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Researchers generate artificial thymus tissue to enable T cell maturation

The thymus plays a key role in the body's immune response. It is here where the T lymphocytes or T cells, a major type of immune defence cells, mature. Different types of T cells, designated to perform specific tasks, arise from progenitor cells that migrate to the thymus from the bone marrow. Researchers at the Max Planck Institute of Immunology and Epigenetics in Freiburg have generated artificial thymus tissue in a mouse embryo to enable the maturation of immune cells.

30 Mar 2012

Thyroidectomy may increase risk of postoperative complications in the elderly

Elderly patients who undergo thyroid surgery are at a much higher risk than their younger counterparts for serious cardiac, pulmonary and infectious complications, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

30 Mar 2012

Mind-pop experiences are related to hallucinations in people with schizophrenia

Almost everyone reports experiencing mind-pops at some time or another, but some experience them more than others according to research conducted by the University of Hertfordshire. In the paper to be published in Psychiatry Research, findings suggest that mind-pop experiences are related to hallucinations in those people suffering from schizophrenia.

30 Mar 2012

Scientists identify potential drug target for mixed lineage leukaemia

Cancer Research UK scientists have discovered a promising new approach to treat a type of myeloid leukaemia - a cancer with limited treatment options and relatively poor survival, according to research published in Cancer Cell today.

30 Mar 2012

Researchers unravel critical regulatory mechanism behind angiogenesis

Max Planck researchers unravel a critical regulatory mechanism controlling blood vessel growth that might help solve drug resistance problems in the future.

30 Mar 2012

Study explains how rapamycin also causes insulin resistance

A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend on inhibiting two protein complexes, mTORC1 and mTORC2, respectively.

30 Mar 2012

Bilingualism can offer protection from symptoms of dementia

New research explains how speaking more than one language may translate to better mental health. A paper published by Cell Press in the March 29th issue of the journal Trends in Cognitive Sciences examines how being bilingual can offer protection from the symptoms of dementia, and also suggests that the increasing diversity in our world populations may have an unexpected positive impact on the resiliency of the adult brain.

30 Mar 2012

XRCC2 gene mutations cause increased breast cancer risk

Mutations in a gene called XRCC2 cause increased breast cancer risk, according to a study published today in the American Journal of Human Genetics. The study looked at families that have a history of the disease but do not have mutations in the currently known breast cancer susceptibility genes.

30 Mar 2012

Dementia numbers to triple by 2050: Australian Report

In a discussion paper given to the State Government, Alzheimer's Australia NSW estimates the number of Australians diagnosed with dementia will rise from 280,000 to around 943,000 by 2050. Of these, 303,500 people will be from NSW.

29 Mar 2012

Two drinks a day after first heart attack may reduce death risk among men: Study

The study, carried out by researchers at Brigham and Women's Hospital in Boston, found that men who consumed two alcoholic drinks per day after their first heart attack were at lower risk of dying than non-drinking men. The type of drink did not have an effect on the results, but heavy drinkers had a risk of death that was similar to that of non-drinkers.

29 Mar 2012

Latest updates in clinical practice decision-making in cancer care presented at NCCN 17th conference

The National Comprehensive Cancer Network (NCCN) held the NCCN 17th Annual Conference: Clinical Practice Guidelines & Quality Cancer Care, March 14 - 18 at The Westin Diplomat in Hollywood, Florida. The latest updates in clinical practice decision-making in cancer care were presented, including, but not limited to, the new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening and updates to the NCCN Guidelines for Melanoma and Non-Hodgkin's Lymphomas.

29 Mar 2012

Lilly's ixekizumab Phase II trial on plaque psoriasis meets primary endpoint

New Phase II data, published today in the New England Journal of Medicine, showed that Eli Lilly and Company's ixekizumab, an anti-IL-17 monoclonal antibody, met its primary endpoint in patients with moderate-to-severe plaque psoriasis, with significantly more patients achieving at least a 75 percent improvement in Psoriasis Area and Severity Index (PASI) scores from baseline (PASI 75) compared with placebo at week 12.

29 Mar 2012

BMI not linked with either surgical complications or esophageal cancer patient survival

Researchers at Moffitt Cancer Center in Tampa, Fla., have found - contrary to previous studies linking inferior outcomes in patients with gastrointestinal malignancies to higher body mass index (BMI) - that in their study of BMI and negative outcomes, there was no such link. They concluded that BMI was not associated with either surgical complications or esophageal cancer patient survival.

29 Mar 2012

Enrolment complete in Veloxis LCP-Tacro Phase III study in de novo kidney transplant patients

Veloxis Pharmaceuticals A/S today announced that enrolment has been completed in its pivotal LCP-Tacro Phase III study in de novo kidney transplant patients. The LCP-Tacro 3002 study is designed to demonstrate non-inferiority versus the gold standard therapy Prograf and has randomized over 540 patients at approximately 90 clinical sites around the world.

29 Mar 2012

Papillary renal cell carcinoma patients face low tumour re-occurrence and cancer-related death rates

Patients with papillary renal cell carcinoma, the second most common kidney cancer subtype, face a low risk of tumour recurrence and cancer-related death after surgery. Those are the key findings of a multi-centre study of nearly 600 patients published in the April issue of the urology journal BJUI.

29 Mar 2012

Rare total shoulder replacement performed using rotator cuff sparing approach

On Tuesday, March 6, 2012, Ryan Simovitch, M.D., Board Certified and fellowship trained orthopedic surgeon, performed one of the first successful total shoulder replacements with a rotator cuff sparing technique in South Florida. Jupiter Medical Center remains on the leading edge of orthopedics, offering orthopedic surgeons, state-of-the-art facilities, and comprehensive rehabilitation services to help patients return to an active and healthy lifestyle.

29 Mar 2012

Albumin best choice for prevention of circulatory dysfunction in cirrhotic patients

Administration of albumin reduces morbidity and mortality in cirrhotic patients undergoing large-volume paracentesis due to severe ascites, according to a new meta-analysis published online today in Hepatology, the official journal of the American Association for the Study of Liver Diseases.

29 Mar 2012

COPD Foundation to lead DRIVE4COPD campaign

The successful national campaign to increase public awareness of COPD changed organizational leadership effective March 23, 2012. Led since inception by Boehringer Ingelheim Pharmaceuticals Inc., a leader in developing medicines to treat COPD, the DRIVE4COPD campaign will now be led by the COPD Foundation, a not-for-profit organization dedicated to the education, early diagnosis, research and enhanced therapy for people with lives impacted by COPD.

29 Mar 2012

Ember adds Joslin's BMP7 technology to brown fat intellectual property portfolio

Ember Therapeutics, Inc., a company harnessing breakthroughs in brown fat biology and insulin sensitization to revolutionize the treatment of metabolic disease, today announced the completion of an agreement with the Joslin Diabetes Center to exclusively license intellectual property covering bone morphogenetic protein 7 (BMP7), which has been shown to play a role in the regulation of brown fat development.

29 Mar 2012