutide may help to prevent heart attacks and other major adverse cardiac events among overweight people who have cardiovascular disease, whether or not they also have heart failure, according to a new study led by UCL's Professor John Deanfield.

22 Aug 2024

New insights into macrophages' role in MASH and liver fibrosis

Formerly known as nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory disease characterized by liver scarring or fibrosis that progressively impairs liver function.

22 Aug 2024

New 3D imaging tool offers accurate assessment of metabolic health

Mayo Clinic researchers are using artificial intelligence (AI) with an advanced 3D body-volume scanner – originally developed for the clothing industry – to help doctors predict metabolic syndrome risk and severity.

22 Aug 2024

Cancer drug holds promise as a new treatment for neurodegenerative diseases

A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a recent study by researchers at Penn State, Stanford University and an international team of collaborators.

22 Aug 2024

Robotic gait training improves mobility in patients with spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA) is a rare X-linked neuromuscular disorder that results from an abnormal expansion of gene sequences in the androgen receptor gene.

22 Aug 2024

Study reveals how macrophages affect cardiac fibroblast fate post-myocardial infarction

The research uncovers a previously unappreciated mechanism by which macrophages influence the fate of CFs post-MI.

22 Aug 2024

Medical Condition News

Cognitive behavioral therapy enhances the mental well-being and life quality of cancer patients

Risankizumab outperforms ustekinumab in treating moderate-to-severe Crohn’s disease

Maternal smoking increases risk of severe neonatal morbidity, even at low intensity

Multimodal therapy shows promise for cancer treatment

New analytical method for identifying cancer cell targets

Novel screening method for blood-brain barrier penetration

Olaparib effective against BRCA2-mutated prostate cancer

FDA-approved drug could revolutionize organ transplantation

Immune cells' two-pronged approach to maintaining acetyl-CoA reserves

Promising new approach to treating type 2 diabetes

Rising IBD incidence highlights need for non-invasive biomarkers in diagnosis

Experts release revised lung cancer testing guidelines

Redlined communities face higher mental health risks from air pollution

Kynurenine pathway blockade shows promise for restoring brain metabolism in Alzheimer's

Anti-obesity medication may help to prevent heart attacks and other major cardiac events

New insights into macrophages' role in MASH and liver fibrosis

New 3D imaging tool offers accurate assessment of metabolic health

Cancer drug holds promise as a new treatment for neurodegenerative diseases

Robotic gait training improves mobility in patients with spinal and bulbar muscular atrophy

Study reveals how macrophages affect cardiac fibroblast fate post-myocardial infarction

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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