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Study reveals new mutations that make cancer resistant to KRAS-targeted therapies

A gene called KRAS is one of the most commonly mutated genes in all human cancers, and targeted drugs that inhibit the protein expressed by mutated KRAS have shown promising results in clinical trials, with potential approvals by the U.S. Food and Drug Administration anticipated later this year.

7 Apr 2021

Study shows how leptin suppresses appetite

Since the discovery of leptin in the 1990s, researchers have wondered, how does leptin, a hormone made by body fat, suppress appetite? Despite tremendous gains in the intervening three decades, many questions still remain.

7 Apr 2021

Researchers discover two new ways to treat small cell lung tumors

Using samples of small cell lung tumors, a research team led by biologist Dr Silvia von Karstedt has discovered two new ways to induce tumor cell death. One of two subsets of tumor cells can be targeted by activating ferroptosis: iron-dependent cell death caused by oxidative stress

7 Apr 2021

Researchers determine key protein structure that may lead to effective treatments for schizophrenia

Glycine is the smallest amino acid - one of the building blocks of proteins. It acts also as a neurotransmitter in the brain, enabling neurons to communicate with each other and modulating neuronal activity.

7 Apr 2021

Rice University, Houston Methodist launch collaboration to solve clinical problems with neurorobotics

Neurosurgery's history of cutting diseases out of the brain is morphing into a future in which implanting technology into the brain may help restore function, movement, cognition and memory after patients suffer strokes, spinal cord injuries and other neurological disorders.

6 Apr 2021

'Brain glue' may aid in functional neural repair after severe TBI

At a cost of $38 billion a year, an estimated 5.3 million people are living with a permanent disability related to traumatic brain injury in the United States today, according to the Centers for Disease Control and Prevention.

6 Apr 2021

$10.8 million grant from NIH helps establish Arkansas Integrative Metabolic Research Center

A $10.8 million grant from the National Institutes of Health will enable an interdisciplinary team of researchers at the University of Arkansas and University of Arkansas for Medical Sciences to address the role of cell and tissue metabolism in rare and common diseases such as cancer, diabetes, obesity and mitochondrial disorders.

6 Apr 2021

Chemical substances in some cosmetic and beauty products could increase risk of endometriosis

Researchers from the University of Granada and the "San Cecilio de Granada" Teaching Hospital confirm that endocrine disruptors—chemical substances that may mimic or block the action of hormones—are present in some cosmetic products

6 Apr 2021

Study discovers how microcephaly and blindness may develop in Zika-infected fetuses

A study led by Edward Wojcik, PhD, Associate Professor of Biochemistry & Molecular Biology at LSU Health New Orleans School of Medicine, identified how microcephaly (abnormally small heads) and blindness may develop in Zika-infected fetuses, as well as a new way to potentially prevent these neurodevelopmental defects.

6 Apr 2021

Natural selection and adaptation of SARS-CoV-2 in mammals

Researchers of the Hubei University of Medicine, China, have analyzed several mutations in different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from mammal species that suggest natural selection and host adaptation are occurring in the virus.

6 Apr 2021

Mother's stress levels during conception could be a determinant of fetal sex

A study carried out by scientists from the University of Granada has revealed that women who experience stress both before becoming pregnant and during conception are almost twice as likely to have a girl as a boy.

6 Apr 2021

Researchers identify a novel SARS-CoV-2 variant (A.VOI.V2) in southern Africa

Scientists recently explored the transmission dynamics of currently circulating variants of SARS-CoV-2 in a southern African country. By analyzing the genomic sequences of these variants, they have identified a novel SARS-CoV-2 variant with multiple spike mutations. They have temporarily designated the variant A.VOI.V2.

6 Apr 2021

Implantable sensor based on gold nanoparticles revolutionizes medical diagnostics

The idea of implantable sensors that continuously transmit information on vital values and concentrations of substances or drugs in the body has fascinated physicians and scientists for a long time. Such sensors enable the constant monitoring of disease progression and therapeutic success.

6 Apr 2021

Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

Researchers from Northwestern University and the University of Rochester in the U.S. addressed this question in their study. The researchers also explored whether the vaccines administered across the world could confer sterilizing immunity while preventing severe disease and death.

6 Apr 2021

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

To date, little evidence has been documented regarding the immune responses after the onset of the symptoms or virus detection. Further, no cross-sectional studies have been conducted that define the time of infection. Thereby, no report is available that explains the relationship between the earliest immune responses to COVID-19 and temporal kinetics. New research deals with this research gap using blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing methods.

6 Apr 2021

Study suggests T-cells don't determine survival in severe COVID-19

In the study, which appeared on the pre-print server medRxiv, the team found that when the monkeys were reinfected, the T cell-depleted animals showed anamnestic immune responses, the enhanced reaction of the body's immune system to an antigen that is related to an antigen previously encountered.

6 Apr 2021

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options.

6 Apr 2021

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

In a methodologically ‘state-of-the-art’ approach, US researchers have developed a protein-based nanoparticle vaccine against coronavirus disease (COVID-19), with a swift generation of antibodies and the potential to protect individuals who cannot receive other COVID-19 vaccines for medical reasons. The research is posted to the bioRxiv* preprint server.

5 Apr 2021

Devastating liver disease itching turns out to have a surprising cause

A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation.

5 Apr 2021

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure

Like a bad water pump that fails to circulate coolant in a car engine, a failing heart struggles to pump blood through the body, causing symptoms of fatigue, shortness of breath, and swelling in the legs and feet.

5 Apr 2021

Medical Science News

Study reveals new mutations that make cancer resistant to KRAS-targeted therapies

Study shows how leptin suppresses appetite

Researchers discover two new ways to treat small cell lung tumors

Researchers determine key protein structure that may lead to effective treatments for schizophrenia

Rice University, Houston Methodist launch collaboration to solve clinical problems with neurorobotics

'Brain glue' may aid in functional neural repair after severe TBI

$10.8 million grant from NIH helps establish Arkansas Integrative Metabolic Research Center

Chemical substances in some cosmetic and beauty products could increase risk of endometriosis

Study discovers how microcephaly and blindness may develop in Zika-infected fetuses

Natural selection and adaptation of SARS-CoV-2 in mammals

Mother's stress levels during conception could be a determinant of fetal sex

Researchers identify a novel SARS-CoV-2 variant (A.VOI.V2) in southern Africa

Implantable sensor based on gold nanoparticles revolutionizes medical diagnostics

Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

Study suggests T-cells don't determine survival in severe COVID-19

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

Devastating liver disease itching turns out to have a surprising cause

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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