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New method to target, eliminate cancer-supporting macrophages in mouse tumors

When a person has cancer, some of the cells in his or her body have changed and are growing uncontrollably. Most cancer drugs try to treat the disease by killing those fast-growing cells, but another approach called immunotherapy tries to stimulate a person's own immune system to attack the cancer itself.

17 Sep 2013

Acacia Pharma initiates two pivotal Phase 3 studies of APD421 in prevention of PONV

Acacia Pharma, a pharmaceutical company specialising in the development of drugs for supportive care, announces the initiation of two pivotal Phase 3 studies of APD421 in the prevention of post-operative nausea & vomiting (PONV).

17 Sep 2013

arGEN-X announces CTA filing of Phase Ib cancer study with ARGX-111

arGEN-X, a clinical stage human monoclonal antibody therapeutics company, announces today the CTA filing of a first-in-man Phase Ib cancer study with ARGX-111, its second proprietary SIMPLE Antibody product to enter the clinic this year.

17 Sep 2013

Research finding offers new approach to treating melanoma

Scientists at Sanford-Burnham Medical Research Institute today announced the discovery that a gene encoding an enzyme, phosphoinositide-dependent kinase-1, plays an essential role in the development and progression of melanoma. The finding offers a new approach to treating this life-threatening disease.

17 Sep 2013

Oil spill exposure appears to play role in development of hematologic and hepatic toxicity

A new study reports that workers exposed to crude oil and dispersants used during the Gulf oil spill cleanup display significantly altered blood profiles, liver enzymes, and somatic symptoms compared to an unexposed control group.

17 Sep 2013

Spinal injuries present in 11% of Iraq/Afghanistan casualties

Spinal injuries are present in 1 out of 9 U.S. military personnel sustaining combat injuries in Iraq or Afghanistan -- a much higher rate than in previous wars, according to a report in the Sept. 15 issue of Spine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

17 Sep 2013

Expert offers tips to help college students avoid serious health conditions down the road

To attract customers, restaurant chains have been rolling out budget deals, offering $5 pizzas, $3 meals — even $1 sandwiches. But while these new offerings are light on its customers' wallets, they hit them where it hurts in terms of calories, fat, and sodium content.

17 Sep 2013

New study finds more burnout, depression among physicians who work long hours

Spare a thought for American doctors and their partners: because of long working hours and dedication to their work, they seem to have more squabbles over home and family responsibilities than people in most other professions.

17 Sep 2013

NIEHS grant renewal opens next chapter in 18-year research effort into brain injury biomarker

The National Institute of Environmental Health Sciences (NIEHS) has awarded a five-year, $1.5 million grant extension to Columbia University's Mailman School of Public Health to fund research into the function of a biomarker for brain injury called Translocator Protein 18 kDa, better known as TSPO, in order to better understand its function in brain injury and inflammation and discover targets for therapy.

17 Sep 2013

TSRI scientists find new way to boost effectiveness of anticancer drugs

Scientists at The Scripps Research Institute (TSRI) have found a way to make dramatic improvements to the cancer cell-killing power of vinblastine, one of the most successful chemotherapy drugs of the past few decades.

17 Sep 2013

Varenicline drug helps people with depression quit smoking, say researchers

About half of smokers seeking treatment for smoking cessation have a history of depression. Compared with smokers who are not depressed, those who suffer from a major depressive disorder have greater difficulty quitting.

17 Sep 2013

Flecainide, encainide drugs increase risk of sudden cardiac death

Scientists have discovered that a drug which increases the risk of sudden cardiac death interacts with mistranslated protein-coding genes present in heart muscle.

17 Sep 2013

Hospitalizations for endocarditis have declined in recent years

Hospitalizations for endocarditis, a deadly heart infection that disproportionately affects older heart patients, have declined in recent years despite recommendations for limited use of antibiotics to prevent the illness. These findings were recently published by Yale School of Medicine researchers in the Journal of the American College of Cardiology.

17 Sep 2013

Recanalization of extracranial internal carotid artery occlusion: A retrospective study

Carotid endarterectomy can benefit the majority of patients with severe carotid artery stenosis. However, the therapeutic effects of this technique in patients with symptomatic internal carotid artery occlusion remain controversial.

17 Sep 2013

Study reports identification of IDH1 protein as novel biomarker for diagnosis of NSCLC

A protein called isocitrate dehydrogenase is present at high levels in lung cancers and can be detected in the blood, making it a noninvasive diagnostic marker for lung cancers, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

17 Sep 2013

Understanding essential role of gut microbes in immune system

A new understanding of the essential role of gut microbes in the immune system may hold the key to dealing with some of the more significant health problems facing people in the world today, Oregon State University researchers say in a new analysis.

17 Sep 2013

Patients with pre-existing dementia may experience delirium when hospitalized

More than half of all patients with pre-existing dementia will experience delirium while hospitalized. Failing to detect and treat their delirium early leads to a faster decline of both their physical and mental health, according to health researchers.

17 Sep 2013

microRNA-486 found to be potent tumor-suppressor molecule in lung cancer

New research shows that microRNA-486 is a potent tumor-suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung-cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

17 Sep 2013

Researchers find mucus-regulating protein receptors out of control in uterine, pancreatic cancers

A "vicious cycle" produces mucus that protects uterine and pancreatic cancer cells and promotes their proliferation, according to researchers at Rice University. The researchers offer hope for a therapeutic solution.

17 Sep 2013

High exposure to swine manure in crop fields linked with increased risk of MRSA, soft-tissue infection

High exposure to swine manure spread in crop fields and proximity to high-density swine livestock operations appear to be associated with increased risk of methicillin-resistant Staphylococcus aureus (MRSA) and skin and soft-tissue infection in humans, according to a study published by JAMA Internal Medicine, a JAMA Network publication.

17 Sep 2013

Medical Condition News

New method to target, eliminate cancer-supporting macrophages in mouse tumors

Acacia Pharma initiates two pivotal Phase 3 studies of APD421 in prevention of PONV

arGEN-X announces CTA filing of Phase Ib cancer study with ARGX-111

Research finding offers new approach to treating melanoma

Oil spill exposure appears to play role in development of hematologic and hepatic toxicity

Spinal injuries present in 11% of Iraq/Afghanistan casualties

Expert offers tips to help college students avoid serious health conditions down the road

New study finds more burnout, depression among physicians who work long hours

NIEHS grant renewal opens next chapter in 18-year research effort into brain injury biomarker

TSRI scientists find new way to boost effectiveness of anticancer drugs

Varenicline drug helps people with depression quit smoking, say researchers

Flecainide, encainide drugs increase risk of sudden cardiac death

Hospitalizations for endocarditis have declined in recent years

Recanalization of extracranial internal carotid artery occlusion: A retrospective study

Study reports identification of IDH1 protein as novel biomarker for diagnosis of NSCLC

Understanding essential role of gut microbes in immune system

Patients with pre-existing dementia may experience delirium when hospitalized

microRNA-486 found to be potent tumor-suppressor molecule in lung cancer

Researchers find mucus-regulating protein receptors out of control in uterine, pancreatic cancers

High exposure to swine manure in crop fields linked with increased risk of MRSA, soft-tissue infection

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