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Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

Researchers from the US tested the prophylactic potential of a combination of 2 mAbs administered 3 or 75 days before respiratory challenge in rhesus macaques. They used the rhesus macaque model to test the added benefit of combinatory parenteral administration of 2 high-affinity anti-SARS-CoV-2 mAbs - C144-LS and C135-LS. These mAbs were developed to neutralize the virus and tweaked to improve their pharmacokinetics.

1 Jun 2021

New discovery in Ewing sarcoma may prevent tumor metastasis from occurring

A new discovery in Ewing sarcoma, an aggressive and often fatal childhood cancer, has uncovered the potential to prevent cancer cells from spreading beyond their primary tumor site.

1 Jun 2021

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

A team of researchers from the US and Belgium applied a structure-based approach with early monitoring of cathepsin L inhibition along with SARS-CoV-2 3CLpro inhibition. They identified a potent and selective SARS-CoV-2 3CLpro inhibitor, ALG-097111, which has proven activity against SARS-CoV-2 in SARS-CoV-2 hamster models in vivo. This study is published in the journal, Biochemical and Biophysical Research Communications.

1 Jun 2021

Study offers longitudinal roadmap of immune activation and resolution in mild COVID-19

Researchers from the US recently profiled the longitudinal immune response in mild COVID-19 patients starting with early time points of 1-15 days post-infection through convalescence to over 100 days after onset of symptoms.

1 Jun 2021

Overweight or obesity amplifies harmful effects of alcohol on the liver

Led by the University of Sydney's Charles Perkins Centre, the study looked at medical data from nearly half a million people and found having overweight or obesity considerably amplified the harmful effects of alcohol on liver disease and mortality.

1 Jun 2021

Adolescents with higher levels of omega-3 fatty acids less likely to develop psychotic disorder

New research has found that adolescents with higher levels of an omega-3 fatty acid in their blood were less likely to develop psychotic disorder in early adulthood, suggesting that it may have a potential preventative effect of reducing the risk of psychosis.

1 Jun 2021

Study reveals a novel neuronal code for spatial perception

The brain is often likened to a computer: its hardware - neurons organized in complex circuits, its software - a plethora of codes that govern the neurons' behavior.

1 Jun 2021

Weaker association between brain activity and cerebrospinal fluid flow increases the likelihood of Alzheimer's disease

New imaging research shows that brain activity during sleep was less connected with cerebrospinal fluid flow in patients with Alzheimer's disease.

1 Jun 2021

Researchers identify common epitopes across SARS-CoV-2 viral variants

While several COVID-19 vaccine candidates have been developed and deployed to arrest the spread of SARS-CoV-2, concern among scientists and public health authorities is mounting over the immunity escape potential of emerging viral variants. To address this problem, a group of scientists in Germany has undertaken research to identify molecular targets across viral variants to aid in the development of second and third-generation vaccines and novel therapeutics.

1 Jun 2021

How the decline in fish biodiversity is affecting human nutrition

Researchers have found that biomass compensation may impair the health of populations that depend on fish for their daily nutritional intake.

1 Jun 2021

Can depression increase the likelihood of rapid kidney function decline?

In a recent study, the presence of depressive symptoms in normally healthy individuals was found to correlate with rapid kidney function decline.

1 Jun 2021

Overconfidence in judgment increases the susceptibility to believing misinformation

New findings demonstrate that the likelihood of falling victim to false news increases with the belief they can distinguish false from real news.

1 Jun 2021

Vitamin D may be ineffective in protecting against COVID-19

A study published in PLOS Medicine suggests that genetic evidence does not support vitamin D as a protective measure against COVID-19.

1 Jun 2021

New material can enable a near-perfect merger between machines and the human body

Researchers at DTU Health Tech have developed a new material that can facilitate a near-perfect merger between machines and the human body for diagnostics and treatment.

31 May 2021

Tai chi mirrors the beneficial effects of conventional exercise, study shows

A new study shows that tai chi mirrors the beneficial effects of conventional exercise by reducing waist circumference in middle-aged and older adults with central obesity. The study was done by investigators at the University of Hong Kong, The Chinese University of Hong Kong; Chinese Academy of Sciences; and UCLA.

31 May 2021

Cognitive reappraisal may reduce compulsive drug-seeking behavior in cocaine-addicted individuals

An emotion regulation strategy known as cognitive reappraisal helped reduce the typically heightened and habitual attention to drug-related cues and contexts in cocaine-addicted individuals, a study by Mount Sinai researchers has found.

31 May 2021

Researchers repurpose pre-existing anti-SARS-CoV antibody to develop potent neutralizing antibody against SARS-CoV-2

A team of scientists from the United States has recently engineered a pre-existing anti-severe acute respiratory syndrome coronavirus (SARS-CoV) neutralizing antibody to increase its binding affinity for the spike receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The engineered antibody demonstrates high potency in neutralizing SARS-CoV-2 and preventing infection in animals.

31 May 2021

Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?

An interesting new study by researchers at the University of Portsmouth, UK, describes the use of a mathematical method to sequence genomes based on information theory. The method offers an alternative to clinical techniques, allowing mutations to be detected and possibly even predicted. In this way, it opens new research opportunities in bioinformatics and genetics.

31 May 2021

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

SARS-CoV-2 has a single-stranded RNA genome encoding both structural and non-structural proteins. Of these, the latter is known to play a variety of roles in viral replication and the assembly of new viral particles, as well as in suppressing cellular immune responses. A new study reports the activity of one such protein, the non-structural protein 14 (NSP14), which activates the inflammatory mediator NF-κB to trigger intense inflammation.

31 May 2021

Inflammatory brain injury higher in men with acute COVID-19, finds study

The COVID-19 pandemic has been associated with both short- and long-term neurologic complications, including stroke, brain fog and persistent tiredness. A new study concludes that the effects of SARS-CoV-2 on the central nervous system (CNS) are due to the endothelial injury and inflammation that this produces in the brain.

31 May 2021

Medical Science News

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

New discovery in Ewing sarcoma may prevent tumor metastasis from occurring

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

Study offers longitudinal roadmap of immune activation and resolution in mild COVID-19

Overweight or obesity amplifies harmful effects of alcohol on the liver

Adolescents with higher levels of omega-3 fatty acids less likely to develop psychotic disorder

Study reveals a novel neuronal code for spatial perception

Weaker association between brain activity and cerebrospinal fluid flow increases the likelihood of Alzheimer's disease

Researchers identify common epitopes across SARS-CoV-2 viral variants

How the decline in fish biodiversity is affecting human nutrition

Can depression increase the likelihood of rapid kidney function decline?

Overconfidence in judgment increases the susceptibility to believing misinformation

Vitamin D may be ineffective in protecting against COVID-19

New material can enable a near-perfect merger between machines and the human body

Tai chi mirrors the beneficial effects of conventional exercise, study shows

Cognitive reappraisal may reduce compulsive drug-seeking behavior in cocaine-addicted individuals

Researchers repurpose pre-existing anti-SARS-CoV antibody to develop potent neutralizing antibody against SARS-CoV-2

Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

Inflammatory brain injury higher in men with acute COVID-19, finds study

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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