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Study provides groundwork for restoring nerve-muscle connection in ALS

Patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, lose muscle control as nerve cells or neurons in the brain and spinal cord degenerate and can no longer send signals to muscles.

28 May 2020

Ferritin heavy chain protein shows promise as a potential SARS-CoV-2 vaccine or antiviral

A new study published on the online preprint server bioRxiv in May 2020 reports the construction and testing of a new ferritin-based antigen-bearing protein that has biological activity towards the ACE2 receptor. This could indicate its potential for development as a vaccine or antiviral.

28 May 2020

$Study finds increase in pediatric fractures sustained at home during COVID-19 pandemic$

Study finds increase in pediatric fractures sustained at home during COVID-19 pandemic

COVID-19 social distancing measures, including the closure of schools and parks and the indefinite cancellation of team sports, have led to a nearly 60% decrease overall in pediatric fractures but an increase in the proportion of fractures sustained at home, according to a new study by researchers at Children's Hospital of Philadelphia.

28 May 2020

Study finds gender differences in autism severity changes during early childhood

During early childhood, girls with autism tend to show greater reduction and less rise in their autism symptom severity than boys with autism, a UC Davis MIND Institute study has found.

28 May 2020

Pitt researcher to explore the neurological sex-based divide in dementia

Fifty million people worldwide are living with dementia, a broad term for diseases and conditions characterized by progressive cognitive decline.

28 May 2020

A closer look at TMPRSS2: This could help treat COVID-19

The transmembrane protease serine-type 2 (TMPRSS2) protein plays a key role in COVID-19 infection since it primes the viral spike protein to allow viral entry into the target cell. A new study by researchers at Imperial College London and published on the preprint server bioRxiv in May 2020 describes the protein, which could be an attractive drug target to help manage COVID-19.

28 May 2020

Inhibiting tumor signals can suppress the spread of cancer

For most people who die of cancer, the spread of the initial tumor is to blame. "Metastasis is what kills most cancer patients," says Serge Fuchs, a professor in Penn's School of Veterinary Medicine.

28 May 2020

CBD treatment improves arthritis symptoms in dogs, study finds

A team led by researchers at Baylor College of Medicine in collaboration with Medterra CBD conducted the first scientific studies to assess the potential therapeutic effects of cannabidiol for arthritic pain in dogs, and the results could lead the way to studying its effect in humans.

28 May 2020

Research provides important insights into genetic adaptation of SARS-CoV-2 to humans

In their groundbreaking paper available on the preprint server medRxiv, University of Pittsburgh researchers were appraising signals of SARS-CoV-2 genome evolution and found that purifying selection (i.e., removal of deleterious mutations) represents the dominant trait during early coronavirus disease (COVID-19) pandemic - suggesting that the virus will evolve as it diversifies in a growing number of hosts.

28 May 2020

New drug combinations could help overcome genetic immunotherapy resistance

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

28 May 2020

Researchers study the effect of major life events on wellbeing

Major life events such as marriage, death of a loved one or bankruptcy all affect our wellbeing. Now, for the first time, researchers have compared the differing impact of these events on the happiness and life satisfaction and how long that impact lasts.

28 May 2020

Adequate building ventilation can help tackle airborne transmission of Covid-19

Preventing airborne transmission of Covid-19 should be the next front of the battle against the virus, argue experts from the University of Surrey.

28 May 2020

Scientists create adenovirus that kills cancer cells

An adenovirus is now better able to target and kill cancer cells due to the addition of an RNA stabilizing element.

28 May 2020

Women and minorities inadequately represented in clinical trials for novel cardiometabolic drugs

Women and minorities, particularly African Americans, continue to be inadequately represented in clinical trials for novel cardiometabolic medications, with no evidence of improvement in enrollment numbers over the past decade, according to new research published last week in the Journal of the American Heart Association, an open-access journal of the American Heart Association.

28 May 2020

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic.

28 May 2020

Physical activity prevents the accumulation of damaged proteins and keeps muscles healthy

Researchers at the University of Copenhagen's Department of Nutrition, Exercise and Sports have demonstrated that physical activity prompts a clean-up of muscles as the protein Ubiquitin tags onto worn-out proteins, causing them to be degraded.

28 May 2020

Type 2 diabetes is more prevalent in American Indians and Alaska Natives

Type 2 diabetes (T2D) affects American Indians and Alaska Natives at approximately three times the rate of white Americans and is closely linked to the disproportionately high rates of cardiovascular diseases such as heart attacks and strokes, according to the American Heart Association Scientific Statement "Cardiovascular Health in American Indians and Alaska Natives," published today in the Association's flagship journal Circulation.

28 May 2020