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Researchers find master regulator of EMT and metastasis

The predominant cause of death in cancer patients is metastasis, the formation of secondary tumors in other organs like the brain, liver, and lungs. Cancer cells detach from the original primary tumor and reach a single cell or group of cells in another organ. The cells of the body normally remain in place through adhering to an extracellular substance. However, cancer cells learn how to release themselves from these bonds and invade surrounding tissues, blood, and the lymphatic system.

11 Jun 2013

African medicinal plants contain chemicals that may help stop spread of cancer cells

African medicinal plants contain chemicals that may be able to stop the spread of cancer cells. This is the conclusion of researchers following laboratory experiments conducted at Johannes Gutenberg University Mainz (JGU).

10 Jun 2013

Novel method introduced for detecting retinal micro-aneurysms that pose high risk for leakage

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., the technology transfer arm of the Hebrew University, introduces a novel method for detecting retinal micro-aneurysms that pose a high risk for leakage, an underlying cause of diabetic retinopathy.

10 Jun 2013

Bone tumor identified in the rib of 120,000-year-old Neandertal

The first-known definitive case of a benign bone tumor has been discovered in the rib of a young Neandertal who lived about 120,000 years ago in what is now present-day Croatia.

10 Jun 2013

Scientists find that mice develop age-related progressive motor symptoms of Parkinson's disease

The presence of Lewy bodies in nerve cells, formed by intracellular deposits of the protein α-synuclein, is a characteristic pathologic feature of Parkinson's Disease (PD). In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α-synuclein.

10 Jun 2013

Women can be screened for colorectal cancer later than men undergoing "virtual colonoscopy"

A new study has found that women can be screened for colorectal cancer at least five to 10 years later than men when undergoing an initial "virtual colonoscopy." Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings may help establish guidelines for the use of this screening technique, which is less invasive than a traditional colonoscopy.

10 Jun 2013

Discovery sheds new light on causes of debilitating diseases and birth defects

Danish researchers have just published findings that explain a previously unknown mechanism used by cells to communicate with one another. The research significantly contributes to understanding why some children are born with malformations and why children and adults may develop life-threatening diseases.

10 Jun 2013

Discovery highlights protective role of liver enzyme in treating jaundice

Helping to protect newborns and older patients against more severe effects of jaundice is the hope of University of Guelph researchers, who have shown how a liver enzyme protects cells from damage caused by the condition.

10 Jun 2013

Concert Pharmaceuticals announces initiation of CTP-354 Phase 1 trial in healthy volunteers

Concert Pharmaceuticals, Inc. today announced that it has initiated a Phase 1 clinical trial with CTP-354. CTP-354 is a novel GABAA receptor subtype-selective modulator that has demonstrated no sedation at therapeutic doses in preclinical models in contrast to existing GABAA receptor non-selective agonists, such as benzodiazepines.

10 Jun 2013

MRI scans of children who have undergone chemotherapy can detect early changes in their hearts

MRI scans of children who have had chemotherapy can detect early changes in their hearts finds research in biomed Central's open access journal Journal of Cardiovascular Magnetic Resonance.

10 Jun 2013

Exact Sciences announces submission of final module of PMA application to FDA for Cologuard

Exact Sciences Corp. today announced that it has submitted to the U.S. Food and Drug Administration the final module of the premarket approval application for Cologuard, the company's stool DNA (sDNA) colorectal cancer screening test.

10 Jun 2013

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

A drug used to control Type II diabetes can help repair the spinal cords of mice suffering from the inherited disease adrenoleukodystrophy which, untreated, leads eventually to a paralysis, a vegetative state and death.

10 Jun 2013

Brain-training computer games may help restore memory and competency to forensic psychiatry patients

Brain-training computer games may help restore memory and competency to forensic psychiatry patients in state mental hospitals, researchers say.

10 Jun 2013

First Edition: June 10, 2013

Today's headlines include reports about President Barack Obama's efforts last week to urge uninsured people to sign up for the coverage that will soon become unavailable as a result of the health law.

10 Jun 2013

New non-invasive test measures methylation of SDC2 gene, detects 87% of colorectal cancer

The average 5-year survival for colorectal cancer (CRC) is less than 10% if metastasis occurs, but can reach 90% if detected early. A new non-invasive test has been developed that measures methylation of the SDC2 gene in tissues and blood sera.

10 Jun 2013

Common antidepressant medications may impair a form of learning, new report suggests

An interesting new report of animal research published in Biological Psychiatry suggests that common antidepressant medications may impair a form of learning that is important clinically.

10 Jun 2013

AVEO Oncology receives Complete Response letter from FDA for tivozanib NDA

AVEO Oncology today announced that it has received a Complete Response letter from the U.S. Food and Drug Administration informing the company that the FDA will not approve in its present form the New Drug Application for AVEO's investigational agent tivozanib for the treatment of patients with advanced renal cell carcinoma.

10 Jun 2013

Edge Therapeutics announces FDA acceptance of IND application for EG-1962

Edge Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing and commercializing life-saving hospital products for acute, fatal or debilitating conditions, announced today that the U.S. Food and Drug Administration has accepted the Company's Investigational New Drug application for EG-1962, a novel bio-absorbable nimodipine microparticle formulation.

10 Jun 2013

Whitehead Institute researchers identify drug target for anemia

Researchers at Whitehead Institute have identified a protein that is the target of glucocorticoids, the drugs that are used to increase red blood cell production in patients with certain types of anemia, including those resulting from trauma, sepsis, malaria, kidney dialysis, and chemotherapy.

10 Jun 2013

Arthritis estimated to cost $33 billion annually to the Canadian economy

Siena Pacheco is five years old, and enjoys swimming and riding her bike. Sheila Stone has a few years on Siena, but she also enjoys swimming and cycling, and the kindergarten teacher insists she still has the spirit of a five-year-old.

10 Jun 2013

Medical Condition News

Researchers find master regulator of EMT and metastasis

African medicinal plants contain chemicals that may help stop spread of cancer cells

Novel method introduced for detecting retinal micro-aneurysms that pose high risk for leakage

Bone tumor identified in the rib of 120,000-year-old Neandertal

Scientists find that mice develop age-related progressive motor symptoms of Parkinson's disease

Women can be screened for colorectal cancer later than men undergoing "virtual colonoscopy"

Discovery sheds new light on causes of debilitating diseases and birth defects

Discovery highlights protective role of liver enzyme in treating jaundice

Concert Pharmaceuticals announces initiation of CTP-354 Phase 1 trial in healthy volunteers

MRI scans of children who have undergone chemotherapy can detect early changes in their hearts

Exact Sciences announces submission of final module of PMA application to FDA for Cologuard

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

Brain-training computer games may help restore memory and competency to forensic psychiatry patients

First Edition: June 10, 2013

New non-invasive test measures methylation of SDC2 gene, detects 87% of colorectal cancer

Common antidepressant medications may impair a form of learning, new report suggests

AVEO Oncology receives Complete Response letter from FDA for tivozanib NDA

Edge Therapeutics announces FDA acceptance of IND application for EG-1962

Whitehead Institute researchers identify drug target for anemia

Arthritis estimated to cost $33 billion annually to the Canadian economy

Fourier 80: bringing benchtop NMR systems to the laboratory

How industrial hygiene flow calibration supports defensible exposure data

How electrical engineering ensures accurate calibration and patient safety

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