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Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) breast cancer, according to results from a study at ESMO 2020.

21 Sep 2020

Researchers assess similarity of couples in pathophysiological mechanisms of type 2 diabetes

New research being presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD), held online this year, shows that when one half of a couple shows high levels of certain behaviours that prevent type 2 diabetes, such as good diet or exercise, that behaviour also tends to be high in the other half of the couple.

21 Sep 2020

COVAM assay may help select convalescent plasma units for treatment of acute COVID-19

A recent study published on the preprint server bioRxiv* seeks to establish the pattern of antibody reactivity in COVID-19 convalescent plasma (CCP), which is widely being used as a therapy for seriously ill COVID-19 patients.

21 Sep 2020

In vitro testing suggests effective novel drug combinations for SARS-CoV-2

A recent study published on the preprint server bioRxiv* in September 2020 shows the value of drug combinations to enhance the therapeutic and preventive efficacy of such repositioned drugs in standard antiviral therapy.

20 Sep 2020

Chinese workers knowledge, attitudes and practices regarding COVID-19

In new research, scientists in China have looked at the knowledge, attitudes, and practices regarding COVID-19 among Chinese workers. The research paper titled, “Knowledge, attitudes, and practices related to Coronavirus disease 2019 during the outbreak among workers in China: A large cross-sectional study,” is published in the latest issue of the journal PLOS Neglected Tropical Diseases.

20 Sep 2020

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

A team of researchers from Aix-Marseille Univ, IHU-Méditerranée Infection, Institut Paoli Calmettes and Laboratoire d’Immunologie, Marseille, France, conducted experiments to determine if SARS-CoV-2 can affect the myeloid compartment or infect monocytes and macrophages.

20 Sep 2020

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Using mouse models, scientists have investigated the active plasma metabolite of remdesivir, GS-441 524, and hydroxychloroquine as possible drug candidates in COVID-19. The research shows GS-441 524 could be an effective therapeutic drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while at the same time discounting hydroxychloroquine as a reliable anti-viral.

20 Sep 2020

Lopinavir-ritonavir does not suppress SARS-CoV-2 activity in vitro

Among them is the combination of lopinavir and ritonavir, which have been in use in an attempt to reduce the severity of the disease. However, a new South Korean study published on the preprint server bioRxiv in September 2020 shows that this combination is ineffective against the virus.

20 Sep 2020

Study identifies new regions of positive selection in SARS-CoV-2

Based on structural modeling of ribonucleic acid (RNA) and proteins, the researchers from Duke University argue that newly identified regions of positive selection in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely affect species-specific RNA instead of protein function – improving our understanding of the molecular mechanisms responsible for highly unique biological properties of this virus.

20 Sep 2020

Researchers try and pop SARS-CoV-2 with an AFM tip - virion surprisingly resilient

Researchers at Semmelweis University and the National Public Health Center in Hungary have conducted an imaging study showing that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for coronavirus disease 2019 (COVID-19), is a highly dynamic and resilient virus

20 Sep 2020

Large mother-child paired study promises more answers on COVID-19 in pregnancy

A new paper published in the preprint server medRxiv* in August 2020 reports the design and preliminary findings of an ongoing study on pregnant mothers and their children born during the pandemic.

20 Sep 2020

Novel sequencing method could be useful for COVID-19 research

Researchers at the University of Chicago and the Cleveland Clinic have presented a novel single-cell RNA sequencing method that could be a useful application for research into the current coronavirus disease 2019 (COVID-19) pandemic.

20 Sep 2020

Evidence-based approaches improve employment outcomes after spinal cord injury

Researchers at Kessler Foundation authored a new article, "Employment after spinal cord injury," (DOI: 10.1007/s40141-020-00266-4), published by Current Physical Medicine and Rehabilitation Reports on May 24, 2020.

19 Sep 2020

New polygenic risk score to help predict the odds of drugs causing liver damage

The ancient Romans studied the livers of sacrificial animals to read omens and make prophesies. Now researchers at Tokyo Medical and Dental University and Takeda-CiRA program along with a world-wide team of collaborators, have devised a polygenic risk score (PRS) based on liver genomics that can predict the likelihood of medications causing liver damage.

19 Sep 2020

U.S. adults experienced increased mental health issues as COVID-19 cases skyrocketed

U.S. adults increasingly experienced symptoms associated with acute stress and depression as COVID-19 cases and deaths skyrocketed between mid-March and mid-April 2020, according to a study of more than 6,500 people from three large, nationally representative cohorts.

19 Sep 2020

New method isolates antibody-like proteins that capture and neutralize SARS-CoV-2

Scientists have used a new high-speed, in vitro selection method to isolate 9 antibody-like proteins (ALPs) that bind to the SARS-CoV-2 virus - 4 of which also exhibited neutralizing activity - within 4 days, according to a new study.

19 Sep 2020

Research identifies new alteration in the brain of people with Alzheimer's

Despite the important advances in research in recent years, the etiopathogenesis of Alzheimer's disease is still not fully clarified. One of the key questions is to decipher why the production of beta amyloid, the protein that produces the toxic effect and triggers the pathology, increases in the brain of people with Alzheimer's.

19 Sep 2020

UB researchers aim to connect the dots on food access

Researchers know from many previous studies what prevents cash-strapped shoppers in underserved communities from buying more fresh produce.

19 Sep 2020

Access to low or no-cost meals disrupted due to school closures during COVID-19

School closures due to the COVID-19 pandemic disrupted access to low or no-cost school breakfast and lunch programs for millions of low-income children.

19 Sep 2020

Rising stress and depressive symptoms linked to pandemic-related losses, media consumption

Experiencing multiple stressors triggered by the COVID-19 pandemic – such as unemployment – and COVID-19-related media consumption are directly linked to rising acute stress and depressive symptoms across the U.S., according to a groundbreaking University of California, Irvine study.

19 Sep 2020

Medical Research News

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Researchers assess similarity of couples in pathophysiological mechanisms of type 2 diabetes

COVAM assay may help select convalescent plasma units for treatment of acute COVID-19

In vitro testing suggests effective novel drug combinations for SARS-CoV-2

Chinese workers knowledge, attitudes and practices regarding COVID-19

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Lopinavir-ritonavir does not suppress SARS-CoV-2 activity in vitro

Study identifies new regions of positive selection in SARS-CoV-2

Researchers try and pop SARS-CoV-2 with an AFM tip - virion surprisingly resilient

Large mother-child paired study promises more answers on COVID-19 in pregnancy

Novel sequencing method could be useful for COVID-19 research

Evidence-based approaches improve employment outcomes after spinal cord injury

New polygenic risk score to help predict the odds of drugs causing liver damage

U.S. adults experienced increased mental health issues as COVID-19 cases skyrocketed

New method isolates antibody-like proteins that capture and neutralize SARS-CoV-2

Research identifies new alteration in the brain of people with Alzheimer's

UB researchers aim to connect the dots on food access

Access to low or no-cost meals disrupted due to school closures during COVID-19

Rising stress and depressive symptoms linked to pandemic-related losses, media consumption

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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