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What is the immune protection generated by SARS-CoV-2 Delta and Omicron BA.1 and BA.2 against Omicron BA.4 and BA.5?

Researchers evaluated immune protection conferred by previous SARS-CoV-2 Delta variant and Omicron BA.1/BA.2 subvariant infections and updated vaccines against Omicron BA.4/5 infections and associated hospitalizations.

17 Nov 2022

Evaluating differences in viral and symptom rebounds between Paxlovid-treated and untreated COVID-19 patients

Researchers evaluated differences in viral and symptom rebounds between Paxlovid-treated and untreated coronavirus disease 2019 (COVID-19) patients.

17 Nov 2022

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Researchers examined the prevalence of contraindications to nirmatrelvir-ritonavir (Paxlovid) in hospitalized coronavirus disease 2019 (COVID-19) patients.

17 Nov 2022

Study describes distinct pattern of ongoing respiratory syncytial virus transmission in the Netherlands after the COVID-19 pandemic

Researchers assessed respiratory syncytial virus (RSV) transmission after the coronavirus disease 2019 (COVID-19) pandemic in the Netherlands.

17 Nov 2022

Comparing post–COVID-19 symptoms two years after SARS-CoV-2 infection

Researchers compared the presence of post–coronavirus disease 2019 (COVID-19) symptoms among hospitalized and non-hospitalized patients in Spain.

17 Nov 2022

New therapeutic windows for developing effective treatments for metastatic tumors

Cancer that splits and develops in new organs around the body becomes significantly more difficult to fight. Now, researchers at Chalmers University of Technology, Sweden, have shown that these metastatic cancers, that spread from the original, adapt their metabolism to the tissue in which they grow. The discovery represents a breakthrough for the understanding of metastatic cancer and is an important piece of the puzzle in the search for more effective treatments.

17 Nov 2022

Scientific gathering aims to integrate advances in cancer and aging research

Institute for Research in Biomedicine - IRB Ageing is the main risk factor for the development of cancer, and the features shared by these two biological processes are increasingly evident. This week the Institute for Research in Biomedicine (IRB Barcelona) and the BBVA Foundation are holding the 38th Barcelona Biomed conference "Quantitative dynamics of aging and premalignancy". Held at the Sant Pau Art Nouveau Site on 14, 15 and 16 November, the event will be hosting 21 internationally recognized experts in the field who will present their latest breakthroughs.

17 Nov 2022

Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden

Researchers from Sweden conducted a cohort study to evaluate the protection granted by previous SARS-CoV-2 Omicron subvariant infections against reinfections among individuals vaccinated between June and August 2022.

17 Nov 2022

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Researchers presented a functional analysis of the SARS-CoV-2 open reading frame 3c (ORF3c) protein.

17 Nov 2022

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Researchers validated monkeypox virus (MPXV) quantitative polymerase chain reaction (qPCR) assays.

17 Nov 2022

Artificial neural network creates synthetic x-ray images to overcome regulatory limitations

Sharing medical data between laboratories and medical experts is important for medical research. However, data sharing is often sufficiently complex and sometimes even impossible due to the strict data regulatory legislation in Europe. Researchers at the University of Jyväskylä Digital Health Intelligence Laboratory addressed the problem and developed an artificial neural network that creates synthetic x-ray images that can fool even medical experts.

17 Nov 2022

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

Researchers explored the efficiency of a macrocyclic peptide in inhibiting the SARS-CoV-2 spike protein.

17 Nov 2022

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.

17 Nov 2022

When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people?

Researchers evaluated dose-sparing strategies for monkeypox (MPX) vaccination using mathematical modeling.

17 Nov 2022

Study uncovers new rules for lineage progression

The hypothalamus, one of the most complex brain regions in the mammalian nervous system, contains an astonishing heterogeneity of neurons that regulate endocrine, autonomic and behavioral functions. It not only regulates food consumption, water intake, body temperature, circadian rhythm and sleep to maintain the survival of individual organisms, but also controls puberty onset and reproductive behavior to sustain the breeding population.

17 Nov 2022

Potential effects of nonoral versus oral gender-affirming estrogen therapy

A comprehensive review of research into the delivery method of estrogen treatment (e.g., oral, intramuscular injection, transdermal patch, etc.) and cardiovascular risk in transgender women and gender-diverse people found that treatment route may affect heart health, but there is not enough available data for metanalysis. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for November.

17 Nov 2022

National Institutes of Health funds a five-year, $11 million initiative

The conversations between our bone and muscle change as we age, and both are the weaker for it, Medical College of Georgia scientists say.

17 Nov 2022

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues unharmed. Scientists have dubbed this type of targeted approach a "prodrug" - a medicine designed to release its payload in a particular area of the body and in no other areas.

17 Nov 2022

Research highlights an understudied aspect of Alzheimer’s disease

Memory loss is often the first sign of Alzheimer's disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of worsening damage to brain tissues. Toxic clusters of proteins first concentrate in the temporal lobes of the brain - the memory area - before spreading to parts of the brain important for thinking and planning.

17 Nov 2022

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.

17 Nov 2022

Medical Research News

What is the immune protection generated by SARS-CoV-2 Delta and Omicron BA.1 and BA.2 against Omicron BA.4 and BA.5?

Evaluating differences in viral and symptom rebounds between Paxlovid-treated and untreated COVID-19 patients

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Study describes distinct pattern of ongoing respiratory syncytial virus transmission in the Netherlands after the COVID-19 pandemic

Comparing post–COVID-19 symptoms two years after SARS-CoV-2 infection

New therapeutic windows for developing effective treatments for metastatic tumors

Scientific gathering aims to integrate advances in cancer and aging research

Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Artificial neural network creates synthetic x-ray images to overcome regulatory limitations

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people?

Study uncovers new rules for lineage progression

Potential effects of nonoral versus oral gender-affirming estrogen therapy

National Institutes of Health funds a five-year, $11 million initiative

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Research highlights an understudied aspect of Alzheimer’s disease

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

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