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FDA assigns new PDUFA date for Takeda's investigational type 2 diabetes therapy, alogliptin

Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Global Research & Development Center, Inc., U.S., today announced that the company received notification from the U.S. Food and Drug Administration (FDA) that its review of investigational type 2 diabetes therapy alogliptin, and thus the fixed-dose combination therapy alogliptin/pioglitazone, will be delayed.

18 Nov 2011

Tonix to initiate TNX-102 PK and BA study for fibromyalgia

Tonix Pharmaceuticals Holding Corp., a specialty pharmaceutical company developing therapies for challenging disorders of the central nervous system, including fibromyalgia syndrome and post-traumatic stress disorder, will initiate a comparative pharmacokinetic and bioavailability study of TNX-102, a novel dosage oral formulation of cyclobenzaprine for the treatment of FM, following the U.S. Food and Drug Administration clearance of the Company's initial Investigational New Drug Application.

18 Nov 2011

Eurozone cancer researchers praise AICR for vital grants

AS the ripples from the ongoing crisis in the eurozone continue to spread, cancer researchers in the countries worst affected warned today that their work would have stalled without vital grants from a Scottish charity.

18 Nov 2011

The AJMS launches new series on 'Pathophysiology in Medicine'

As scientific research delves into the processes underlying human disease, doctors are challenged to integrate these new discoveries into patient care. To help bridge the gap between basic science research and clinical practice, a new series on "Pathophysiology in Medicine" begins this month in The American Journal of the Medical Sciences (The AJMS), official journal of the Southern Society for Clinical Investigation.

18 Nov 2011

Important clues to prevention and management of delirium are being ignored

Important clues to the prevention and management of delirium, a condition affecting an estimated 7 million hospitalized Americans, are being ignored, according to a study from the Regenstrief Institute and the Indiana University School of Medicine.

18 Nov 2011

UK to offer master's degree in music therapy

The University of Kentucky will be the first higher education institution in the Commonwealth of Kentucky to offer a graduate degree in music therapy. The program, housed at the UK School of Music, was officially approved by the state's Council on Postsecondary Education earlier in November and will start accepting graduate students in the spring of 2012.

18 Nov 2011

New protein in the fruit fly eye may shed light on neurodegenerative diseases

Researchers at the University of Wisconsin-Madison and collaborators have discovered a powerful new protein in the eye of the fruit fly that may shed light on blinding diseases and other sensory problems in humans.

18 Nov 2011

NewYork-Presbyterian/Columbia opens Center for Acute Respiratory Failure

NewYork-Presbyterian Hospital/Columbia University Medical Center has officially opened the Center for Acute Respiratory Failure, which offers, among other services, expertise in using lung bypass technology to help adult patients whose lungs are rapidly shutting down.

18 Nov 2011

University of Haifa leads new computerized medical information systems research project

University of Haifa leads a new international computerized medical information systems research project, funded by the EU with total budget of €6 million.

18 Nov 2011

Dendrimers can capture circulating tumor cells in blood by biomimicry

The removal of rare tumor cells circulating in the blood might be possible with the use of biomolecules bound to dendrimers, highly branched synthetic polymers, which could efficiently sift and capture the diseased cells, according to new research at the University of Illinois at Chicago.

18 Nov 2011

Simple roundworm may serve as ideal skin wound healing lab model

The lowly and simple roundworm may be the ideal laboratory model to learn more about the complex processes involved in repairing wounds and could eventually allow scientists to improve the body's response to healing skin wounds, a serious problem in diabetics and the elderly.

18 Nov 2011

NYU Langone cardiovascular experts present new research findings at AHA 2011

Experts from the Cardiac & Vascular Institute at NYU Langone Medical Center presented new research findings at the American Heart Association Scientific Sessions 2011 held November 12-16, 2011 in Orlando, Florida.

18 Nov 2011

Blocking CaM kinase may help prevent cardiac rupture

For people who initially survive a heart attack, a significant cause of death in the next few days is cardiac rupture -- literally, bursting of the heart wall. A new study by University of Iowa researchers pinpoints a single protein as the key player in the biochemical cascade that leads to cardiac rupture.

18 Nov 2011

AHA honors Gladstone scientist with Katz award for cardiovascular research

Li Qian, PhD, has won the Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigators from the American Heart Association (AHA), marking the first time in the prestigious award's history that a Gladstone Institutes researcher has been the recipient.

18 Nov 2011

World's fastest program to examine interactions between molecules

Creating new, improved pharmaceuticals is sometimes very similar to cracking the code of a combination lock. If you have the wrong numbers, the lock won't open. Even worse, you don't know if your numbers are close to the actual code or way off the mark. The only solution is to simply guess a new combination and try again.

18 Nov 2011

CINJ experts available to comment on blood donations

Every two seconds, someone in the United States is in need of blood. According to the American Red Cross, more than 38,000 blood donations are needed each day. With just one donation of a pint of blood, up to three lives can be saved. In New Jersey, according to the state Department of Health and Senior Services, fewer than four percent of eligible residents donate regularly, resulting in the need for critical blood donations.

18 Nov 2011

VSL#3 classified as refrigerated medical food for three GI conditions

As clinical studies continue to validate the use of probiotics to help promote general gastrointestinal health, a growing U.S. market for probiotics indicates that the U.S. healthcare community and consumers alike are recognizing the value of these beneficial microorganisms. However, because most probiotics are classified as dietary supplements, directing patients to the best probiotic for their individual needs can be challenging.

18 Nov 2011

IRCI to design and fund clinical trials for rare cancers

Cancer Research UK will join forces with international research groups from the UK, Europe and the US to launch an initiative to boost the development of new treatments for patients with rare cancers. The announcement will be made by Dr Harpal Kumar, chief executive of Cancer Research UK, at the 2011 World Cancer Leaders' Summit taking place today in Dublin.

18 Nov 2011

Study demonstrates how DISC1 variants affect brain development

Significant progress has been made in understanding the genetic risk factors underlying psychiatric disease. Recent studies have identified common genetic mutations conferring modest risk and rare variants comprising significant risk. One example of a rare cause of psychiatric disorders is the Disrupted in Schizophrenia-1 (DISC1) gene, first identified in a large Scottish pedigree displaying schizophrenia, bipolar disorder and depression.

18 Nov 2011

New framework to improve care for patients with delirium

A new national plan of action provides a roadmap for improving the care of patients with delirium, a poorly understood and often unrecognized brain condition that affects approximately seven million hospitalized Americans each year.

18 Nov 2011