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Brain stimulation highlights ancestral brain highway system shared by humans and monkeys

Scientists have identified that the evolutionary development of human and primate brains may have been similar for communication and memory.

25 Jan 2021

Missing surface protein allows small cell lung cancer cells to hide from immune defenses

Small cell lung cancer (SCLC) cells are missing a surface protein that triggers an immune response, allowing them to hide from one of the body's key cancer defenses, a new study led by UT Southwestern researchers suggests.

25 Jan 2021

COVID-19 diagnostic tests remain able to detect all published virus strains

Paris, France and Camberley, UK – 21 December 2020 – Novacyt (EURONEXT GROWTH: ALNOV; AIM: NCYT), an international specialist in clinical diagnostics, announces that following the detection of a new variant of COVID-19 by the UK’s COVID19 Genomics UK consortium, known as VUI-202012/01, the Company has carried out a detailed analysis of the mutations in this new variant and in all published COVID-19 strains to fully assess the reliability of its existing diagnostic tests.

From AFSBio 25 Jan 2021

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

The cover for issue 2 of Oncotarget features Figure 4, "Combination therapy TA99/ICB reduced the lung tumor burden in the B16 model of metastases," published in "Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma" by Pérez-Lorenzo, et al. which reported that here, the authors showed that removing immune suppression and enhancing stimulatory signals increased the anti-tumor activity of unmodified TA99 antibodies with a significant reduction of growth of solid tumors and lung metastases in mouse models of melanoma.

25 Jan 2021

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

The cover for issue 52 of Oncotarget features Figure 1, "Volcano plots of DNA methylation in tumor tissues compared with nontumor tissue," published in "Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma" by Morine, et al. which reported that the authors conducted a genome-wide analysis of DNA methylation of the tumor and non-tumor tissue of 15 patients with Hepatocellular carcinoma (HCC), and revealed TBX15 was the most hypermethylated gene of the tumor.

25 Jan 2021

New maintenance treatment for AML shows strong benefit for patients

Patients with acute myeloid leukemia (AML), the most common form of acute leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance treatment, according to a randomized, international phase 3 clinical trial for which Weill Cornell Medicine and NewYork-Presbyterian are trial sites.

22 Jan 2021

Researchers identify protein that may represent a safer treatment target for pancreatic cancer

Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer.

22 Jan 2021

Treating 'fetus as the patient' could reduce the incidence of pre-term labor and premature birth

The results of a study by researchers at the University of Texas Medical Branch may pave the way for a new medicine delivery system that could reduce the incidence of pre-term labor and premature birth by allowing physicians to treat the 'fetus as the patient'.

22 Jan 2021

UC researchers test new combination therapy for head and neck cancer in animal models

Head and neck cancer is the sixth most common cancer worldwide, and while effective treatments exist, sadly, the cancer often returns.

22 Jan 2021

Lack of sleep, stress, mental health problems can lead to PCS-like symptoms

A new study suggests that a lot of people might be going through life with symptoms that resemble concussion - a finding supporting researchers' argument that athletes recovering from a brain injury should be assessed and treated on a highly individualized basis.

22 Jan 2021

Combination therapy shows potential for treating lung cancer

Most lung cancers are of a type called non-small-cell lung carcinoma (NSCLC). This type of cancer is relatively insensitive to chemotherapy, so NSCLC therapies are usually based on drug treatment.

22 Jan 2021

Digital twin approach for cardiology opens up new possibilities in clinical diagnostics

Using mathematical image processing, scientists at the BioTechMed-Graz research cooperation have found a way to create digital twins from human hearts. The method opens up completely new possibilities in clinical diagnostics.

22 Jan 2021

Novel neutralizing antibodies targeting SARS-CoV-2 N-terminal domain discovered

A new study by US-based researchers shows the presence of protective antibodies that target the N-terminal domain (NTD) of the spike instead of the spike receptor-binding domain (RBD).

22 Jan 2021

Researchers discover direct link between placental function and future metabolic disorders

Researchers at the University of Colorado Anschutz Medical Campus have discovered a direct association between placental function in pregnant women and future metabolic disorders in children and adults, a finding that could lead to earlier intervention and diagnosis of disease.

22 Jan 2021

Can the onset and end of an epidemic be predicted? A SARS-CoV-2 modeling case study

A recent study by researchers in France shows how differences in infection history and viral spread patterns are important factors in predicting the time course of a localized epidemic of SARS-CoV-2.

22 Jan 2021

New model explains controversies over saturated fats and heart disease risk

In science, sometimes a new perspective can turn our interpretation of the data upside-down, and necessitate a paradigm shift.

22 Jan 2021

How have new SARS-CoV-2 strains become more transmissible?

A new study discusses the effect of specific mutations on the sensitivity of SARS-CoV-2's spike protein to elastase, and on the intramolecular conformational changes.

22 Jan 2021

Researchers update automated computation tool for SARS-CoV-2 genome analysis

Researchers updated a previous version of an automated tool to include SARS-CoV-2 genome analysis. Genome analysis using the freely available software could help track the evolution of the virus and promptly identify variants that increase viral transmission or virulence.

22 Jan 2021

SARS-CoV-2’s nonstructural proteins dysregulate immune responses, study finds

Researchers provide an overview of SARS-CoV-2 and its life cycle pathways, addressing the functional changes in the viral proteins, providing important strategic clues to help that may help in the ongoing development of therapies against COVID-19.

22 Jan 2021

Does hypertension always lead to severe COVID-19?

Researchers have developed some prognostic factors to predict the severity of COVID-19 among hypertensive patients.

22 Jan 2021

Medical Science News

Brain stimulation highlights ancestral brain highway system shared by humans and monkeys

Missing surface protein allows small cell lung cancer cells to hide from immune defenses

COVID-19 diagnostic tests remain able to detect all published virus strains

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

New maintenance treatment for AML shows strong benefit for patients

Researchers identify protein that may represent a safer treatment target for pancreatic cancer

Treating 'fetus as the patient' could reduce the incidence of pre-term labor and premature birth

UC researchers test new combination therapy for head and neck cancer in animal models

Lack of sleep, stress, mental health problems can lead to PCS-like symptoms

Combination therapy shows potential for treating lung cancer

Digital twin approach for cardiology opens up new possibilities in clinical diagnostics

Novel neutralizing antibodies targeting SARS-CoV-2 N-terminal domain discovered

Researchers discover direct link between placental function and future metabolic disorders

Can the onset and end of an epidemic be predicted? A SARS-CoV-2 modeling case study

New model explains controversies over saturated fats and heart disease risk

How have new SARS-CoV-2 strains become more transmissible?

Researchers update automated computation tool for SARS-CoV-2 genome analysis

SARS-CoV-2’s nonstructural proteins dysregulate immune responses, study finds

Does hypertension always lead to severe COVID-19?

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

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