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Researchers use urine test to identify and verify a patient's type of asthma

In a new study, researchers at Karolinska Institutet in Sweden have used a urine test to identify and verify a patient's type of asthma.

13 Jan 2021

Could fenofibrate be an effective antiviral against SARS-CoV-2?

The resurgence of COVID-19 pandemic, caused by the SARS-CoV-2, has led to renewed efforts to find effective antivirals, both newly developed or repurposed drugs. A study reports the efficacy of the cholesterol-reducing drug fenofibrate in reducing infection rates of SARS-CoV-2 in cultured cells.

13 Jan 2021

Researchers assess medical practice patterns of primary care physicians

Harmful medical practices, like inappropriate prescribing of opioids and racial and income-based discrimination in clinical settings, can vary across medical practices and individuals.

13 Jan 2021

New technology could protect against different coronavirus variants

The SARS-CoV-2 virus that is causing the COVID-19 pandemic is just one of many different viruses in the coronavirus family.

13 Jan 2021

Scientists identify bacteria-based approach against cancer

The body's immune system is the first line of defense against infections like bacteria, viruses or cancers. Some cancers, however, have developed the art of molecular deception to avoid destruction by the body's immune system.

13 Jan 2021

Researchers develop novel antibody fragments against SARS coronavirus-2

An international research team led by the University of Bonn (Germany) has identified and further developed novel antibody fragments against the SARS coronavirus-2. These "nanobodies" are much smaller than the classic antibodies used to treat US President Donald Trump, for example.

13 Jan 2021

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

DiosCURE SE announced a publication in Science describing its core technology of multivalent single-chain antibodies with a unique molecular mode-of-action to inactivate SARS-CoV-2 virions. An international team led by scientists at the University of Bonn developed and characterized the lead candidates, which are exclusively licensed by DiosCURE.

13 Jan 2021

Study shows how neurons can become a target of SARS-CoV-2 infection

Using both mouse and human brain tissue, researchers at Yale School of Medicine have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus's effects on brain cells.

13 Jan 2021

Cardiovascular deaths unrelated to COVID-19 increased during the pandemic, study finds

As the number of COVID-19 infections continues to rise nationwide, more than 360,000 Americans have already died from the potentially deadly viral infection.

13 Jan 2021

Study: Testing policies should vary based on demand to catch the most COVID-19 cases

With months to go in the mass rollout of COVID-19 vaccines, testing is still critical to control the surging pandemic.

13 Jan 2021

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

A short paper that appeared recently on the preprint bioRxiv server pointed to a link between specific characteristics of anti-SARS-CoV-2 antibodies associated with the severity of COVID-19.

12 Jan 2021

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

A new preprint that appeared on the bioRxiv server reports that intranasal vaccination with the D614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus monkeys reduces viral shedding. This is an experiment in non-human primates (NHP), and its extrapolation to humans is unclear as yet.

12 Jan 2021

Structure of SARS-CoV-2 cytoplasmic tail uncovered

The virus's cytosolic tail also interacts with the host cell to promote its entry into the endoplasmic reticulum (ER). A new study appearing on the bioRxiv preprint server elucidates the conformation of this region of the virus, which will help understand how its form is related to its function in viral entry.

12 Jan 2021

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization.

12 Jan 2021

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the pathogen responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Approximately 20-55% of hospitalized COVID-19 patients are reported to have deranged hemostatic laboratory parameters, which suggests coagulopathy.

12 Jan 2021

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Reprogramming the rich connective tissue microenvironment of a liver cancer known as intrahepatic cholangiocarcinoma (ICC) inhibits its progression and resistance to standard chemotherapy in animal models, researchers from Massachusetts General Hospital have found.

12 Jan 2021

Mothers with multiple children report worse sleep patterns

Mothers with multiple children report more fragmented sleep than mothers of a single child, but the number of children in a family doesn't seem to affect the quality of sleep for fathers, according to a study from McGill University.

12 Jan 2021

Antigenic "supersite" could improve design of COVID-19 vaccines

Researchers in the United States have defined an antigenic “supersite” within the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could have important implications for the design of vaccines to protect against coronavirus disease 2019 (COVID-19).

12 Jan 2021

Study reveals rising risk of mental health problems among COVID-19 health care professionals

The daily toll of COVID-19, as measured by new cases and the growing number of deaths, overlooks a shadowy set of casualties: the rising risk of mental health problems among health care professionals working on the frontlines of the pandemic.

12 Jan 2021

Study investigates the metabolites involved in growth and spread of melanoma

The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact.

12 Jan 2021