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Vaccine candidate targeting SARS-CoV-2 nucleocapsid protein elicits protective immune response in animal model

New preclinical results from a study led by David Masopust of the University of Minnesota in Minneapolis, USA, show that a Had5-based vaccine targeting the nucleocapsid protein can also elicit a protective immune response.

3 May 2021

Competitive multiplex binding assay can monitor SARS-CoV-2 immune responses using nanobodies

Researchers at the Eberhard Karls University and the University of Tübingen in Germany described 11 unique nanobodies (Nbs) specific for the SARS-CoV-2 spike receptor-binding domain (RBD), of which 8 Nbs potentially inhibit the connection of RBD with the angiotensin-converting enzyme 2 (ACE2).

3 May 2021

SARS-CoV-2’s distinctive "spike" protein plays a key role in the disease itself, shows study

Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself.

3 May 2021

New gene therapy restores dystrophin protein in patients with Duchenne muscular dystrophy

UT Southwestern scientists successfully employed a new type of gene therapy to treat mice with Duchenne muscular dystrophy (DMD), uniquely utilizing CRISPR-Cas9-based tools to restore a large section of the dystrophin protein that is missing in many DMD patients.

3 May 2021

Pulmonary endarterectomy improves outcomes in patients with segmental disease

A new study, presented today at the AATS 101st Annual Meeting, found that patients treated surgically for segmental Chronic Thromboembolic Pulmonary Hypertension (CTEPH) had excellent outcomes with the vast majority doing very well in the long term without any additional treatment other than surgery.

3 May 2021

Atrial fenestration during atrioventricular septal defect repair is linked to higher mortality rate

A new study, presented today at the AATS 101st Annual Meeting, shows an association between decreased survival at five years and leaving an atrial communication at biventricular repair of unbalanced AVSD after adjusting for other known risk factors.

3 May 2021

Study finds one-third of COVID-19 patients experience neurological symptoms

The research on the short and long-term effects of COVID-19 disease is ongoing. Still, scientists have found severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the brain causing loss of smell and taste, dizziness, muscle pain, fatigue, and other cognitive impairments. However, it remained unknown why certain people developed neurological symptoms while others did not.

3 May 2021

Majority of patients who needed surgery after failed TEER required mitral valve replacement

A new study, presented today at the AATS 101st Annual Meeting, and simultaneously published in the Journal of the American College of Cardiology, finds that patients suffering from severe mitral regurgitation should be carefully screened and counselled before undergoing transcatheter edge-to-edge mitral repair (TEER).

3 May 2021

Low-profile thoracic aortic endograft minimizes complications, increases patient pool

Preliminary results of a clinical trial, presented today at the AATS 101st Annual Meeting, showed that a new, low-profile thoracic aortic endograft is safe and effective in the treatment of descending thoracic aortic aneurysm or penetrating atherosclerotic ulcer (PAU) diseases.

3 May 2021

Study estimates true number of COVID-19 deaths by U.S. county

Every country has been affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has spawned a pandemic. For several factors, the United States has been hit hard by the number of coronavirus cases and death. The country currently leads the world with over 32.4 million infections and more than 577,000 COVID-19 deaths.

3 May 2021

Study quantifies the true incidence of venous thromboembolism post esophagectomy

A new study presented today at the AATS 101st Annual Meeting, found that the percentage of patients undergoing esophagectomy for cancer who suffer Venous Thromboembolism (VTE) post-operatively is much higher than previously reported, with as many as 24 percent suffering from Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE).

3 May 2021

New approach could revolutionize the treatment of liver diseases

Researchers from Niigata University , the University of Tokyo, Osaka University and Tokyo Medical University, Japan have developed a new approach that could revolutionize the treatment, prevention, and possibly reversal of the damages caused by liver diseases.

3 May 2021

Comprehensive "cell atlas" shows how COVID-19 can lead to organ failure and death

Scientists from several hospitals and research centers have shown what happens in individual cells of patients who died of COVID-19. In a study published in Nature, the researchers describe how infected cells from multiple organs exhibited a range of molecular and genomic changes.

3 May 2021

Interdisciplinary project explores the phenomenon of so-called “superspreaders”

Scientists from the Departments of Physics, Biomedical Sciences and Process Engineering at Otto von Guericke University Magdeburg are in the process of analyzing the emergence and spread of infectious air bubbles in our breath, known as aerosols, using tissue cultivations and artificially-produced, virus-filled suspended particles.

3 May 2021

Study reveals new broadly neutralizing and protective antibody against coronaviruses

In the setting of potentially reduced vaccine efficacy against coronavirus disease (COVID-19) due to emerging viral variants, the deployment of effective treatments based on monoclonal antibodies may be an additional strategy to help control the pandemic. A new study by US researchers, currently available on the bioRxiv* preprint server, describes the action of a specific antibody known as DH1047.

3 May 2021

Researchers identify novel SARS-CoV-2 variant with mutations in membrane protein-encoding gene

A recent study published in the Journal Emerging Microbes and Infections has highlighted the emergence of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant with mutations in the membrane protein-encoding gene. Two potential mutations, M:I82T and M:V70L, have been identified within the transmembrane helices, which are expected to improve viral fitness by modulating glucose uptake during replication.

3 May 2021

Researchers develop a nanoparticle-based formulation with anti-SARS-CoV-2 activity

A study recently published in the journal Matter has demonstrated the development and validation of a nanoparticle-based formulation, capable of completely inhibiting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection blocking the interaction between viral spike protein and host cell angiotensin-converting enzyme 2 (ACE2).

3 May 2021

Could CRISPR be used as a SARS-CoV-2 antiviral?

The potential of using this gene manipulation technology as a SARS-CoV-2 inhibitor or prophylactic is investigated in a review recently uploaded to the journal Experimental Biology and Medicine (April 25th, 2021) by Arnab Banerjee and colleagues.

2 May 2021

Study implies a likely rise of future SARS-CoV-2 recombinants

A recent astonishing feat by US researchers revealed that recombination is not only widespread in the evolutionary history of SARS-like coronaviruses, but it can also increase fitness traits of seasonal coronaviruses. Their paper is currently available on the bioRxiv* preprint server and sets the stage for phylogenetic tracking of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 May 2021

Live "attenuated" influenza virus vaccine protects animals against respiratory infections, including SARS-CoV-2

Researchers in the United States and Austria have demonstrated the potential of a modified influenza virus as a vaccine to protect against viral respiratory pathogens, including the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19).

2 May 2021

Medical Research News

Vaccine candidate targeting SARS-CoV-2 nucleocapsid protein elicits protective immune response in animal model

Competitive multiplex binding assay can monitor SARS-CoV-2 immune responses using nanobodies

SARS-CoV-2’s distinctive "spike" protein plays a key role in the disease itself, shows study

New gene therapy restores dystrophin protein in patients with Duchenne muscular dystrophy

Pulmonary endarterectomy improves outcomes in patients with segmental disease

Atrial fenestration during atrioventricular septal defect repair is linked to higher mortality rate

Study finds one-third of COVID-19 patients experience neurological symptoms

Majority of patients who needed surgery after failed TEER required mitral valve replacement

Low-profile thoracic aortic endograft minimizes complications, increases patient pool

Study estimates true number of COVID-19 deaths by U.S. county

Study quantifies the true incidence of venous thromboembolism post esophagectomy

New approach could revolutionize the treatment of liver diseases

Comprehensive "cell atlas" shows how COVID-19 can lead to organ failure and death

Interdisciplinary project explores the phenomenon of so-called “superspreaders”

Study reveals new broadly neutralizing and protective antibody against coronaviruses

Researchers identify novel SARS-CoV-2 variant with mutations in membrane protein-encoding gene

Researchers develop a nanoparticle-based formulation with anti-SARS-CoV-2 activity

Could CRISPR be used as a SARS-CoV-2 antiviral?

Study implies a likely rise of future SARS-CoV-2 recombinants

Live "attenuated" influenza virus vaccine protects animals against respiratory infections, including SARS-CoV-2

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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