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Celiac disease more common among Americans with Punjabi ancestry, study shows

About 1.8 million Americans have celiac disease, an immune-based condition brought on by the consumption of gluten in genetically susceptible patients. Among patients diagnosed with celiac disease by small intestinal biopsy in the U.S., those from the Punjab region of India have the highest rates of disease, according to new research published in Clinical Gastroenterology and Hepatology,1 the official clinical practice journal of the American Gastroenterological Association.

10 May 2016

Potential new intraocular treatment based on RAS manipulation can prevent or reverse diabetic retinopathy

Pathologic changes of the retina caused by diabetes is the leading cause of blindness in working adults. Diabetic retinopathy has no known cure, treatment options are inadequate, and prevention strategies offer limited protection. In the first of its kind, a report in The American Journal of Pathology describes a potential new intraocular treatment based on manipulating the renin angiotensin system (RAS) that both prevents and reverses some characteristics of diabetic retinopathy in a mouse model.

10 May 2016

Sophisticated technology helps model and simulate optimal dose for pediatric ependymoma patients

St. Jude Children's Research Hospital scientists have used sophisticated pharmacologic modeling and simulation to translate preclinical findings into a successful phase I clinical trial of a chemotherapy agent for treatment of ependymoma. The research marked the first time the approach has been used to calculate drug doses for a clinical trial in pediatric brain tumor patients.

10 May 2016

Researchers identify new psychological disorder, maladaptive maydreaming

A new psychological disorder has been identified in a series of recently published studies - Maladaptive Maydreaming (MD). Researchers from the University of Haifa, in Israel, Fordham University in New York City and University of Lausanne, Switzerland, have found that people with the disorder spend an average of 60% of their waking time in an imaginary world which they themselves have created, realizing that it is a fantasy, and without losing contact with the real world.

10 May 2016

Increasing ghrelin levels during hunger can negatively affect decision making capabilities

Never make a decision when you are hungry. The hormone ghrelin - that is released before meals and known to increase appetite - has a negative effect on both decision making and impulse control. Such were the results of a recently conducted study at Sahlgrenska University.

10 May 2016

Profiling gamma-retrovirus integration sites may help identify genes linked to specific cancer types

Identifying the sites where gamma-retroviruses commonly insert into the genome may help to identify genes associated with specific cancer types, according to a study published April 20, 2016 in the open-access journal PLOS ONE by Kathryn Gilroy at the University of Glasgow, UK, and colleagues.

10 May 2016

Scientists discover new genetic information about development of breast cancer

SCIENTISTS have unearthed crucial new genetic information about how breast cancer develops and the genetic changes which can be linked to survival, according to a Cancer Research UK-funded study published in Nature Communications today (Tuesday).

10 May 2016

Yellow fever outbreak: Researchers emphasize need to prepare for global health emergency

Evidence is mounting that the current outbreak of yellow fever is becoming the latest global health emergency, say two Georgetown University professors, who call on the World Health Organization to convene an emergency committee under the International Health Regulations. In addition, with frequent emerging epidemics, they call for the creation of a "standing emergency committee" to be prepared for future health emergencies.

10 May 2016

UCLA neurologist highlights steps that can help Americans reduce stroke risk

Getting more exercise, giving up cigarettes and monitoring cholesterol and blood pressure are a few steps Americans can take to reduce their risk of stroke, says Doojin Kim, MD, a neurologist at UCLA Medical Center, Santa Monica who often treats patients who have suffered a stroke, the No. 4 cause of death and the No. 1 cause of adult disability in the U.S.

10 May 2016

Researchers examine role of neural circuit in making decisions

Choosing what shirt to buy, what to order for lunch or whether to go with the hearty red wine or the lighter white all involve assigning values to the options. A small brain structure plays a central role in the many decisions like this we make each day. But it hasn't been clear how a limited number of neurons in this small part of the brain can support an unlimited number of choices.

10 May 2016

Scientists identify role of non-coding elements in shaping human-specific traits

Human-specific variants of four microRNAs may have altered expression levels and gene targets compared to other great apes, according to a study published April 22, 2016 in the open-access journal PLOS ONE by Alicia Gallego from the Institute of Evolutionary Biology, Spain, and colleagues.

10 May 2016

Study shows risk of developing MDD depends on symptom centrality in network

A novel study published in the current issue of Psychotherapy and Psychosomatics discloses how depression may develop.

10 May 2016

Trauma-focused cognitive behavioral therapy effective in overcoming PTSS in children, adolescents

A multicenter randomized controlled trial performed in Germany and published in the current issue of Psychotherapy and Psychosomatics discloses new indications for overcoming trauma in children and adolescents.

10 May 2016

Study highlights role of specific chromosomal deletion in cancer development, progression

In a typical cancer cell, up to one-quarter of the genome is lost due to large chromosomal deletions, while the concomitant loss of hundreds of genes creates vulnerabilities that are impossible to reveal through the study of individual genes. Prof. Anna Sablina and her team at VIB/KU Leuven optimized a workflow for the generation of cell lines with targeted chromosomal deletions.

10 May 2016

lncRNA in placenta may help protect unborn baby from invading pathogens

The human placenta is an organ unlike any other. During the course of nine months it is formed by the embryo, sustains life and then is shed.

10 May 2016

Mindfulness-based cognitive therapy more beneficial without antidepressant drugs

An investigation published in the current issue of Psychotherapy and Psychosomatics indicates that mindfulness based cognitive therapy (MBCT) is most helpful when antidepressant drugs are not used.

10 May 2016

Pathogen-selective approach to antibiotic development less disruptive to gut microbiome

St. Jude Children's Research Hospital scientists report the first evidence that a pathogen-specific antibiotic was less disruptive to the gut microbiome than broad-spectrum antibiotics.

10 May 2016

Study links lower concentration of heat-shock proteins to recurrence of thymic tumors

In most cases, tumors of the thymus gland are removed by surgical resection. However, they recur after a few years in up to one third of patients. A research team headed up by thoracic surgeon Bernhard Moser of the Thoracic Surgery Department at MedUni Vienna has successfully demonstrated that these tumors form heat-shock proteins. The lower the concentration of these proteins, the more quickly tumors recur. The study has been published in the leading journal Scientific Reports.

10 May 2016

Novel iPad simulation app can instruct future nurses in monitoring babies and mothers during labor

Sheila Taylor leaned in to see the baby's heartbeat rhythm. She watched as the baby's heartbeat line fell without a corresponding spike showing the mother's uterus contracting down on it.

10 May 2016

New research on epigenetics of lactose intolerance unravels understanding of schizophrenia

A new study on the epigenetics of lactose intolerance may provide an approach to understanding schizophrenia and other complex, serious illnesses

10 May 2016

Medical Research News

Celiac disease more common among Americans with Punjabi ancestry, study shows

Potential new intraocular treatment based on RAS manipulation can prevent or reverse diabetic retinopathy

Sophisticated technology helps model and simulate optimal dose for pediatric ependymoma patients

Researchers identify new psychological disorder, maladaptive maydreaming

Increasing ghrelin levels during hunger can negatively affect decision making capabilities

Profiling gamma-retrovirus integration sites may help identify genes linked to specific cancer types

Scientists discover new genetic information about development of breast cancer

Yellow fever outbreak: Researchers emphasize need to prepare for global health emergency

UCLA neurologist highlights steps that can help Americans reduce stroke risk

Researchers examine role of neural circuit in making decisions

Scientists identify role of non-coding elements in shaping human-specific traits

Study shows risk of developing MDD depends on symptom centrality in network

Trauma-focused cognitive behavioral therapy effective in overcoming PTSS in children, adolescents

Study highlights role of specific chromosomal deletion in cancer development, progression

lncRNA in placenta may help protect unborn baby from invading pathogens

Mindfulness-based cognitive therapy more beneficial without antidepressant drugs

Pathogen-selective approach to antibiotic development less disruptive to gut microbiome

Study links lower concentration of heat-shock proteins to recurrence of thymic tumors

Novel iPad simulation app can instruct future nurses in monitoring babies and mothers during labor

New research on epigenetics of lactose intolerance unravels understanding of schizophrenia

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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