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SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

A new study indicates that low-level resistance of SARS-CoV-2 to remdesivir is not widespread and dissimilar to other RNA viruses revealing evolutionary predictability of this pandemic virus.

22 Sep 2021

Evidence for safety of Pfizer-BioNTech’s COVID-19 vaccine booster dose

Researchers have conducted a study demonstrating the safety of administering a third (booster) dose of Pfizer-BioNTech’s BNT162b2 vaccine.

22 Sep 2021

SARS-CoV-2 delta variant has higher viral RNA levels and increased infectivity, suggests study

The study found that the delta and epsilon variants exhibited significantly higher infectivity than alpha, with delta containing approximately six times as much infectious virus for the same amount of RNA.

22 Sep 2021

New framework needed to explore links between evolved pathogen tolerance and emerging infections

A new multidisciplinary research framework is needed to explore links between evolved tolerance to pathogens and their spillover into humans, scientists write today in the journal eLife.

22 Sep 2021

Research highlights potentially life-saving screening for HR-HPV–driven head and neck cancers

Cancer causing high-risk human papillomaviruses (HR-HPV) are responsible for the rising incidence of HR-HPV–driven head and neck cancers (HNC), particularly oropharyngeal cancers (OPC, or throat cancers). Investigators have determined that HR-HPV DNA can be detected in saliva in most patients with HPV-driven OPC at the time of diagnosis. This work highlights a potentially life-saving screening program based on salivary HR-HPV DNA testing for early cancer detection and patient monitoring. Their findings appear in The Journal of Molecular Diagnostics, published by Elsevier.

22 Sep 2021

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

22 Sep 2021

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online in Cancer Research, a journal of the American Association for Cancer Research, and point to a new therapeutic opportunity for this type of ovarian cancer for which new solutions are urgently needed.

22 Sep 2021

Researchers explore which types of brain activity support consciousness

Consciousness remains one of the brain's biggest mysteries. We know very little about how it emerges from activity within the brain, but most neuroscientists agree consciousness is dynamic in nature.

22 Sep 2021

High-fat diet or genetically induced obesity can lead to loss of hair follicles

It's well known that obesity is linked to the development of numerous diseases in humans. Heart disease, diabetes, and other ailments are extremely common in obese individuals.

21 Sep 2021

Comparison of recombinant SARS-CoV-2 receptor binding domain produced in mammalian, insect, and bacterial cells

In a recent study, RBD produced in various cell types are characterized in-depth, comparing their applicability for future COVID-19 research.

21 Sep 2021

Discovery points toward a new strategy for treating Parkinson’s disease

University of Utah Health scientists have identified a molecule that slows cells’ production of alpha-synuclein, a protein that forms toxic aggregates in the brains of people with Parkinson’s disease.

21 Sep 2021

Nasal drugs show success in slowing Parkinson's disease progression in mice

Potential new treatments for Parkinson's disease developed by researchers at Rush University Medical Center have shown success in slowing progression of the disease in mice.

21 Sep 2021

Researchers create a living bioengineered nerve circuit to tackle opioid overdose crisis

In 2019, nearly 50,000 people in the United States died from opioid overdoses, bringing the total of number of deaths from the opioid crisis to half a million over the past 10 years, according to the U.S. Centers for Disease Control.

21 Sep 2021

KU researcher wins $1.25 million award to investigate the vital role of sex hormones in tissue repair

Our ability to heal and regenerate new tissue after an injury has much to do with biological sex. For instance, following menopause, the loss of sex-hormone signaling in women can lead to degenerative diseases such as osteoporosis and osteoarthritis, where bone and cartilage degrade and become more delicate and brittle because of tissue loss.

21 Sep 2021

Scientists identify potential therapeutic targets to alleviate severe COVID-19 in aged patients

The scientists assessed epidemiological data from March to December 2020 from the CDC to investigate the prevalence of COVID-19 disease among different age groups.

21 Sep 2021

Three US COVID-19 vaccines provide substantial protection against hospitalization

A new study reports that a head-to-head comparison of the efficacy of the three vaccines used in the USA indicates substantial protection against hospitalization with COVID-19 following vaccination with any of these vaccines.

21 Sep 2021

Breath measurements can be used to determine antibiotic concentrations in the body

A team of engineers and biotechnologists at the University of Freiburg has for the first time shown in mammals that the concentration of antibiotics in the body can be determined using breath samples. The breath measurements also corresponded to the antibiotic concentrations in the blood.

21 Sep 2021

Medical Science News

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

Evidence for safety of Pfizer-BioNTech’s COVID-19 vaccine booster dose

SARS-CoV-2 delta variant has higher viral RNA levels and increased infectivity, suggests study

New framework needed to explore links between evolved pathogen tolerance and emerging infections

Research highlights potentially life-saving screening for HR-HPV–driven head and neck cancers

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Researchers explore which types of brain activity support consciousness

High-fat diet or genetically induced obesity can lead to loss of hair follicles

Comparison of recombinant SARS-CoV-2 receptor binding domain produced in mammalian, insect, and bacterial cells

Discovery points toward a new strategy for treating Parkinson’s disease

Nasal drugs show success in slowing Parkinson's disease progression in mice

Researchers create a living bioengineered nerve circuit to tackle opioid overdose crisis

KU researcher wins $1.25 million award to investigate the vital role of sex hormones in tissue repair

Scientists identify potential therapeutic targets to alleviate severe COVID-19 in aged patients

Three US COVID-19 vaccines provide substantial protection against hospitalization

Breath measurements can be used to determine antibiotic concentrations in the body

COVID-19 and the widening online information gap

Researchers pioneer simple but revolutionary approach to early Alzheimer's diagnosis

Physical activity may hasten plaque build-up in the coronary arteries, finds research

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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