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Skeletal muscle activity regulates circadian rhythm of the liver

The biological clock/circadian rhythm is the mechanism that ensures that a certain physiological process takes place at a specific time of the day or night.

23 Sep 2021

Researchers use new laser-assisted technology for bioprinting adult neuron cells

A group of researchers including a Concordia PhD student have developed a new method of bioprinting adult neuron cells. They're using a new laser-assisted technology that maintains high levels of cell viability and functionality.

22 Sep 2021

Serum modified PTEN levels associated with increased risk of kidney function decline

High levels of a polyubiquinated form of phosphatase and tensin homolog (PTEN) were associated with an almost four-fold higher risk of a 40% decline in kidney function in a cohort of American Indians with or at high risk of diabetic kidney disease.

22 Sep 2021

MMRI explores overlapping cardiac conditions as result of electrocution

It's not uncommon for people to live normal, healthy lives without knowledge of any underlying genetic conditions. However, all it takes is one external impact, such as a heart attack, to induce the expression of the condition.

22 Sep 2021

Penn Medicine and Wistar secure $11.7 million SPORE grant for three melanoma research projects

Penn Medicine and The Wistar Institute have been awarded a prestigious $11.7 million Specialized Programs of Research Excellence, or SPORE, grant from the National Cancer Institute.

22 Sep 2021

mRNA-based and adenoviral vector-based COVID-19 vaccines elicit diverse humoral immunity

Scientists from the USA have recently compared the dynamics of humoral and cellular immune responses induced by mRNA-based and adenoviral vector-based coronavirus disease 2019 (COVID-19) vaccines. The findings reveal a difference in humoral immune responses. The study is currently available on the medRxiv* preprint server.

22 Sep 2021

The importance of handwashing in the COVID-19 era: Back to basics

Researchers from the United States have reviewed the different components of formulated soaps and their performance as cleansers and pathogen inactivators, the criticality of the time spent hand washing, the relationships between water temperature and pathogen inactivation.

22 Sep 2021

Pinning down Pin1: Potential COVID-19 therapy

In a recent study scientists have demonstrated that Pin1 is one of the key cellular molecules necessary for SARS-CoV-2 propagation.

22 Sep 2021

The role of nanomaterials during the COVID-19 pandemic

A new review published in Rare Metals has focused on the applications of nanomaterials to fight the ongoing COVID-19 pandemic.

22 Sep 2021

Hypertonic saline solution shown to inhibit replication of SARS-CoV-2

Researchers at the University of São Paulo (USP) in Brazil have shown that a hypertonic saline solution inhibits replication of SARS-CoV-2, the virus that causes COVID-19, and have elucidated the biochemical mechanism involved.

22 Sep 2021

COVID-19 vaccination in IBD patients

In this review, researchers reviewed all published research related to Phase 1/2 and/or Phase 3 and 4 studies of SARS-CoV-2 vaccinations.

22 Sep 2021

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

A new study indicates that low-level resistance of SARS-CoV-2 to remdesivir is not widespread and dissimilar to other RNA viruses revealing evolutionary predictability of this pandemic virus.

22 Sep 2021

Evidence for safety of Pfizer-BioNTech’s COVID-19 vaccine booster dose

Researchers have conducted a study demonstrating the safety of administering a third (booster) dose of Pfizer-BioNTech’s BNT162b2 vaccine.

22 Sep 2021

SARS-CoV-2 delta variant has higher viral RNA levels and increased infectivity, suggests study

The study found that the delta and epsilon variants exhibited significantly higher infectivity than alpha, with delta containing approximately six times as much infectious virus for the same amount of RNA.

22 Sep 2021

New framework needed to explore links between evolved pathogen tolerance and emerging infections

A new multidisciplinary research framework is needed to explore links between evolved tolerance to pathogens and their spillover into humans, scientists write today in the journal eLife.

22 Sep 2021

Research highlights potentially life-saving screening for HR-HPV–driven head and neck cancers

Cancer causing high-risk human papillomaviruses (HR-HPV) are responsible for the rising incidence of HR-HPV–driven head and neck cancers (HNC), particularly oropharyngeal cancers (OPC, or throat cancers). Investigators have determined that HR-HPV DNA can be detected in saliva in most patients with HPV-driven OPC at the time of diagnosis. This work highlights a potentially life-saving screening program based on salivary HR-HPV DNA testing for early cancer detection and patient monitoring. Their findings appear in The Journal of Molecular Diagnostics, published by Elsevier.

22 Sep 2021

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

22 Sep 2021

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online in Cancer Research, a journal of the American Association for Cancer Research, and point to a new therapeutic opportunity for this type of ovarian cancer for which new solutions are urgently needed.

22 Sep 2021

Researchers explore which types of brain activity support consciousness

Consciousness remains one of the brain's biggest mysteries. We know very little about how it emerges from activity within the brain, but most neuroscientists agree consciousness is dynamic in nature.

22 Sep 2021

High-fat diet or genetically induced obesity can lead to loss of hair follicles

It's well known that obesity is linked to the development of numerous diseases in humans. Heart disease, diabetes, and other ailments are extremely common in obese individuals.

21 Sep 2021

Medical Science News

Skeletal muscle activity regulates circadian rhythm of the liver

Researchers use new laser-assisted technology for bioprinting adult neuron cells

Serum modified PTEN levels associated with increased risk of kidney function decline

MMRI explores overlapping cardiac conditions as result of electrocution

Penn Medicine and Wistar secure $11.7 million SPORE grant for three melanoma research projects

mRNA-based and adenoviral vector-based COVID-19 vaccines elicit diverse humoral immunity

The importance of handwashing in the COVID-19 era: Back to basics

Pinning down Pin1: Potential COVID-19 therapy

The role of nanomaterials during the COVID-19 pandemic

Hypertonic saline solution shown to inhibit replication of SARS-CoV-2

COVID-19 vaccination in IBD patients

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

Evidence for safety of Pfizer-BioNTech’s COVID-19 vaccine booster dose

SARS-CoV-2 delta variant has higher viral RNA levels and increased infectivity, suggests study

New framework needed to explore links between evolved pathogen tolerance and emerging infections

Research highlights potentially life-saving screening for HR-HPV–driven head and neck cancers

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Researchers explore which types of brain activity support consciousness

High-fat diet or genetically induced obesity can lead to loss of hair follicles

Advancing Motor Neuron Disease Diagnosis with Non-Invasive Ultrasound and AI

How agentic AI is reshaping laboratory workflows

Fourier 80: bringing benchtop NMR systems to the laboratory

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