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Combining a chemical blocker of immune cell exit with immunotherapy stops skin cancer growth

The number of specialized immune cells available for fighting skin cancer doubled when a new treatment blocked their escape from melanoma tumors, experiments in mice and human cells show.

27 Feb 2023

Researchers explore potential new target for cancer immunotherapy

A new study posted to the bioRxiv* preprint server, focused on the role of YAP in regulating MHC-I APM expression within tumor cells.

27 Feb 2023

Study: Half of adverse pregnancy outcomes occur in individuals without any heart disease risk factors

Many pregnancy complications are associated with future heart disease. Such complications include gestational diabetes, preterm birth, fetal growth restriction and hypertensive disorders of pregnancy (gestational hypertension, preeclampsia and related disorders), and together they are referred to as adverse pregnancy outcomes (APOs).

27 Feb 2023

Using sweat to diagnosis disease: soft microfluidic analysis systems assess health status

Researchers explored microfluidic systems with a skin interface in assessing chemical exposure and health status.

27 Feb 2023

Can the gut microbiota and metabolome explain variation in anti-SARS-CoV-2 vaccination responses in immunosuppressed IBD patients?

Researchers explored the connection between the metabolic function of the gut microbiota, its composition, and immune response to SARS-CoV-2 vaccination in IBD patients.

27 Feb 2023

The natural history of tau accumulation and the impact of disease stage and reference region on the magnitude and effect size of regional change

Researchers performed serial tau imaging with 18F-MK6240 to detect tau accumulation in cognitively unimpaired beta-amyloid negative Alzheimer’s disease patients as well as those with mild cognitive impairment who were Aβ+ at baseline.

27 Feb 2023

Does a negative COVID-19 test before air travel reduce the spread of COVID-19 transmission during and after travel?

Researchers assessed the impact of pre-departure testing on SARS-CoV-2-positivity rates post-arrival among international travelers.

27 Feb 2023

What is the effect of maternal circulating amino acids on offspring birthweight?

Researchers examined the effect of serum levels of 20 amino acids in a mother during pregnancy on offspring birthweight in a two-sample summary data Mendelian randomization framework.

27 Feb 2023

Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall

Researchers assessed T-cell tolerance checkpoints observed in atherosclerosis.

27 Feb 2023

High-dose ivermectin does not reduce COVID-19 symptom duration among mild-to-moderate outpatients

Researchers evaluate the efficacy of ivermectin in a maximum dosage of 600 μg/kg/day over six days in treating early mild-to-moderate COVID-19.

27 Feb 2023

Study shows COVID-19 rates were likely forty-times higher than CDC estimates during BA.4/BA.5 dominant period in the U.S.

Researchers evaluate the prevalence of SARS-CoV-2 infections and the incidence of long COVID during BA.4/BA.5 dominant period.

27 Feb 2023

Rebounding of COVID-19 symptoms and viral load are common among untreated COVID-19 patients

Researchers characterize COVID-19 symptom and viral load rebounds among untreated individuals with mild-to-moderate SARS-CoV-2 infection.

27 Feb 2023

Study findings contradict prevailing wisdom on obesity and mortality risk

Excess weight or obesity boosts risk of death by anywhere from 22% to 91% - significantly more than previously believed - while the mortality risk of being slightly underweight has likely been overestimated, according to new CU Boulder research.

27 Feb 2023

Determining the role of the epigenetic enzyme, HDAC5, in an animal model

Substance use disorder (SUD) is an extremely difficult disorder to overcome, and many individuals with SUD return to regular use after repeated attempts to quit.

27 Feb 2023

High throughput device isolates and classifies metabolically active CTCs

Researchers from the University of Technology Sydney have developed a new device that can detect and analyze cancer cells from blood samples, enabling doctors to avoid invasive biopsy surgeries, and to monitor treatment progress.

27 Feb 2023

Experts develop commercial formulation Campto for colorectal cancer

Announcing a new publication for Acta Materia Medica journal. The compound 7-ethyl-10-hydroxy-camptothecin (SN38) is a broad-spectrum antitumor agent whose applications are greatly limited by its poor solubility. Therefore, irinotecan, the hydrophilic derived prodrug of SN38, has been developed as the commercial formulation Campto® for colorectal cancer.

25 Feb 2023

Viable treatment option for patients with advanced cervical cancer

A recent University of Kentucky Markey Cancer Center study suggests a new radiopharmaceutical compound may be a viable treatment option for patients with advanced cervical cancer.

25 Feb 2023

Cedars-Sinai addresses life-threatening aorta condition

Her husband and their five children call Rosa Wernher "the Energizer bunny" because she is always on the go. For decades, not even her genetically inherited Marfan syndrome could keep her off her feet to prevent her from oil painting or from gliding down a ski slope--until it did.

25 Feb 2023

Novel microfluidic model mimics a rare genetic disorder

Our bodies are made up of 60,000 miles of complex pipes that play a vital role in transporting nutrients throughout our bodies, performing waste disposal, and supplying our organs with fresh oxygen and blood.

24 Feb 2023

Women with a BRCA1 or BRCA2 pathogenic variant have high risk of cancer after age 50

Although genetic mutations in BRCA1 or BRCA2 are associated with a younger onset of breast and ovarian cancer, women with these genetic mutations continue to face a high risk of cancer incidence after age 50, even if they have not been previously diagnosed with cancer.

24 Feb 2023

Medical Research News

Combining a chemical blocker of immune cell exit with immunotherapy stops skin cancer growth

Researchers explore potential new target for cancer immunotherapy

Study: Half of adverse pregnancy outcomes occur in individuals without any heart disease risk factors

Using sweat to diagnosis disease: soft microfluidic analysis systems assess health status

Can the gut microbiota and metabolome explain variation in anti-SARS-CoV-2 vaccination responses in immunosuppressed IBD patients?

The natural history of tau accumulation and the impact of disease stage and reference region on the magnitude and effect size of regional change

Does a negative COVID-19 test before air travel reduce the spread of COVID-19 transmission during and after travel?

What is the effect of maternal circulating amino acids on offspring birthweight?

Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall

High-dose ivermectin does not reduce COVID-19 symptom duration among mild-to-moderate outpatients

Study shows COVID-19 rates were likely forty-times higher than CDC estimates during BA.4/BA.5 dominant period in the U.S.

Rebounding of COVID-19 symptoms and viral load are common among untreated COVID-19 patients

Study findings contradict prevailing wisdom on obesity and mortality risk

Determining the role of the epigenetic enzyme, HDAC5, in an animal model

High throughput device isolates and classifies metabolically active CTCs

Experts develop commercial formulation Campto for colorectal cancer

Viable treatment option for patients with advanced cervical cancer

Cedars-Sinai addresses life-threatening aorta condition

Novel microfluidic model mimics a rare genetic disorder

Women with a BRCA1 or BRCA2 pathogenic variant have high risk of cancer after age 50

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

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