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Landmark trial shows drug-eluting balloon as effective option for in-stent restenosis

Results from the first randomized clinical trial in the United States to compare a sirolimus-eluting balloon (DEB) to control group consisting of drug-eluting stent (DES) and balloon angioplasty (BA) for the treatment of bare-metal and DES in-stent restenosis (ISR) deemed DEB to be noninferior to conventional therapies.

28 Oct 2025

Cutting balloon angioplasty proves noninferior to intravascular lithotripsy in treating calcified coronary lesions

Results from the first randomized controlled trial to directly compare the safety and efficacy of cutting balloon (CB) angioplasty to intravascular lithotripsy (IVL) prior to drug-eluting stent (DES) implantation for the treatment of calcified coronary artery disease found CB to be noninferior to IVL.

28 Oct 2025

Mount Sinai receives $4.5 million grant to investigate neural mechanisms underlying bipolar disorder

The Icahn School of Medicine at Mount Sinai is pleased to announce it has received a three-year, $4.5 million grant from BD2: Breakthrough Discoveries for thriving with Bipolar Disorder to investigate the neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.

28 Oct 2025

Reducing prescriptions of sleep drugs in older adults could provide health and economic benefits

Millions of older Americans suffering from insomnia regularly use prescription sleep medications, despite the risk of serious side effects-such as falls, broken bones

28 Oct 2025

Circadian rhythm disruptions may increase the risk of cardiovascular disease

As modern lifestyles increasingly challenge the body's natural circadian rhythm, the American Heart Association is spotlighting the potential health consequences of regular disruptions to our body's internal clock with a new scientific statement published today in its flagship journal Circulation.

28 Oct 2025

Subtle brain changes in football players could predict the risk of chronic traumatic encephalopathy

Brain scans from American football players reveal subtle differences in the brain's outer grooves when compared to scans from otherwise healthy men who never played contact or collision sports, a new study shows.

28 Oct 2025

BD² expands global effort to examine the key mechanisms of bipolar disorder

Today, BD², or Breakthrough Discoveries for thriving with Bipolar Disorder, announced its third round of Discovery Research grants, totaling nearly $18 million – expanding a comprehensive global effort to examine the key mechanisms of bipolar disorder.

28 Oct 2025

Liver cirrhosis found to be more common in low-income households

Liver cirrhosis is significantly more common in low-income households than in high-income households. This is the result of a national study which, according to the researchers, calls for more preventive action in the most vulnerable groups.

28 Oct 2025

New drug can have a promising effect in cancer patients with active brain metastases

An international clinical study led by the Medical University of Vienna shows that the drug patritumab deruxtecan (HER3-DXd) can have a promising effect in patients with active brain metastases of various tumor types.

28 Oct 2025

Electronic health record data reveals trends in cardiovascular diseases before and after COVID-19

The electronic health record data analyzed in this study is anonymized and never leaves a secure data environment, which is only accessible by approved researchers working on approved projects.

28 Oct 2025

Scripps Research wins $4 million CIRM grant to develop novel platform for neurodevelopmental disorders

Most people are born with two functioning copies of each gene-one inherited from each parent. In many cases, having just one working copy is enough for the body to function normally.

28 Oct 2025

Air pollution, even below EPA guidelines, increases breast cancer risk

Women living in parts of the United States with lower air quality, especially neighborhoods with heavy emissions from motor vehicles, are more likely to develop breast cancer, according to a multiyear analysis involving more than 400,000 women and 28,000 breast cancer cases.

28 Oct 2025

Clinically significant valvular heart disease vastly underdiagnosed in U.S. elders

Results from the PREVUE-VALVE study suggest that there are currently at least 4.7 million people aged 65-85 living with moderate or greater valvular heart disease (VHD) in the United States, and at least 10.6 million with clinically significant VHD, most of whom are unaware of their condition.

28 Oct 2025

Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

Study reveals that group B [FeFe]-hydrogenase is the primary enzyme driving fermentative hydrogen production in the healthy human gut, mainly through Bacteroides species. These genes are significantly depleted in Crohn’s disease, indicating a metabolic shift and altered hydrogen cycling dominated by respiratory bacteria

27 Oct 2025

Obesity’s health risks shift with age and sex, new genetic study reveals

Using a new time-resolved Mendelian randomization approach in over 360,000 UK Biobank participants, Karlsson et al. revealed that the causal impact of obesity changes across life, with distinct age- and sex-specific risk patterns for diabetes, heart disease, atrial fibrillation, and osteoarthritis.

27 Oct 2025

Can cheese help prevent dementia? Japanese researchers say it might

Older Japanese adults who ate cheese at least once a week had a 21–24% lower risk of developing dementia over three years. The association remained significant even after adjusting for lifestyle and socioeconomic factors, suggesting a modest but meaningful protective effect.

27 Oct 2025

Fogarty Innovation and CRF unite to accelerate breakthroughs in cardiovascular medicine

After several years of close collaboration and a relationship rooted in mutual respect and shared vision, Fogarty Innovation is coming together with the Cardiovascular Research Foundation® (CRF®) to create a unified platform for advancing transformative healthcare technologies.

27 Oct 2025

Sirolimus-eluting balloon strategy matches drug-eluting stents in large international PCI trial

New study results from a large international all-comer population of percutaneous coronary intervention (PCI) candidates found that utilizing a strategy of sirolimus-eluting balloons with bailout stenting only if necessary was noninferior to routine drug-eluting stent (DES) implantation as part of the treatment for de novo coronary artery disease.

27 Oct 2025

Liver transplants from MAiD donors show outcomes comparable to standard donations

Organ donation following medical assistance in dying (MAiD), also known as euthanasia, is a relatively new practice both in North America and worldwide.

27 Oct 2025

Breakthrough study identifies potential treatment for schizophrenia symptoms

Difficulty completing everyday tasks. Failing memory. Unusually poor concentration.

27 Oct 2025

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Medical Condition News

Landmark trial shows drug-eluting balloon as effective option for in-stent restenosis

Cutting balloon angioplasty proves noninferior to intravascular lithotripsy in treating calcified coronary lesions

Mount Sinai receives $4.5 million grant to investigate neural mechanisms underlying bipolar disorder

Reducing prescriptions of sleep drugs in older adults could provide health and economic benefits

Circadian rhythm disruptions may increase the risk of cardiovascular disease

Subtle brain changes in football players could predict the risk of chronic traumatic encephalopathy

BD² expands global effort to examine the key mechanisms of bipolar disorder

Liver cirrhosis found to be more common in low-income households

New drug can have a promising effect in cancer patients with active brain metastases

Electronic health record data reveals trends in cardiovascular diseases before and after COVID-19

Scripps Research wins $4 million CIRM grant to develop novel platform for neurodevelopmental disorders

Air pollution, even below EPA guidelines, increases breast cancer risk

Clinically significant valvular heart disease vastly underdiagnosed in U.S. elders

Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

Obesity’s health risks shift with age and sex, new genetic study reveals

Can cheese help prevent dementia? Japanese researchers say it might

Fogarty Innovation and CRF unite to accelerate breakthroughs in cardiovascular medicine

Sirolimus-eluting balloon strategy matches drug-eluting stents in large international PCI trial

Liver transplants from MAiD donors show outcomes comparable to standard donations

Breakthrough study identifies potential treatment for schizophrenia symptoms

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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