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Study identifies a novel regulatory pathway in bladder cancer

Researchers from Johns Hopkins University in collaboration with Insilico Medicine announce the publication of a new research paper titled "GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma" in Science Signaling.

20 Aug 2020

New kirigami-based shoe sole could help mitigate the risks of slips and falls

Losing your balance and falling does not just happen during icy Boston winters. The slip resistance of your shoes can determine how well you walk on different surfaces without losing balance.

20 Aug 2020

Post-mortem study of dead COVID-19 patients finds lung damage and blood clots

A new post-mortem study of patients who have died from COVID-19 found severe damage to the lungs and signs of blood clotting in major organs.

20 Aug 2020

A metabolic enzyme shows great potential as target for immunotherapies

The metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system.

20 Aug 2020

Sortilin may hold the key to developing more effective treatment for pancreatic cancer

Pancreatic cancer has an extremely poor prognosis; it is the third most common cause of cancer deaths in the United States.

20 Aug 2020

New surgical technique could lead to better dialysis outcomes

A new technique developed by a Yale-led research team improves blood flow in surgically made blood vessels used in dialysis, enables them to last longer, and results in fewer complications than the standard technique.

20 Aug 2020

Study may lead to novel therapies for asthma

Researchers identify master regulator genes of asthma, provide new path forward in the study of asthma and the development of novel therapies.

20 Aug 2020

Scientists investigate the role of contractility and microbiota in chronic constipation

Chronic constipation (CC) remains a serious medical and social problem because the complexity of diagnosis, the lack of a single approach to treatment, and unsatisfactory treatment results.

20 Aug 2020

Study reveals a promising treatment for Parkinson's disease

Scientists at the University Bath in the UK have discovered a series of protein structures that are thought to be highly relevant to the onset of Parkinson's disease.

20 Aug 2020

Cells lining the nose are key entry point for coronavirus, shows study

Scientists at Johns Hopkins Medicine, experimenting with a small number of human cell samples, report that the "hook" of cells used by SARS-CoV-2 to latch onto and infect cells is up to 700 times more prevalent in the olfactory supporting cells lining the inside of the upper part of the nose than in the lining cells of the rest of the nose and windpipe that leads to the lungs.

20 Aug 2020

Study shows why certain genetically predisposed individuals do not develop heart disease

Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can lead to elevated cholesterol and increased risk for a premature heart attack.

20 Aug 2020

Inhibition of key receptor implicated in post-stroke damage and recovery

Many people who suffer a stroke are permanently disabled. Stroke remains the leading cause of long-term disability in the United States.

20 Aug 2020

Study may lead to new targeted therapies that inhibit the spread of cancer

For decades, physicians have known that many kinds of cancer cells often spread first to lymph nodes before traveling to distant organs through the bloodstream.

20 Aug 2020

Study indicates a potential link between Alzheimer's and common brain disorder

Alzheimer's disease is one of the most common causes of dementia, and while most people might know someone who is affected by it, the genetic factors behind the disease are less known.

20 Aug 2020

Study shows Klotho supplementation can prevent hypertension

High blood pressure is often called a silent killer because it is the biggest risk factor for the most death and disability worldwide including heart disease and stroke, but presents no symptoms as a warning indicator.

20 Aug 2020

Researchers identify mechanism that explains lower-quality immune response in COVID-19 patients

The release of massive amounts of proteins called cytokines can lead to some of the most severe symptoms of COVID-19.

20 Aug 2020

Cytokine storms may prevent the development of long-term immunity to SARS-CoV-2

Shiv Pillai, MD, PhD, investigator in the Ragon Institute of MGH, MIT and Harvard and professor at Harvard Medical School (HMS), recently published a paper in Cell showing that that high levels of some cytokines seen in COVID-19 patients, as part of a cytokine storm, may prevent the development of long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

19 Aug 2020

New database could speed the development of gene-targeted therapies for breast cancer

All current breast cancer drugs were first tested in cell lines. Each cell line began as cancer in a patient. As such, each cell line is a surrogate for that patient's disease.

19 Aug 2020

Researchers elucidate mechanisms underlying spatial memory impairment in Alzheimer's

Alzheimer's disease is one of the most serious diseases in an aging society, yet the cause is often unclear and there is no appropriate treatment method.

19 Aug 2020

New approach to chronic pain treatment could bring relief

Something like a quarter of the world's population suffers from chronic pain at some point in their lives. As opposed to acute pain - for example, the feeling after hitting your finger with a hammer - chronic pain may not even have a clear cause, and it can linger for years or lifetimes.

19 Aug 2020