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Immune evasion by SARS-CoV-2 facilitated by a mutational hotspot in the NTD

Researchers discuss mutations in the NTD of the spike protein, which contains an antigenic “supersite” and is the target for nAbs.

24 Oct 2021

Mapping the molecular gene signatures of respiratory viruses, including SARS-CoV-2

Researchers compare a large cohort of transcriptomic dataset maps of gene regulation by SARS-CoV-2 infection.

24 Oct 2021

Vaccination data from Puerto Rico strongly supports COVID19 booster shots

In a recent study, researchers from the U.S. examined the vaccine effectiveness against SARS-CoV-2 infections in Puerto Rico.

24 Oct 2021

Study findings may lead to new treatments to fight deadly C. difficile infections

A University of California, Irvine-led study suggests that the glucosyltransferase domain (GTD) is an ideal molecular target for therapeutic interventions for Clostridioides difficile infection (CDI). These findings may lead to new treatments to fight this deadly disease.

22 Oct 2021

Specific amino acid supplementation could prevent the development of dementia

Dementia- a condition involving the extreme loss of cognitive function- is caused by a variety of disorders, including Alzheimer's disease.

22 Oct 2021

Gene therapy strategy against Angelman syndrome shows early promise

Scientists at the UNC School of Medicine have reported in the journal JCI Insight encouraging early tests of a gene therapy strategy against Angelman syndrome, a neurodevelopmental disorder that features poor muscle control and balance, hard-to-treat epilepsy, and intellectual disabilities.

22 Oct 2021

Study reveals key role of fat cells in cognitive decline and neurodegeneration

Findings published this week reveal new insights into the role of fat cells in cognitive decline and neurodegeneration, according to a study that involves the oxidant amplification loop led by Marshall University scientists.

22 Oct 2021

Researchers identify mechanism behind insufficient treatment efficacy of psoriasis drugs

Interleukin-12 - a messenger molecule of immune cells - was long considered to trigger the development of psoriasis.

22 Oct 2021

Chemical substance may specifically inhibit both SARS-CoV-2 proteases and human protease

Researchers tested analogs of disulfiram on SARS-CoV-2 Mpro and PLpro to find more efficient and effective inhibitors that take advantage of disulfiram’s mechanism of binding to the cysteine residue.

22 Oct 2021

Mu and C.1.2 variant spike proteins partially resistant to neutralization by vaccine-elicited antibodies

A team of researchers measured the infectivity of SARS-CoV-2 variants C.1.2, Mu, and Delta+501S spike proteins and determined the susceptibility to neutralizing antibodies.

22 Oct 2021

SARS-CoV-2 anti-nucleocapsid antibodies reduce risk of reinfection for at least eight months

A new study concludes that at least with predominantly wild-type variants, the risk of reinfection with the virus among unvaccinated people is reduced by 80% or more.

22 Oct 2021

Study shows immune profile heterogeneity amongst healthy adults

Researchers opted to use single-cell RNA-seq to observe single cells in detail as they encounter a specific antigen.

22 Oct 2021

Using saliva to predict COVID-19 severity in children

News-Medical speaks to Dr. Usha Sethuraman about her research into COVID-19 and how saliva could be used to help predict COVID-19 severity in children.

22 Oct 2021

Health and climate change in Australia

The 2021 MJA–Lancet Countdown report represents a collaborative effort between University College London, and seven Australian institutions, mediated by The Lancet in partnership with The Medical Journal of Australia.

22 Oct 2021

Immunogenicity and efficacy of adjuvanted SARS-CoV-2 beta variant subunit booster in rhesus macaques

Scientists studied the efficacy of an intranasal booster composed of beta variant-spike protein S1 with IL-15 and TLR agonists in macaques that were previously immunized.

22 Oct 2021

Replication of SARS-CoV-2 variants in different cell and organ models

In this study, the replication of B.1.1.7 viruses was analyzed in different cell and organ models and dwarf hamsters.

22 Oct 2021

Development of a safe and effective COVID-19 nanoparticle vaccine

Researchers from ReVacc scientific have attempted to demonstrate the effectiveness of a new vaccine, REVC-128, two weeks post-administration.

22 Oct 2021

Hydrogel-based vaccine delivery system evokes antibody response against SARS-CoV-2

Researchers from Stanford University have been attempting to create a hydrogel-based vaccine delivery system that could improve the immune response's strength and duration.

22 Oct 2021

Study maps neurons essential for social behavior and healthy relationships within groups

Meaningful social interactions are critical to an individual's well-being, and such interactions rely on people's behaviors towards one another.

22 Oct 2021

Boosting nonhuman primates with Moderna vaccine increases neutralizing antibody responses

Boosting nonhuman primates with the Moderna vaccine (mRNA-1273) six months after their primary vaccine series increased neutralizing activity against viral variants of concern, a new study shows.

22 Oct 2021

Medical Science News

Immune evasion by SARS-CoV-2 facilitated by a mutational hotspot in the NTD

Mapping the molecular gene signatures of respiratory viruses, including SARS-CoV-2

Vaccination data from Puerto Rico strongly supports COVID19 booster shots

Study findings may lead to new treatments to fight deadly C. difficile infections

Specific amino acid supplementation could prevent the development of dementia

Gene therapy strategy against Angelman syndrome shows early promise

Study reveals key role of fat cells in cognitive decline and neurodegeneration

Researchers identify mechanism behind insufficient treatment efficacy of psoriasis drugs

Chemical substance may specifically inhibit both SARS-CoV-2 proteases and human protease

Mu and C.1.2 variant spike proteins partially resistant to neutralization by vaccine-elicited antibodies

SARS-CoV-2 anti-nucleocapsid antibodies reduce risk of reinfection for at least eight months

Study shows immune profile heterogeneity amongst healthy adults

Using saliva to predict COVID-19 severity in children

Health and climate change in Australia

Immunogenicity and efficacy of adjuvanted SARS-CoV-2 beta variant subunit booster in rhesus macaques

Replication of SARS-CoV-2 variants in different cell and organ models

Development of a safe and effective COVID-19 nanoparticle vaccine

Hydrogel-based vaccine delivery system evokes antibody response against SARS-CoV-2

Study maps neurons essential for social behavior and healthy relationships within groups

Boosting nonhuman primates with Moderna vaccine increases neutralizing antibody responses

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

Data management challenges in scientific research

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