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Study: Anal intraepithelial neoplasia is a precursor lesion for anal squamous cell carcinomas

Oncotarget recently published "PD-1/PD-L1 expression in anal squamous intraepithelial lesions" which reported that the presence and distribution of CD8 lymphocytes and the presence of PD-1 lymphocytes and PD-L1 epithelial cells were assessed.

12 Jan 2021

ADC histogram analysis can predict tumor proliferation, survival in immunocompetent patients with PCNSL

The cover for issue 45 of Oncotarget features Figure 3, "Representative images of whole tumor volume segmentation of the co-registered T1 post-contrast sequence and apparent diffusion coefficient (ADC) map, yielding the corresponding ADC histogram distribution utilized for data analysis," recently published in "Diffusion-weighted MR imaging histogram analysis in HIV positive and negative patients with primary central nervous system lymphoma as a predictor of outcome and tumor proliferation" by Khan, et al.

12 Jan 2021

Insulin nanoparticles may become an alternative to insulin injections for diabetic patients

Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed insulin nanoparticles that may one day become the basis for an oral medicine, and an alternative to insulin injections for diabetic patients.

12 Jan 2021

Wearable heart monitors and deep learning can provide early warning of SARS-CoV-2 infection

A recent study, appearing as a preprint on the medRxiv* server, reveals the possibility of early prediction of SARS-CoV-2 infection using data on the resting heart rate in the presymptomatic period.

12 Jan 2021

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

A shadow over the promising inhaled interferon beta COVID-19 therapy has been cleared with the discovery that although it appears to increase levels of ACE2 protein - coronavirus' key entry point into nose and lung cells - it predominantly increases levels of a short version of that protein, which the virus cannot bind to.

12 Jan 2021

ARID1A gene in ovarian cancer plays a role in the regulation of metabolism

Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute published online in Nature Cancer.

12 Jan 2021

Study shows COVID-19 pneumonia is different from typical pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung over the course of hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body's immune system within the first few days of the illness.

12 Jan 2021

Researchers study the behavior of regulatory T cells to understand periodontal disease

In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone?

12 Jan 2021

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Now, a new preprint research paper published on the bioRxiv server shows how closely the antibodies formed in exposed humans resemble the germline antibody molecules. This could lead to the development of novel therapeutics to counter the pandemic.

12 Jan 2021

Study could help develop new oral drugs for treating muscular dystrophy, heart failure

Cell-derived exosomes are effective in treating disease when mixed with the dominant protein in breast milk and given orally, a new Smidt Heart Institute study of laboratory mice shows.

12 Jan 2021

Researchers identify a new link between seizures and connexin 36 deficiency

For the brain to learn, retain memories, process sensory information, and coordinate body movements, its groups of nerve cells must generate coordinated electrical signals. Disorder in synchronous firing can impair these processes and, in extreme cases, lead to seizures and epilepsy.

12 Jan 2021

Patient with hypertension or cardiovascular diseases experienced critical disease progression with COVID-19

COVID-19 patients who also suffer from high blood pressure are more likely to fall severely ill with the disease, which also leaves them at greater risk of death.

11 Jan 2021

COVID-19 taking a disproportionate toll on female healthcare workers

Women in the healthcare workforce seem to be suffering stress and burnout in the current pandemic situation, disproportionately when compared to men, suggests a new preprint research paper published on the medRxiv server.

11 Jan 2021

Mosaic mutations during embryonic development can cause autism spectrum disorder

Two studies in today's Nature Neuroscience, led by researchers at Boston Children's Hospital, Brigham and Women's Hospital (BWH), and Harvard Medical School (HMS), implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The findings open new areas for exploring the genetics of ASD and could eventually inform diagnostic testing.

11 Jan 2021

SARS-CoV-2 exposure in England could be double reported seroprevalence

A new study that recently appeared on the preprint server medRxiv* makes use of a combined method to estimate population exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), taking into account the fact that patients who recover from the infection often do not have circulating antibodies against the virus.

11 Jan 2021

The mystery of Giglio island’s resistance to COVID-19

An intriguing new study explores the mechanisms by which an Italian island called Giglio remained resistant to coronavirus disease 2019 (COVID-19) even after much exposure.

11 Jan 2021

Study supports continuing phase 3 trials of Ad26.COV2.S SARS-CoV-2 vaccine

An international team of researchers has provided further evidence to confirm the immunogenicity and efficacy of a recombinant adenovirus vaccine currently being tested in phase 3 trials for its ability to protect against infection with severe acute respiratory coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

11 Jan 2021

UMass Lowell researcher receives NIH support to develop therapies for young people with TBIs

A UMass Lowell researcher developing innovative therapies for injured children and teens has received more than $700,000 from the National Institutes of Health to support that work.

11 Jan 2021

Study: Telehealth use jumped sharply during the first months of pandemic shutdown

Use of telehealth jumped sharply during the first months of the coronavirus pandemic shutdown, with the approach being used more often for behavioral health services than for medical care, according to a new RAND Corporation study.

11 Jan 2021

Extract of medicinal plant Artemisia annua interferes with replication of SARS-CoV-2 in vitro

Researchers in the United States have shown that extracts of an aromatic herb called Artemisia annua inhibit the replication of severe acute respiratory coronavirus (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

11 Jan 2021

Medical Research News

Study: Anal intraepithelial neoplasia is a precursor lesion for anal squamous cell carcinomas

ADC histogram analysis can predict tumor proliferation, survival in immunocompetent patients with PCNSL

Insulin nanoparticles may become an alternative to insulin injections for diabetic patients

Wearable heart monitors and deep learning can provide early warning of SARS-CoV-2 infection

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

ARID1A gene in ovarian cancer plays a role in the regulation of metabolism

Study shows COVID-19 pneumonia is different from typical pneumonia

Researchers study the behavior of regulatory T cells to understand periodontal disease

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Study could help develop new oral drugs for treating muscular dystrophy, heart failure

Researchers identify a new link between seizures and connexin 36 deficiency

Patient with hypertension or cardiovascular diseases experienced critical disease progression with COVID-19

COVID-19 taking a disproportionate toll on female healthcare workers

Mosaic mutations during embryonic development can cause autism spectrum disorder

SARS-CoV-2 exposure in England could be double reported seroprevalence

The mystery of Giglio island’s resistance to COVID-19

Study supports continuing phase 3 trials of Ad26.COV2.S SARS-CoV-2 vaccine

UMass Lowell researcher receives NIH support to develop therapies for young people with TBIs

Study: Telehealth use jumped sharply during the first months of pandemic shutdown

Extract of medicinal plant Artemisia annua interferes with replication of SARS-CoV-2 in vitro

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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