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Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Oncotarget recently published "Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer" which reported that the authors investigated whether Trop-2-expression and homologous recombination repair of SN-38-mediated double-strand DNA breaks play a role in the sensitivity of triple-negative breast cancer to SG.

3 Nov 2020

Researchers identify a novel vulnerability in advanced prostate cancer

Researchers at the University of Bern led an international team that has identified a novel vulnerability in advanced prostate cancer that is no longer responding to hormonal therapy.

3 Nov 2020

Infection prevention practices during COVID-19 result in shorter hospital stays for moms, babies

New infection prevention practices implemented during the coronavirus pandemic have resulted in significantly shorter hospital stays for mothers and their babies, according to investigators at Cedars-Sinai, with no changes in the rates of cesarean deliveries, complications or poor outcomes.

3 Nov 2020

Beta-blockers could be used to treat COVID-19, study finds

Beta-blockers could potentially be used to treat COVID-19, according to a new international study by Italian and Australian scientists.

3 Nov 2020

Novel molecules show potential for future cancer therapies

Cancers sometimes escape our immune defenses because of the over-activity of molecular signaling systems, called checkpoint processes. Now we may be able to fight back using a new range of molecules, researchers in China report in the European Journal of Medicinal Chemistry.

3 Nov 2020

New treatment method could be more effective for Alzheimer's disease

In Alzheimer's disease, a protein (peptide) forms clumps in the brain and causes sufferers to lose their memory. In a recently published article, a research group at Uppsala University described a new treatment method that increases the body's own degradation of the building blocks that lead to these protein clumps.

3 Nov 2020

Study estimates the proportion of COVID-19 deaths due to air pollution

Long-term exposure to air pollution generated by human activity is linked to about 27 per cent of COVID-19-related deaths in East Asia and 15 per cent mortality in South Asia and worldwide. These deaths could be largely prevented by adopting air quality regulations, says a new study.

3 Nov 2020

Study: Patients' abilities to see preferred GP have fallen greater in English practices

A new study published by the British Journal of General Practice has found that patients' abilities to see their preferred GP has fallen greater in English practices that have expanded, compared with those that stayed about the same size.

3 Nov 2020

New study may help improve walking capacity in people with multiple sclerosis

Significant gaps in how walking capacity and performance is assessed for people with Multiple Sclerosis (MS) could be harming therapy and treatment development according to McGill University researchers.

3 Nov 2020

Researchers use new approach to study the mechanisms of cellular uptake of amyloid beta

One of the hallmarks of Alzheimer's disease is the formation of amyloid plaques--sticky clumps of a protein called amyloid beta--that collect between neurons in the brain.

3 Nov 2020

Scientists explore relationship between moisture and disease establishment

Downy mildew is the biggest threat to spinach production around the world. While the pathogen has a short life cycle (approximately a week), it can produce millions of spores during the spinach growing season.

3 Nov 2020

Scientists identify neutralizing human monoclonal antibodies against SARS-CoV-2

University of Pittsburgh School of Medicine scientists have discovered the fastest way to identify potent, neutralizing human monoclonal antibodies against SARS-CoV-2, the virus that causes COVID-19.

3 Nov 2020

Clinical Decisions article documents three approaches to manage elective surgery during COVID-19

Tanira B.D. Ferreira, M.D., FCCP, chief medical officer of University of Miami Hospital and Clinics, was one of three authors featured in the New England Journal of Medicine for her expertise in how to manage elective surgeries during COVID-19 surges.

3 Nov 2020

Study shows how brain cells influence choices

When you are faced with a choice - say, whether to have ice cream or chocolate cake for dessert - sets of brain cells just above your eyes fire as you weigh your options.

3 Nov 2020

Researchers uncover molecular mechanisms involved in the formation of neural circuits

Scientists at Korea's Daegu Gyeongbuk Institute of Science and Technology (DGIST) and colleagues have uncovered some of the complex molecular mechanisms involved in the formation of the brain's neural circuits.

3 Nov 2020

New model uses people’s breathing rates to track virus-carrying droplets

How many virus particles you inhale and where they land within the respiratory tract can affect your chances of contracting COVID-19, according to assistant professor Saikat Basu of South Dakota State University's Department of Mechanical Engineering.

3 Nov 2020

Mobile dating applications are linked to depression, social anxiety

Depression symptoms and social anxiety are associated with greater use of mobile dating applications among women. The extent to which these are associated with dating app use is reported in the peer-reviewed journal Cyberpsychology, Behavior, and Social Networking.

3 Nov 2020