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Science’s Breakthrough of the Year: GLP-1 agonists can blunt obesity-associated health problems

Science has named the development of glucagon like peptide-1 (GLP-1) agonists and this year's discovery that these drugs can blunt obesity-associated health problems as its 2023 Breakthrough of The Year.

15 Dec 2023

RNA-seq analysis reveals key factors in intervertebral disc degeneration

In a rapid communication published in the journal Genes & Diseases, researchers from Chongqing Medical University and Yongchuan Traditional Chinese Medicine Hospital of Chongqing have unveiled crucial insights into the factors that might influence Intervertebral Disc Degeneration (IDD).

15 Dec 2023

Wnt signaling holds promise for tailored immunotherapy in microsatellite-instable colorectal cancer

Colorectal cancer presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10%-15% of CRC cases, indicates a different clinical trajectory than microsatellite stable (MSS) patients.

15 Dec 2023

Alzheimer's may worsen COVID-19 outcomes via olfactory mucosa changes

A new study identifies alterations in the transcriptomic signatures in human olfactory mucosal cells of individuals with Alzheimer's disease following SARS-CoV-2 infection, potentially contributing to exacerbated COVID-19 outcomes.

15 Dec 2023

New LMU-led DFG Research Unit eyes innovative gene therapies for retinal diseases

A new LMU-led DFG Research Unit is developing innovative approaches for treating retinal diseases.

15 Dec 2023

Blueprint Medicines announces approval of AYVAKYT for treatment of ISM patients in Europe

Blueprint Medicines Corporation today announced the European Commission has approved AYVAKYT® (avapritinib) for the treatment of adult patients with indolent systemic mastocytosis (ISM) with moderate to severe symptoms inadequately controlled on symptomatic treatment. AYVAKYT is the first and only approved therapy for people living with ISM in Europe.

15 Dec 2023

UCL researchers develop new gene therapy to cure severe childhood epilepsy

UCL researchers have developed a new gene therapy to cure a devastating form of childhood epilepsy, which a new study shows can significantly reduce seizures in mice.

14 Dec 2023

Fetal hormone GDF15 linked to nausea and vomiting in pregnancy

Study finds that high levels of the fetal hormone GDF15 in mothers are linked to an increased risk of nausea, vomiting, and hyperemesis gravidarum in pregnancy, offering new insights into the condition's etiology.

14 Dec 2023

UH researchers secure NIH grant to tackle buprenorphine's dental side effects

In the fatal world of opioid use disorder (OUD), pharmacotherapy, or using a prescribed medication to treat drug dependence, has emerged as the gold standard of treatment.

14 Dec 2023

Researchers report progress in the search for more accurate blood markers for acute kidney injury

Using cells from kidney biopsies, Johns Hopkins Medicine, researchers report progress in the search for more accurate and easier-to-obtain markers to help predict, manage and assess treatment of acute kidney injury (AKI).

14 Dec 2023

Can community pharmacists reduce the incidence of skin cancer?

Study explores the impact of community pharmacists in skin cancer prevention, finding that their counseling significantly influences sunscreen purchases and dermatological visits.

14 Dec 2023

Overweight, not just obesity, drives higher healthcare costs, Norwegian study finds

A study at NTNU shows that while individual healthcare costs are highest for obese individuals, the overall societal costs are greater for the larger number of overweight people, highlighting the need for population-level health measures.

14 Dec 2023

Uncovering barriers to heart failure medication access for low-income patients

People who live in neighborhoods with higher levels of poverty and unemployment are less likely to fill their heart-failure drug prescriptions than those living in wealthier areas, a new study shows.

14 Dec 2023

Researchers identify the culprit responsible for harmful inflammation in certain muscular disorders

Inflammation is an important part of the body's defenses, eliminating threats and repairing damage. When the immune system is overactivated, though, it can turn from friend to foe.

14 Dec 2023

New advance in the development of a test for early diagnosis of cancer

Blood cells reveal tumors in the body. Researchers at the Paul Scherrer Institute achieve an advance with the development of a test for early diagnosis of cancer.

14 Dec 2023

Atezolizumab plus carboplatin: A winning combination for metastatic triple-negative breast cancer

Immunotherapy in combination with chemotherapy has become an important therapeutic treatment option in some patients with metastatic breast cancer.

14 Dec 2023

Common oral anticoagulant rivaroxaban linked to highest risk of bleeding complications

When diagnosed with a blood clot or atrial fibrillation, patients are often prescribed anticoagulants, or blood thinners, to prevent a future clot.

14 Dec 2023

The impact of racism on mental health disparities experienced by Black people in the United States

A series of literature reviews published online December 13 in The Lancet Psychiatry journal highlight the large body of evidence on the role played by racism in mental health disparities experienced by Black people living in the United States.

14 Dec 2023

Childhood sedentariness may be a key factor in elevated cholesterol and premature heart disease

Children who are physically inactive may have high cholesterol in early adulthood and subsequent heart health issues in their mid-forties, according to new research published in The Journal of Clinical Endocrinology & Metabolism.

14 Dec 2023

Researchers unveil new way to sensitize resistant tumors to treatment

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death.

14 Dec 2023

Medical Condition News

Science’s Breakthrough of the Year: GLP-1 agonists can blunt obesity-associated health problems

RNA-seq analysis reveals key factors in intervertebral disc degeneration

Wnt signaling holds promise for tailored immunotherapy in microsatellite-instable colorectal cancer

Alzheimer's may worsen COVID-19 outcomes via olfactory mucosa changes

New LMU-led DFG Research Unit eyes innovative gene therapies for retinal diseases

Blueprint Medicines announces approval of AYVAKYT for treatment of ISM patients in Europe

UCL researchers develop new gene therapy to cure severe childhood epilepsy

Fetal hormone GDF15 linked to nausea and vomiting in pregnancy

UH researchers secure NIH grant to tackle buprenorphine's dental side effects

Researchers report progress in the search for more accurate blood markers for acute kidney injury

Can community pharmacists reduce the incidence of skin cancer?

Overweight, not just obesity, drives higher healthcare costs, Norwegian study finds

Uncovering barriers to heart failure medication access for low-income patients

Researchers identify the culprit responsible for harmful inflammation in certain muscular disorders

New advance in the development of a test for early diagnosis of cancer

Atezolizumab plus carboplatin: A winning combination for metastatic triple-negative breast cancer

Common oral anticoagulant rivaroxaban linked to highest risk of bleeding complications

The impact of racism on mental health disparities experienced by Black people in the United States

Childhood sedentariness may be a key factor in elevated cholesterol and premature heart disease

Researchers unveil new way to sensitize resistant tumors to treatment

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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