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Lymphangiogenesis predicts favorable outcomes to immunotherapy

Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy.

8 Jun 2021

New technology can explain the effect of genetic factors on brain structure, function

Liang Zhan, assistant professor of electrical and computer engineering at Pitt's Swanson School of Engineering, received a $500,000 CAREER award from the National Science Foundation to develop computational tools that improve our understanding of the human brain.

8 Jun 2021

New method successfully reversed male infertility in mice

The ability of stem cells to fix impaired functions of host tissues after transplantation has been a lifesaving breakthrough in treating previously incurable conditions. Much like a coin toss, however, the fate of the transplanted stem cells is unpredictable. They may choose self-renewal, grow into a different kind of tissue, or die.

8 Jun 2021

Study confirms the importance of low-protein, high-carbohydrate diet

Researchers at the University of Sydney's Charles Perkins Centre conducted the largest ever study of nutrient interactions by examining the health of mice on 33 different diets containing various combinations of protein to carbs, and different sources of carbohydrate.

8 Jun 2021

New generative model has wide implications in developmental biology, regenerative medicine

Various forms of complex multicellular organisms have evolved on Earth, ranging from simple Volvox carterii which possess only 2 cell- types to us humans with more than 200 cell types. All originate from a single celled zygote, and their developmental processes depend on switch-like gene regulation.

8 Jun 2021

Study reveals mechanisms by which SGLT2 inhibitors produce renoprotective effect

SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli.

8 Jun 2021

Brain-computer interfacing can predict a person's attraction to a not-yet-seen face

A research team from the University of Copenhagen and University of Helsinki demonstrates it is possible to predict individual preferences based on how a person's brain responses match up to others. This could potentially be used to provide individually-tailored media content -- and perhaps even to enlighten us about ourselves.

8 Jun 2021

Study examines how SARS CoV-2 aerosols travel through the lower lungs

When we inhale isolated coronavirus particles, more than 65% reach the deepest region of our lungs where damage to cells can lead to low blood oxygen levels, new research has discovered, and more of these aerosols reach the right lung than the left.

8 Jun 2021

Scientists explain why space travel weakens the human immune system

Microgravity in space perturbs human physiology and is detrimental for astronaut health, a fact first realized during early Apollo missions when astronauts experienced inner ear disturbances, heart arrhythmia, low blood pressure, dehydration, and loss of calcium from their bones after their mission.

8 Jun 2021

Researchers develop promising stem cell therapy to treat type 1 diabetes

Type 1 diabetes, which arises when the pancreas doesn't create enough insulin to control levels of glucose in the blood, is a disease that currently has no cure and is difficult for most patients to manage.

8 Jun 2021

Data from pre-adolescent brain activation study may clarify risk factors for mental health disorders

Youth brain activation data from the largest longitudinal neuroimaging study to date provides valuable new information on the cognitive processes and brain systems that underlie adolescent development and might contribute to mental and physical health challenges in adulthood.

8 Jun 2021

New research identifies protein as therapeutic anti-viral target for COVID-19

New research identified a novel interaction between the SARS-CoV-2 spike protein and the galectin-3-binding protein (LGALS3BP) which could be a new therapeutic anti-viral target.

7 Jun 2021

Measuring how patterns of gene expression change in children may help predict T1D progression

Type 1 diabetes (T1D) is an autoimmune disease in which a misdirected immune system gradually destroys healthy pancreatic islet β cells, resulting in a lack of insulin.

7 Jun 2021

COVID-19 can cause long-term consequences for the kidneys

The kidneys are a target organ of COVID-19 and are affected very early in the course. However, this is precisely where there is strong prognostic potential: As early as last spring, COVID-19-associated nephritis was identified as an early warning signal for severe courses of the infectious disease and studies to that effect were published.

7 Jun 2021

New book explores minimally invasive techniques and technology for sports medicine

A new book edited by Chad D. Lavender, M.D., an assistant professor of orthopedic surgery at the Marshall University Joan C. Edwards School of Medicine, explores novel minimally invasive techniques and technology for treating sports medicine and orthopedic injuries.

7 Jun 2021

Restoring gut microbes can improve antibiotic-induced dysbiosis and prevent colitis in mice

A new study at the University of Chicago has determined that restoring a single microbial species -- Bacteroides sp. CL1-UC (Bc) -- to the gut microbiome at a key developmental timepoint can prevent antibiotic-induced colitis in a mouse model of the condition.

7 Jun 2021

Experimental monoclonal antibody could be a new weapon against HIV epidemic

An experimental, lab-made antibody can completely prevent nonhuman primates from being infected with the monkey form of HIV, new research published in Nature Communications shows.

7 Jun 2021

Discovery offers a potential new pathway to treat hypertension

High blood pressure, or hypertension, is the leading modifiable risk factor for cardiovascular diseases and premature death worldwide.

7 Jun 2021

Potential leptin therapy for nonalcoholic steatohepatitis

In those with fatty liver disease, a person's fat goes to their liver instead of their fat tissue, either because of an absence of fat depots, which is seen in the rare genetic disease lipodystrophy, or because the depots are too full, which is seen in people with obesity.

7 Jun 2021

Gene therapy may be a safe and effective single-dose treatment for soft bone disease

A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10--a gene therapy that replaces a key enzyme found in bone--may be a safe and effective single-dose treatment for hypophosphatasia (HPP).

7 Jun 2021

Medical Science News

Lymphangiogenesis predicts favorable outcomes to immunotherapy

New technology can explain the effect of genetic factors on brain structure, function

New method successfully reversed male infertility in mice

Study confirms the importance of low-protein, high-carbohydrate diet

New generative model has wide implications in developmental biology, regenerative medicine

Study reveals mechanisms by which SGLT2 inhibitors produce renoprotective effect

Brain-computer interfacing can predict a person's attraction to a not-yet-seen face

Study examines how SARS CoV-2 aerosols travel through the lower lungs

Scientists explain why space travel weakens the human immune system

Researchers develop promising stem cell therapy to treat type 1 diabetes

Data from pre-adolescent brain activation study may clarify risk factors for mental health disorders

New research identifies protein as therapeutic anti-viral target for COVID-19

Measuring how patterns of gene expression change in children may help predict T1D progression

COVID-19 can cause long-term consequences for the kidneys

New book explores minimally invasive techniques and technology for sports medicine

Restoring gut microbes can improve antibiotic-induced dysbiosis and prevent colitis in mice

Experimental monoclonal antibody could be a new weapon against HIV epidemic

Discovery offers a potential new pathway to treat hypertension

Potential leptin therapy for nonalcoholic steatohepatitis

Gene therapy may be a safe and effective single-dose treatment for soft bone disease

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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